Navigation Links
New ability to regrow blood vessels holds promise for treatment of heart disease
Date:2/16/2012

p>

Doctors have typically treated ischemia by physically opening the closed artery with a stent or surgically rerouting blood flow to the poorly perfused tissue. Both methods have limitations, however, and are not effective long-term.

The new method introduced by Baker and his research team builds off of a promising revascularization approach that, up until now, has shown limited efficacy in clinical trials for treating human disease.

The method combines a growth factor a substance capable of stimulating cellular growth, proliferation and cellular differentiation, as well as healing wounds known as fibroblast growth factor 2 (FGF-2) with a lipid-embedded receptor to enhance its activity.

A challenge for scientists and engineers, however, has been getting FGF-2 to bind with cell receptors the very molecules often found on the surface of the cell that receive chemical signals and direct activity in the cell from outside sources.

To overcome this, Baker's method embeds the growth factors in synthetic lipid-based nanoparticles containing a coreceptor known as syndecan-4. The nanoparticles containing co-receptors that, when delivered with the growth factor, enable improved cell binding so that the growth factor can direct the targeted cell to divide, proliferate and form new cells for tissue regrowth.

The incased substance was injected into rats with hindlimb ischemia and stimulated a complete recovery from the ischemia in just seven days.

"We hope this research will increase our understanding of how tissues become resistant to revascularization therapies and may lead to more effective treatments for this widespread and debilitating disease," said Baker, who was recognized last year with the National Institutes of Health Director's New Innovator Award.

Designed to support unusually creative new investigators with highly innovative research ideas at an early stage of their career, the award provides Ba
'/>"/>

Contact: Melissa Mixon
melissa.mixon@austin.utexas.edu
512-471-2129
University of Texas at Austin
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study looks at possible link to hyper-excitability factors in epilepsy, autism and more
2. Sustainability, college athletics dont always connect
3. Diet, nutrient levels linked to cognitive ability, brain shrinkage
4. Slow road to stability for emulsions
5. Study of Yellowstone wolves improves ability to predict their responses to environmental changes
6. New materials capability to increase weapons explosive force demonstrated at Navy test range
7. NJIT professor plans 2012 sustainability workshop in Canada
8. Is sustainability science really a science?
9. After 25 years, sustainability is a growing science thats here to stay
10. Study details links between climate, groundwater availability - will help states prepare for drought
11. Bats show ability to change their ear shapes, making their hearing more flexible
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
(Date:12/24/2014)... in December 2014, the 1U™ app has helped ... remember their usernames and passwords through replacing the antiquated system ... people who have struggled to remember usernames and passwords, ... on redefining identity, announced today that it is offering the ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season ... as Acuity Market Intelligence reports that the long anticipated ... forecasts that intensifying demand for smart phones, tablets, and ... global market of 2.5 billion users with nearly 4.8 ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... step closer to finding new drugs to fight MRSA, ... organisation announced that its fungal collection will be screened ... of the world’s largest genetic resource collections of fungi, ... producing isolate. They will be supplying the University ...
... chimpanzees’ cognitive abilities, according to new research from the ... The study (1) is the first to demonstrate that ... cognitive abilities, as measured by their ability to understand ... published online in the Springer journal Animal Cognition. , ...
... garden armed with plants, consider who you place next to ... as passive as widely assumed, at least not with strangers. ... competitive when forced to share their pot with strangers of ... siblings. , The study appears today in the Royal ...
Cached Biology News:Could fungal collection hold the key to new life-saving drugs? 2Nurtured chimps rake it in 2Plants recognize their siblings, biologists discover 2
(Date:1/22/2015)... Boston, MA (PRWEB) January 22, 2015 ... systems, is pleased to announce an exciting product from a ... of motion analysis solutions over the past 15 years, with ... industries. Most recently, their 3D IMU system (inertial measurement unit), ...
(Date:1/22/2015)... Jersey , 22 de enero de 2015  El Dr. ... hoy su llamada a nominaciones para 2015. Este prestigioso ... hecho, o tiene el potencial para hacer, contribuciones destacadas ... se aceptarán hasta el 15 de marzo de 2015 ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 “Preparative ... Gas, HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, ... Food & Agriculture) - Forecasts to 2019” provides ... challenges, opportunities, current market trends, and strategies impacting ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
... UCB today announced that the U.S. Food,and Drug ... review, a,biologics license application (BLA) for Cimzia(R) (certolizumab ... rheumatoid arthritis (RA).,Cimzia(R) is an investigational agent. If ... anti-TNF (Tumor Necrosis Factor) biologic therapy,available for the ...
... Feb. 6 GeoPharma, Inc. (Nasdaq:,GORX) (the "Company") announced ... wide of an audience as possible it has placed ... on its website at, http://www.GeoPharmainc.com under the "Analyst ... will be speaking publicly several times in,the next few ...
... 6 Cepheid (Nasdaq:,CPHD) will announce financial results ... the markets close on Thursday, Feb. 28, 2008. ... call and webcast that afternoon at,4:30 p.m. Eastern ... Bishop, Chief Executive Officer, and Michael Myhre, Vice,President, ...
Cached Biology Technology:FDA Agrees to Review Cimzia(R) File for the Treatment of Rheumatoid Arthritis 2FDA Agrees to Review Cimzia(R) File for the Treatment of Rheumatoid Arthritis 3Recent Research Reports and Near-Term Corporate Events 2Recent Research Reports and Near-Term Corporate Events 3Cepheid Schedules Teleconference and Webcast for 2007 Fourth Quarter and Full Year Results 2
Volume adapter mounts on top of the 96 well FiltrEX filter plate and allows larger volumes (1mL) to be applied to each well in a filter plate. Adapters are nonsterile....
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
... developed to significantly increase the shelf life ... is increased at room temperature storage conditions ... product is subjected to 0.2 micron filtration, ... This formulation insures consistently high levels of ...
This unique buffer provides a gentle method for removal of primary and secondary antibodies to allow several reprobings on the same membrane. Gentle buffer will not alter the antigen for subsequent i...
Biology Products: