Navigation Links
New agent inhibits HCV replication in mouse models -- No resistance seen
Date:5/30/2013

Treatments against hepatitis C virus have only been partially successful. A major problem is that antivirals generate drug resistance. Now Seong-Wook Lee of Dankook University, Yongin, Republic of Korea and his collaborators have developed agents that bind to the business end of a critical protein, disabling it so successfully that no resistance has arisen. The research is published in the June 2013 issue of the Journal of Virology.

The target protein for the new agents is the NS5B replicase protein, which is the central catalytic enzyme in HCV replication. The researchers developed "RNA aptamers" which bind tightly to the part of that protein that performs the catalysis, disabling the replicase. Aptamers are short nucleic acids or peptides that provide the same level of recognition and binding ability that is common to antibodies.

The aptamers inhibited HCV replication without generating escape mutants, says Lee. Moreover, the aptamers inhibited diverse genotypes of HCV, neither causing toxicity nor inducing innate immunity, he says. Lee notes that in the study, therapeutic quantities of ligand-conjugated aptamer penetrated the liver tissue in the mice, raising the likelihood that therapeutically effective quantities could ultimately be achieved in HCV patients.

Roughly 170 million people worldwide are infected with HCV, says Lee, and it is the major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. There is as yet "no efficient and specific single regimen against HCV," says Lee. Current treatments are associated with many side effects, partly because rapid generation of drug-resistant virus has forced clinicians to use combinations of several drugs, resulting in greater numbers of side effects in patients than if a single agent could be used. And even with the drug combinations only some patients can generate a sustained antiviral response.


'/>"/>

Contact: James Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Bacterial security agents go rogue
2. Pitt team finds immunity protein that ramps up inflammation, and agents that can block it
3. Molecular Imaging Agents: Targets, Technology, Markets, and Commercial Opportunities
4. Hydrogen sulfide: The next anti-aging agent?
5. Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes
6. Lady beetle diet influences its effectiveness as biocontrol agent
7. Preventive detention for oxidizing agents
8. Developing second skin military fabric to repel chemical and biological agents
9. Production of FRP components without release agents
10. Novel non-antibiotic agents against MRSA and common strep infections
11. Project MICREAgents: Self-assembling smart microscopic reagents to pioneer pourable electronics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... sulfur-oxidizing bacterial group called SUP05 will play an increasingly ... world,s oceans as oxygen minimum zones expand, according to ... the National Academy of Sciences . , University of ... anoxic fjord, Canada,s Saanich Inlet, to chart how microbial ... "Our study paints a very detailed picture of how ...
(Date:7/23/2014)... 2015, Springer will publish the International Journal of ... of the Taiwan Fuzzy Systems Association (TFSA). The cooperation ... in the area of fuzzy research., The International ... high-quality papers that deal with the theory, design and ... and extension theory systems ranging from hardware to software. ...
(Date:7/23/2014)... July 23, 2014   MedNet Solutions , ... clinical study management systems, is pleased to announce ... life sciences industry executive with over 25 years ... (COO).  Clareece will be responsible for MedNet,s day-to-day ... efficiency and quality product/service delivery.  ...
Breaking Biology News(10 mins):Research charts the ecological impact of microbial respiration in the oxygen-starved ocean 2MedNet Appoints Clareece West As Chief Operating Officer 2
... 21 researchers from 11 nations, including professor Robert "JJ" Orth ... first-ever study of the risk of extinction for individual seagrass ... the International Union for the Conservation of Nature (IUCN), shows ... at an elevated risk of extinction, while 3 species qualify ...
... who reported not taking a daily prenatal vitamin immediately before ... as likely to have a child with an autism spectrum ... the associated risk rose to seven times as great when ... at the UC Davis MIND Institute has found. "Mothers ...
... body against infection don,t huff and puff, but some ... against infection don,t huff and puff, but some of ... steam engine. Weizmann Institute scientists have discovered a mechanism ... when the inflammatory mechanism that protects cells against viruses ...
Cached Biology News:New study provides global analysis of seagrass extinction risk 2Women who start prenatal vitamins early are less likely to have children with autism 2Women who start prenatal vitamins early are less likely to have children with autism 3Women who start prenatal vitamins early are less likely to have children with autism 4Immune system release valve 2
(Date:7/22/2014)... (PR Web) July 21, 2014 (PRWEB) July 23, ... for Biomaterials, at Rutgers University. , The ... and ideas across the full spectrum of scientists ... selected research and development topics that represent the ... have been programmed to:,     Provide ...
(Date:7/22/2014)... lecturer in mechanical engineering at the University of Texas ... by the North Texas section of the American Society ... 130,000 members in 158 countries who develop engineering standards ... engineering community, benefiting the world. , ASME recognized Baughn ... Engineers honors banquet. Baughn retired as an engineering fellow ...
(Date:7/22/2014)... Rice Lake, Wisconsin (PRWEB) July 22, 2014 ... will be in attendance at the 2014 NCSL ... Florida. Booth #423 will feature CONDEC pressure ... balance style weights, and the new, customized sets, ... years ago to promote cooperative efforts in solving ...
(Date:7/22/2014)... og SHENZHEN , ... Solutions Co., LTD, (BGI Tech), et datterselskab af ... af en ny human whole exome-sekvenseringstjeneste baseret på ... Genomics, højt anset i branchen for at levere ... registrering af alle typer varianter, blev købt af ...
Breaking Biology Technology:The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2UT Dallas professor receives Engineer of the Year award 2Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2
... ... originating from abattoirs located in the US, Mexico, Canada, and Australia. ... dialysis, or gamma irradiation are available as standard catalog items. Spectrum ... research. Each FBS order includes a full biochemical and chemical profile, ...
... Pictures paint concepts of a thousand words- now, for the ... words paint concepts in our minds. The team, including ... the University of Leicester in the UK, Professor Itzhak Fried ... at the California Institute of Technology, has published these findings ...
... July 23 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals, Inc. (NASDAQ: ... short form base shelf prospectus with the securities commissions ... registration statement on Form S-3 with the United States ... Offering Documents, when made final and / or declared ...
Cached Biology Technology:Spectrum Announces Fetal Bovine Serum Product Line 2Oprah, Luke Skywalker and Maradona -- new study investigates how our brains respond to them 2Oprah, Luke Skywalker and Maradona -- new study investigates how our brains respond to them 3Angiotech Pharmaceuticals, Inc. announces filing of shelf-registration statement 2Angiotech Pharmaceuticals, Inc. announces filing of shelf-registration statement 3Angiotech Pharmaceuticals, Inc. announces filing of shelf-registration statement 4
Complete cell culture media with cytokines...
NPT1 (M-19)...
... vacuum cups provide flexible sealing lips ... irregular surfaces. ,PFG: Flat cup ,PBG: ... ,PCG: Multiple Bellows cup , ... to 200 mm , Multiple suction ...
8 different frozen tissues are mounted on positively charged glass slides...
Biology Products: