Navigation Links
New Stanford tool enables wider analyses of genome 'deep sequencing'
Date:5/2/2010

STANFORD, Calif. - Life is almost unbearably complex. Humans and mice, frogs and flies toggle genes on and off in dizzying combinations and sequences during their relentless march from embryo to death. Now scientists seeking to understand the machinations of the proteins behind the genomic wizard's screen have a powerful new tool at their disposal, courtesy of researchers at the Stanford University School of Medicine.

Until now, researchers have relied on outdated methods of analysis to identify those DNA sequences involved in controlling when and how individual genes are expressed. Most often, those methods - capable of probing only specific, limited regions of the genome arising from a type of experiment called DNA microarrays - led to the exclusive scrutiny of regions called promoters nestled near the start of the gene.

In contrast, the new Stanford-developed, web-based algorithm allows scientists to plumb the unprecedented depths of the data provided by new "deep-sequencing" techniques to reveal a pantheon of control regions for nearly any gene. The effect is like expanding a researcher's field of vision from a pencil-thin beam of light trained mainly on the regions near coding sequences to a sweeping spotlight illuminating the contributions of distant genomic regions.

"It used to be that people thought only the regions near the gene were important in controlling its function - in part because they had no way of assessing the impact of regions further away," said Gill Bejerano, PhD, assistant professor of developmental biology and of computer science at the medical school and Stanford's School of Engineering.

As a result, said Bejerano, researchers often cherry-picked nearby regions for further analysis based on their proximity or interest. "But when you're being that conservative with current sequencing capabilities, you're typically throwing away at least half of the data you so laboriously worked to obtain," he said.'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Americans remain pessimistic about the environment, Stanford-AP survey finds
2. Stanford/Packard researchers find disease genes hidden in discarded data
3. Stanford researchers say climate change will significantly increase impending bird extinctions
4. Stanfords nanowire battery holds 10 times the charge of existing ones
5. Stanford researchers publish review of US medical device regulation
6. Stanford researchers make first direct observation of 3-D molecule folding in real time
7. Stanford researchers say living corals thousands of years old hold clues to past climate changes
8. Group led by Stanford physicist says theres an urgent need for nuclear detectives
9. Stanford researchers developing 3-D camera with 12,616 lenses
10. Clues to ancestral origin of placenta emerge in Stanford study
11. Inflammation triggers cell fusions that could protect neurons, Stanford research shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
(Date:3/24/2015)... , March 24, 2015   Crossmatch ™, ... today announced that its U.are.U ® 4500 ... Goorin Bros . to achieve PCI compliance ... secures access to the POS terminal, protecting the ... of data breaches. With one-third ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... why premature birth is a growing problem in the United ... that pre-pregnancy depressive mood appears to be a risk factor ... however, have nearly two times the odds of having a ... a University of Washington assistant professor of social work and ...
... pregnant women hinders brain development in their children ... thyroid hormone levels in the fetal brain, a ... Wednesday at The Endocrine Society,s 91st Annual Meeting ... moderate drinking during pregnancycan cause neurodevelopmental disorders, such ...
... , This release is available in ... this is particularly true for cancer medicine. The ... further increased if research results are swiftly transferred from ... research transfer, also called translational research, will now be ...
Cached Biology News:Pre-pregnancy depressed mood may heighten risk for premature birth 2Pre-pregnancy depressed mood may heighten risk for premature birth 3Specific genetic cause of fetal alcohol-related developmental disorders found 2German Research Minister Schavan: 'Rapid knowledge transfer can safe lives' 2German Research Minister Schavan: 'Rapid knowledge transfer can safe lives' 3
(Date:5/4/2015)... Wheaton, Illinois (PRWEB) May 04, 2015 ... treatment options for patients with arm and hand ... rehabilitation exoskeleton at its Oakbrook Terrace network site. ... foundation, the Armeo®Spring is a highly-regarded treatment option ... In acquiring the Armeo®Spring, Marianjoy becomes one of ...
(Date:5/1/2015)... OncoTAb, Inc., a University ... announced that Pinku Mukherjee, Ph.D. has received the ... Governors’ highest faculty honor. Mukherjee received the award, which ... her innovative research and development of cancer diagnostics and ... crowning moment in my scientific career,” said Mukherjee, OncoTAb ...
(Date:5/1/2015)... DIEGO , May 1, 2015 ... company engaged in the development of biosimilar therapeutics ... announced today that its first quarter 2015 financial ... 2015, before the open of market. At 8:30 am ... call to discuss the financial results and provide ...
(Date:5/1/2015)... -- A new report by  visiongain  forecasts ... $22.4bn in 2019. That revenue forecast and others appear ... 2015-2025 ,  published in March 2015. ... forecasts and qualitative analyses of the antithrombotic drugs market. ... London, UK . It produces analyses ...
Breaking Biology Technology:Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5
... Pharmaceuticals, Inc. (Nasdaq: SVNT ) today announced ... approved KRYSTEXXA™ (pegloticase), a PEGylated uric acid specific enzyme ... patients refractory to conventional therapy.  Chronic gout that is ... failed to normalize serum uric acid and whose signs ...
... Calif., Sept. 14 The launch of IntriMed ... Innovation Center in Oxnard, Calif. were announced today ... design and manufacture of ultra-precise components for the ... 23 year heritage of engineering innovation, IntriMed ( ...
... (Nasdaq: BSTC ), a biopharmaceutical company developing ... President, Tom Wegman, will present at the upcoming UBS ... at 7:30am ET at the Grand Hyatt New York ... of the presentation can be accessed under "Calendar of ...
Cached Biology Technology:FDA Approves KRYSTEXXA™ (pegloticase) for the Treatment of Chronic Gout in Adult Patients Refractory to Conventional Therapy 2FDA Approves KRYSTEXXA™ (pegloticase) for the Treatment of Chronic Gout in Adult Patients Refractory to Conventional Therapy 3FDA Approves KRYSTEXXA™ (pegloticase) for the Treatment of Chronic Gout in Adult Patients Refractory to Conventional Therapy 4FDA Approves KRYSTEXXA™ (pegloticase) for the Treatment of Chronic Gout in Adult Patients Refractory to Conventional Therapy 5FDA Approves KRYSTEXXA™ (pegloticase) for the Treatment of Chronic Gout in Adult Patients Refractory to Conventional Therapy 6FDA Approves KRYSTEXXA™ (pegloticase) for the Treatment of Chronic Gout in Adult Patients Refractory to Conventional Therapy 7FDA Approves KRYSTEXXA™ (pegloticase) for the Treatment of Chronic Gout in Adult Patients Refractory to Conventional Therapy 8IntriMed Technologies Launched to Address Challenges Faced by Medical Device Manufacturers 2IntriMed Technologies Launched to Address Challenges Faced by Medical Device Manufacturers 3
Human ABCG2 MAb (Clone 5D3)...
... The Beacon 2000 One-Step FP ... characteristic high and low fluorescence polarization ... users of the Beacon 2000 System. ... the polarization values generated by their ...
...
... vitro cell labeling mix, 92.5 ... solution stabilized with 0.1% 2-mercaptoethanol ... 3,4-dicarboxylic acid. *Amino acid mixture ... containing l-[35S]Methionine and l-[35S]Cysteine. * ...
Biology Products: