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New ORNL process brings nanoparticles into focus
Date:6/23/2008

benefits from all of the advantages of a standard atomic force microscope but provides access to some of the features buried inside the cell."

Ultimately, this new imaging capability could help advance the field of nanoparticles-cell interactions. In addition to the high-resolution subsurface imaging and localization of nanoparticles in biological samples, scanning near-field ultrasonic holography allows for minimal sample preparation and requires no labeling with radioisotopes. The technique also offers relatively high throughput sample analysis, which enables researchers to image many cells quickly.

"The scanning near-field ultrasonic holography method should be especially useful for determining the efficacy of cell type-specific drug targeting, which is a critical goal for medical uses of nanomaterial," wrote the authors, who expect their results to help resolve critical questions about the fate and potential toxicity of nanoparticles within the body.


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Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

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