Navigation Links
New agent inhibits HCV replication in mouse models -- No resistance seen
Date:5/30/2013

Treatments against hepatitis C virus have only been partially successful. A major problem is that antivirals generate drug resistance. Now Seong-Wook Lee of Dankook University, Yongin, Republic of Korea and his collaborators have developed agents that bind to the business end of a critical protein, disabling it so successfully that no resistance has arisen. The research is published in the June 2013 issue of the Journal of Virology.

The target protein for the new agents is the NS5B replicase protein, which is the central catalytic enzyme in HCV replication. The researchers developed "RNA aptamers" which bind tightly to the part of that protein that performs the catalysis, disabling the replicase. Aptamers are short nucleic acids or peptides that provide the same level of recognition and binding ability that is common to antibodies.

The aptamers inhibited HCV replication without generating escape mutants, says Lee. Moreover, the aptamers inhibited diverse genotypes of HCV, neither causing toxicity nor inducing innate immunity, he says. Lee notes that in the study, therapeutic quantities of ligand-conjugated aptamer penetrated the liver tissue in the mice, raising the likelihood that therapeutically effective quantities could ultimately be achieved in HCV patients.

Roughly 170 million people worldwide are infected with HCV, says Lee, and it is the major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. There is as yet "no efficient and specific single regimen against HCV," says Lee. Current treatments are associated with many side effects, partly because rapid generation of drug-resistant virus has forced clinicians to use combinations of several drugs, resulting in greater numbers of side effects in patients than if a single agent could be used. And even with the drug combinations only some patients can generate a sustained antiviral response.


'/>"/>

Contact: James Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Bacterial security agents go rogue
2. Pitt team finds immunity protein that ramps up inflammation, and agents that can block it
3. Molecular Imaging Agents: Targets, Technology, Markets, and Commercial Opportunities
4. Hydrogen sulfide: The next anti-aging agent?
5. Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes
6. Lady beetle diet influences its effectiveness as biocontrol agent
7. Preventive detention for oxidizing agents
8. Developing second skin military fabric to repel chemical and biological agents
9. Production of FRP components without release agents
10. Novel non-antibiotic agents against MRSA and common strep infections
11. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
(Date:5/14/2015)... May 14, 2015  Verificient Technologies, Inc., ... and online remote proctoring, announced a new ... company and creator of the Canvas Learning ... two companies will benefit from the seamless ... As a fully integrated multifactor biometrics ...
(Date:5/11/2015)... Ohio , May 11, 2015  Through a well-rounded ... Ohio had a strong showing at AUVSI,s Unmanned ... These representatives of Ohio,s UAS industry ... and abroad from all points along the UAS ecosystem. ... Development Coalition,s (DDC) Vice President for Aerospace Rich Knoll ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... Fla. If worms could talk, they might tell ... with that telltale come slither look. But worms send ... chemical code researchers are now cracking, according to a ... Nature . Scientists from the University of ...
... fire is currently burning through a study area where projections ... used data and analysis from the Gotchen Late-Successional Reserve (LSR) ... where the Cold Springs fire is now active. The Gotchen ... in Washington, and covers about 15,000 acres of the Mount ...
... a domestic renewable fuel source could generate enough electricity ... America,s entire consumption needs and lead to a significant ... research published today, Thursday, 24 July, in the Institute ... journal paper, ,Cow Power: The Energy and Emissions Benefits ...
Cached Biology News:Mate or hibernate? That's the question worm pheromones answer 2Mate or hibernate? That's the question worm pheromones answer 3Landscape study may offer solutions for fire managers 2Cow power could generate electricity for millions 2
(Date:6/2/2015)... today celebrated the North American launch of an innovative ... the size of a city block in New York ... the public, and special appearances by industry leaders and ... best total engine protection by addressing three prominent causes ... "With the launch of Shell V-Power NiTRO+ ...
(Date:6/2/2015)... MIAMI (PRWEB) June 02, 2015 Global ... Latin America distributor for Bioquark, Inc.’s biologic products for the ... is the latest in Global Stem Cells Group’s ambitious expansion ... region’s growing demand for access to regenerative medicine and stem ... on the development of biologics that have the ability to ...
(Date:6/2/2015)... YORK , Jun. 02, 2015 Tauriga ... a diversified life sciences company with interests in ... proprietary synthetic biology platform technology, today announced that ... Typenex Co-Investment, LLC ("Typenex") in exchange for a ... 16, 2015, the Company and Typenex entered into ...
(Date:6/2/2015)... , June 02, 2015 Research and ... Jain PharmaBiotech,s new report "Biomarkers - Technologies, ... This report follows the broad definition of ... objectively measured and evaluated as an indicator of ... pharmacological responses to a therapeutic intervention. Tests based ...
Breaking Biology Technology:New Shell V-Power NiTRO+ Premium Gasoline Introduces Breakthrough Formulation for BEST TOTAL Engine Protection 2New Shell V-Power NiTRO+ Premium Gasoline Introduces Breakthrough Formulation for BEST TOTAL Engine Protection 3New Shell V-Power NiTRO+ Premium Gasoline Introduces Breakthrough Formulation for BEST TOTAL Engine Protection 4Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 2Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 3Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 2Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 3Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 4Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 2Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 3
... , THOUSAND OAKS, Calif., Sept. 14 Amgen (Nasdaq: ... Merrill Lynch Global Healthcare Conference on Thursday, Sept. 17, 2009, in ... will present at the conference. Live audio of the presentation will ... Web site, www.amgen.com, under Investors. , , ...
... , BOTHELL, Wash., Sept. ... a leading developer, manufacturer, and marketer of biopreservation tools ... will distribute the Company,s proprietary HypoThermosol and CryoStor biopreservation ... agreement. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20090814/BIOLIFELOGO ...
... SUNNYVALE, Calif., Sept. 14 Pharmacyclics, Inc. (Nasdaq: ... commercializing innovative small molecule drugs for the treatment of immune ... financial results for the fourth quarter and fiscal year ended ... September 17, 2009 at 1:30 p.m. PDT (4:30 p.m. EDT). ...
Cached Biology Technology:BioLife Solutions Announces HypoThermosol(R) and CryoStor(TM) Distribution Agreement With Sigma-Aldrich 2BioLife Solutions Announces HypoThermosol(R) and CryoStor(TM) Distribution Agreement With Sigma-Aldrich 3Pharmacyclics Announces Date of Fourth Quarter and Fiscal Year End 2009 Conference Call 2
... This CLS number is a ... match Cornings product number. If showing ... the old Sigma-Aldrich number (Z71,517-4) or ... Material: cap polystyrene (expanded surface, easy ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Material: ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,704-5) ... assistance. ...
... The pYD1 Yeast Display Vector is ... proteins on the surface of Saccharomyces cerevisiae. ... ability to interact with known or putative ... receptor which consists of two domains, Aga1 ...
Biology Products: