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New University of Colorado paper shows novel way to study human inflammatory disease
Date:2/25/2010

and neurological signs. In addition, specialized white blood cells known as hemophagocytic macrophages accumulated in the organs of the body, including bone marrow.

The team previously showed that salmonella-infected mice developed hemophagocytic macrophages, which ingest other white and red blood cells. "These earlier findings helped lead us down the current research path," said Detweiler.

"One part of this study is to try to use our research to understand how anemia develops in these infected mice, which might help us understand how symptoms of HLH develop," said Detweiler. The syndrome can be difficult to recognize and diagnose, she added.

"The availability of this animal model for HLH will help to advance the research and understanding of the underlying mechanisms of this immune system disorder," said Detweiler. "It also should provide a means to test new therapies for HLH."


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Contact: Diane Brown
diane.brown@colorado.edu
University of Colorado at Boulder
Source:Eurekalert

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