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New Scripps Research and GNF study helps explain how we can sense temperatures
Date:4/23/2010

d that the mutations disrupting temperature sensitivity interfered with the long channel openings, but not the short ones.

"This study suggests a potential molecular mechanism that generates extreme temperature sensitivity from two mildly temperature sensitive steps," said Grandl. The team postulates that by stabilizing the open state, the pore domain contributes to thermosensitivity of TRPV1. "We now have a novel working model of how Nature could have evolved such exquisite temperature sensitivity, a hypothesis that can be tested in future work."


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Contact: Keith McKeown
daphne@san.rr.com
858-784-8134
Scripps Research Institute
Source:Eurekalert

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