Navigation Links
New NIST web tool makes working with glycan sugars a lot sweeter
Date:7/11/2014

When researchers at the National Institute of Standards and Technology (NIST) need a special tool to do their work more effectively, they often prove that necessity is truly the mother of invention. Such was the case recently for M. Lorna De Leoz and Stephen Stein, NIST chemists working in the growing specialization of glycomics. Glycomics is the study of the abundant, often-branched sugar chains called glycans that are attached to proteins and lipids and influence cellular processes, including immunity, protein folding and, sometimes, changes associated with cancer.

Like their fellow scientists in the glycomics field, De Leoz and Stein rely heavily on mass spectral (MS) analyses that yield "chemical fingerprints" used to characterize the mass, composition and organization of individual glycan molecules. The human body produces thousands of different glycans and, unfortunately, MS analysis is slow and laborious, involving lots of number crunching by hand. Out of their frustration with this low-tech system for calculating high-tech MS data, the NIST duo came up with a tool that automates most of the process.

Their new Glyco MS Calculator automatically determines the mass of individual glycan components and breaks them down element-by-element. Designed in a spreadsheet format, the user inputs the number of residues (the individual units that make up a polymer; in this case, the monosaccharide sugars in the polysaccharide chain) in the glycan and the program calculates the masses and elemental composition within the molecule. It also provides mass and composition for glycans that are chemically modified. Finally, the calculator generates the mass of molecules formed as byproducts of mass spectrometry so that they can be considered when interpreting the MS data.


'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1

Related biology news :

1. UH chemical engineer makes device fabrication easier, thanks to NSF grant
2. #Sexychem: 4 ways chemistry makes sex safe -- and spicy (video)
3. New, fossil-fuel-free process makes biodiesel sustainable
4. Researchers test whether Red Queen hypothesis makes species resilient
5. GaitTrack app makes cellphone a medical monitor for heart and lung patients
6. Novel antioxidant makes old arteries seem young again, CU-Boulder study finds
7. Simply being called fat makes young girls more likely to become obese
8. How vision makes sure that little fish do not get carried away
9. Sport makes muscles and nerves fit
10. New stratigraphic research makes Little Foot the oldest complete Australopithecus
11. What makes flying snakes such gifted gliders?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New NIST web tool makes working with glycan sugars a lot sweeter
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... to grow at a CAGR of 30.37% during the period 2017-2021. ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... , ... May 23, 2017 , ... ... this month its 20th anniversary, marking the occasion with a strong presence at ... meeting’s Welcome Reception and further extends an invitation to all attendees to view ...
(Date:5/23/2017)... , ... May 22, 2017 , ... ... Photonics 2017 in San Diego, California, this August will feature high-level speakers ... and autonomous vehicles. , SPIE Optics and Photonics, the largest multidisciplinary optical sciences ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... technology applications, has announced a facility expansion to accommodate its rapid growth. , ... of new workspace and renovation of the existing areas. The expansion includes, a ...
(Date:5/23/2017)... ... May 23, 2017 , ... Bacterial biofilms, surface adherent ... can cause diverse pathologies ranging from food poisoning and catheter infections to gum disease ... in the tens of billions of dollars per year, there is currently a paucity ...
Breaking Biology Technology: