Navigation Links
New ORNL process brings nanoparticles into focus
Date:6/23/2008

OAK RIDGE, Tenn., June 23, 2008 Scientists can study the biological impacts of engineered nanomaterials on cells within the body with greater resolution than ever because of a procedure developed by researchers at the Department of Energy's Oak Ridge National Laboratory.

The method, detailed in the current issue of Nature Nanotechnology, uses scanning near-field ultrasonic holography to clearly see nanoparticles residing within cells of laboratory mice that had inhaled single-walled carbon nanohorns. Nanohorns are short, horn-shaped tubular structures capped with a conical tip.

"While carbon-based materials have countless potential uses, we need to know how they interact within a cell and whether they are able to penetrate cells," said Laurene Tetard, lead author and a member of ORNL's Biosciences Division. "We found that these nanohorns can indeed get into cells."

With this new tool, researchers will be able to determine whether a cell's shape changes because of nanomaterials such as the nanohorns used for this study. Tetard and co-authors expect this work to be of significant benefit to scientists studying drug delivery systems, nanotoxicology and interactions between engineered nanomaterials and biological systems.

"The rising commercial use of engineered nanoparticles and the ensuing need for large-scale production pose a risk of unintended human exposure that may impact health," the authors wrote. "Central to this issue is the ability to determine the fate of nanoparticles in biological systems and in more details their route after inhalation."

In contrast to conventional imaging techniques, scanning near-field ultrasonic holography provides a detailed look inside a cell, providing nanometer resolution.

"Conventional atomic force microscopy using a cantilever tip can only probe the surface of a specimen, making it difficult to analyze structures that are inside a cell," Tetard said. "Our method benefits from all of the advantages of a standard atomic force microscope but provides access to some of the features buried inside the cell."

Ultimately, this new imaging capability could help advance the field of nanoparticles-cell interactions. In addition to the high-resolution subsurface imaging and localization of nanoparticles in biological samples, scanning near-field ultrasonic holography allows for minimal sample preparation and requires no labeling with radioisotopes. The technique also offers relatively high throughput sample analysis, which enables researchers to image many cells quickly.

"The scanning near-field ultrasonic holography method should be especially useful for determining the efficacy of cell type-specific drug targeting, which is a critical goal for medical uses of nanomaterial," wrote the authors, who expect their results to help resolve critical questions about the fate and potential toxicity of nanoparticles within the body.


'/>"/>

Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

Related biology news :

1. ID Solutions Awarded Full-Production Order for Fingerprint Processing Software for TWIC
2. Forum to focus on math and mechanics behind life processes
3. Researchers discover architecture for fundamental processes of life
4. Expanded histology methods book covers processing of animal, plant, and microbial tissues
5. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
6. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
7. New horizons in modelling surface processes
8. NYU scientists set stage for understanding how color vision is processed
9. Using ground-penetrating radar to observe hidden underground water processes
10. Substantial improvement in essential cheap solar cell process
11. New process makes nanofibers in complex shapes and unlimited lengths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... CHICAGO , Nov. 30, 2016  higi ... a new partnership initiative targeting national brands, industry ... and reward their respective audiences for taking steps ... Since its inception in 2012, higi has built ... US, impacting over 38 million people who have ...
(Date:11/29/2016)... , Nov. 29, 2016   Neurotechnology ... and object recognition technologies, today released FingerCell ... fingerprint recognition solutions that run on low-power, ... template using less than 128KB of memory, ... devices that have limited on-board resources, such ...
(Date:11/28/2016)... 28, 2016 "The biometric ... 16.79%" The biometric system market is in the ... the near future. The biometric system market is expected ... at a CAGR of 16.79% between 2016 and 2022. ... biometric technology in smartphones, rising use of biometric technology ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016  Renova™ Therapeutics, a ... heart failure and other chronic diseases, announced that ... company as Chief Financial Officer (CFO), effective today. ... 20 years of experience in financial management for ... and software companies. Most recently, Ms. Bovenizer was ...
(Date:12/5/2016)... DUBLIN , Dec 5, 2016 ... new report "DNA Sequencing - Technologies, Markets and Companies" ... ... This report briefly reviews basics of human genome variations, development ... sequencers are described as well as companies developing them. Various ...
(Date:12/4/2016)... 2016  In five studies being presented today during ... and Exposition in San Diego , ... the delivery of life-saving treatments to patients with a ... to carry therapies directly to the sites in the ... a substantial advantage over traditional, systemic methods. The studies ...
(Date:12/2/2016)... Conn. , Dec. 2, 2016  The Multiple ... presentations from the MMRF CoMMpass Study SM —the largest ... accelerating precision medicine in multiple myeloma—will be presented at ... Annual Meeting & Exposition in San Diego ... helping to optimize treatment strategies, as well as identify ...
Breaking Biology Technology: