Navigation Links
New University of Colorado paper shows novel way to study human inflammatory disease
Date:2/25/2010

A new University of Colorado at Boulder study shows mice infected with the bacteria salmonella develop clinical signs consistent with a deadly and poorly understood human inflammatory disease, a finding that may lead to new therapies.

The human disease, known as Hemophagocytic Lymphohistiocytosis, or HLH, is a rare inflammatory disease that kills between 50 percent and 90 percent of its victims, said Diane Brown, lead author of the study. HLH treatment may require bone marrow transplantation, a drastic therapy with life-long consequences, according to Brown, adjoint curator at the University of Colorado Museum of Natural History.

The disease, in which the immune system becomes hyperactivated, occurs both in an inherited form, known as primary HLH, and in people with no known genetic defect, known as secondary HLH. Both forms are usually triggered by infections. The genetic form of HLH most often strikes infants and very young children.

A paper on the subject is being published Feb. 26 in PLoS One, a journal of the Public Library of Science. Study co-authors, all from CU-Boulder's molecular, cellular and developmental biology department, included Assistant Professor Corrella Detweiler, postdoctoral fellows Melissa McCoy and Carolina Pilonieta, and former master's student Rebecca Nix, now at Supergen in Salt Lake City. The study was funded by the National Institutes of Health and the American Recovery and Relief Act.

Salmonella is a well-known food contaminant, causing a variety of gastrointestinal tract symptoms in humans. While mice infected with salmonella are spared the cramping and diarrhea that humans develop, they were shown to develop a disease syndrome comparable to human secondary HLH, said Brown.

The CU-Boulder research team found that mice infected with salmonella developed fever, enlarged spleens, anemia, reduced numbers of platelets, dangerously high blood levels of an iron-storage protein,
'/>"/>

Contact: Diane Brown
diane.brown@colorado.edu
University of Colorado at Boulder
Source:Eurekalert

Page: 1 2

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Carbon offsetting initiatives could be improved with new insights ... , Scientists studying the Amazon Basin have revealed ... trees across the region by comparing satellite maps with ... enable researchers to assess more accurately the amount of ... factor in carbon offset schemes, in which trees are ...
(Date:4/23/2014)... analysis of NASA satellite data shows Africa,s Congo rainforest, ... a large-scale decline in greenness over the past decade. ... at Albany, State University of New York, shows between ... of forest area and intensified. The research, published Wednesday ... comprehensive observational studies to explore the effects of long-term ...
(Date:4/23/2014)... from the Indiana University School of Public Health-Bloomington has ... disease by finding a strong association between heme iron, ... disease. , The study found that heme iron consumption ... percent, while no association was found between nonheme iron, ... coronary heart disease. , The study was published online ...
Breaking Biology News(10 mins):Amazon rainforest survey could improve carbon offset schemes 2NASA satellites show drought may take toll on Congo rainforest 2NASA satellites show drought may take toll on Congo rainforest 3Study: Iron consumption can increase risk for heart disease 2
... , NEW YORK (Nov. 3, 2010) -- Scientists at Weill ... better understanding of prostate cancer by uncovering evidence that it ... factors which can be measured and, in the future, destroyed ... research team led by of Dr. Mark A. Rubin, the ...
... and Columbia University Medical Center have been awarded a ... B. Helmsley Charitable Trust, establishing a collaborative program to ... to gain new insight into disease mechanisms and screen ... of immense importance to the future of biomedical research ...
... defects in plants can be predicted based on chromosome ... the addition or deletion of genes and the organization ... involving a Purdue University researcher. The findings identify ... chromosomes, said Brian Dilkes, a Purdue assistant professor of ...
Cached Biology News:Prostate cancer's multiple personalities revealed 2Helmsley Charitable Trust awards more than $15 million to Salk Institute-CUMC 2Helmsley Charitable Trust awards more than $15 million to Salk Institute-CUMC 3Chromosome imbalances lead to predictable plant defects 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
(Date:1/15/2014)... 2014 DTS Language Services, Inc . ... Portal for Life Science organizations who need document translations. ... matter of their documents in advance with a selection of ... of translations, often a critical factor in clinical and scientific ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Scott Stevens, Ph.D. , ... Scott Stevens, Ph.D ., assistant professor of molecular ... at Austin,1 University Station, #A4800,2500 Speedway,Austin,TX , ... scott.stevens@mail.utexas.edu. , ...
... By Julia Cino, PhD ... Introduction , ... to manipulate DNA to identify,excise, move and place genes into a variety ... use for many of these recombinant organisms is to produce,proteins. Since many ...
... , , ... , This Application Report ... BioFlo 110,benchtop fermentor/bioreactor system. The modular,BioFlo 110 is offered with ... wide variety of cultures, including mammalian, insect,plant, yeast and bacterial cells. Complete ...
Cached Biology Technology:Fermentation Cell Culture: University Style 2Fermentation Cell Culture: University Style 3Fermentation Cell Culture: University Style 4Fermentation Cell Culture: University Style 5Fermentation Cell Culture: University Style 6Fermentation Cell Culture: University Style 7Fermentation Cell Culture: University Style 8Fermentation Cell Culture: University Style 9High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 2High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 3High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 4High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 5High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 6High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 7High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation 8Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 2Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 3Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 4Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 5Hybridoma Cell Culture Application Using a BioFlo 110 Benchtop Bioreactor 6
Immunochemistry 1 & 2...
Hucal Agx Antigen Expression Service Specificity: Hucal Agx ...
... The 1-D PAGE ... Kit for Targeted Protein ... SDS PolyAcrylamide Gel Electrophoresis ... chemistry, and cleavable-linker technology ...
Antibody Purification Specificity: Antibody Purification ...
Biology Products: