Navigation Links
New NIH grant helps MU scientist get to the heart of muscular dystrophy
Date:12/6/2010

Children with Duchenne muscular dystrophy (DMD) face a future of rapidly weakening muscles, which usually leads to death by respiratory or cardiac failure before their 30th birthday. While researchers are hopeful that gene therapy could eventually evolve into an effective treatment, few have targeted the heart of the problem as much as Dongsheng Duan, PhD.

Duan hopes a new $2.1 million grant he received from the National Institutes of Health will help him develop a treatment that prevents heart muscles from weakening as a result of DMD. As many as 40 percent of patients with the inherited disorder die from heart failure because their weakened cardiac muscles can't pump enough blood to sustain life.

Children with DMD, which is often seen in boys, experience weakening of both skeletal muscle and heart muscle due to a defective gene for dystrophin, a type of muscle protein. Researchers have developed a synthetic dystrophin gene that has shown to be effective in treating skeletal muscle, but Duan's findings published in the journal Molecular Therapy show that cardiac muscle requires different treatment. In fact, tests in an animal model have shown that treating skeletal muscle alone while leaving cardiac muscle untreated can lead to serious complications: Stronger skeletal muscles mean patients can be more physically active, which requires a stronger heart to pump blood throughout the body.

"We've demonstrated that the gene therapy that works for the skeletal muscle doesn't necessarily work for the heart," Duan said. "If we want a more comprehensive treatment, we cannot ignore how the disease affects cardiac muscle."

Duan's lab has analyzed data on thousands of patients with DMD to identify common patterns in deletions on the dystrophin gene that could have led to heart-specific muscle weakness. Now the researcher is developing a new synthetic gene that he hopes will comprehensively treat muscles weakened by DMD.

"We're
'/>"/>

Contact: Natalie Fieleke
fieleken@health.missouri.edu
573-884-7541
University of Missouri School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. $4.3 million DARPA grant enables development of biological and chemical threat detector
2. New Scripps Florida scientist awarded pair of unconventional grants
3. VaxTrac Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research
4. Aeras awarded €11.7 million ($16 million) grant from Dutch government
5. Unconventional idea for antiviral contraceptive gel wins Gates Foundation grant
6. Undergraduates low-cost ultrasound system wins Gates Foundation grant
7. $12 million grant to probe root causes of heart failure
8. Landenberger Foundation awards grant to Scripps Florida scientist to study HIV
9. NSF awards $3.75 million grant to New York Plant Genome Consortium for the creation of BigPlant v1.0
10. NSF awards grants for research on coupled natural and human systems
11. Universities receive grants to study climate change decisions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... DETROIT In order to support the world,s ... chemicals, polymers and more, new and more efficient ... team of researchers, including several from Wayne State ... of a new grant from the National Science ... Guided Design of Multicomponent Materials for Electrocatalytic Cascade ...
(Date:9/29/2014)... Scientists at Washington State University have concluded ... Smith apples may help prevent disorders associated ... first to assess these compounds in apple cultivars ... print edition of the journal Food Chemistry ... a good source of these nondigestible compounds but ...
(Date:9/29/2014)... Santos has presented Dr. Cristin Samper, president and ... prestigious Order of San Carlos. , The Order ... and military officers who have made outstanding contributions ... international relations. , An international authority on conservation ... to the Colombian Residence in New York to ...
Breaking Biology News(10 mins):Wayne State research aims to develop new, more efficient catalytic materials 2An apple a day could keep obesity away 2
... Interventional Radiology hailed the Sept. 11 decision by ... has oversight of the 24 recognized medical specialty ... for a new Dual Primary Certificate in Interventional ... and its member boards confirmed the benefit to ...
... JEJU, REPUBLIC OF KOREA (September 12, 2012) A ... biologically diverse place on earth, according to the Wildlife ... list of species found there. The announcement was ... gathering of conservationists meeting through Sept. 13 in Jeju, ...
... a man with apparent battle wounds and curvature of the ... the University of Leicester. The University of Leicester has ... King Richard III with Leicester City Council, in association with ... third week, has yielded dramatic findings of human remains which ...
Cached Biology News:Society of Interventional Radiology hails affirmation of specialty's role in patient care 2Society of Interventional Radiology hails affirmation of specialty's role in patient care 3Society of Interventional Radiology hails affirmation of specialty's role in patient care 4Amazing diversity documented in national park 2King Richard III search in new phase after 'discovery has potential to rewrite history' 2King Richard III search in new phase after 'discovery has potential to rewrite history' 3King Richard III search in new phase after 'discovery has potential to rewrite history' 4King Richard III search in new phase after 'discovery has potential to rewrite history' 5King Richard III search in new phase after 'discovery has potential to rewrite history' 6King Richard III search in new phase after 'discovery has potential to rewrite history' 7King Richard III search in new phase after 'discovery has potential to rewrite history' 8King Richard III search in new phase after 'discovery has potential to rewrite history' 9
(Date:9/29/2014)... , Sept. 29, 2014  The 12th ... officially kicks off September 29 at the John ... over Boston for a weeklong ... Cold Chain Global Forum is designed to cover the ... the modern cold chain, all temperature range products, GDP ...
(Date:9/29/2014)... 29, 2014  Perrigo Company plc (NYSE: ... has transferred a portfolio of preclinical research assets, ... of Elan Corporation plc, to drug discovery and ... agreement, Perrigo will receive an upfront payment in ... on any future sales derived from the portfolio. ...
(Date:9/29/2014)... , Sept. 29, 2014  Xcenda, the strategic ... global pharmaceutical sourcing and distribution service companies, recently ... consumption. This research was analyzed in an economic ... associated with an increase in life years and ... at population-level coffee consumption across the ...
(Date:9/29/2014)... 29, 2014 Westbridge Agricultural Products ... EC, a highly effective new tool for organic ... broad spectrum contact herbicide for post-emergent, non-selective weed ... non-food crops. The formulation is an emulsifiable concentrate ... Review Institute (OMRI) for use in organic food ...
Breaking Biology Technology:12th Cold Chain GDP & Temperature Management Logistics Global Forum Officially Kicks Off in Boston 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 3Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 4Coffee Consumption May Increase Survival and Reduce Healthcare Costs 2Coffee Consumption May Increase Survival and Reduce Healthcare Costs 3Westbridge Receives EPA Approval for Its New SUPPRESS™ Herbicide EC 2
... 29, 2012 Cell Therapeutics, Inc. ("CTI") (Nasdaq and MTA: ... to sell, subject to customary closing conditions, $40 million of ... to purchase shares of its common stock (and the shares ... of the Series 15 Convertible Preferred Stock and exercise and ...
... and TARRYTOWN, New York, May 26, 2012 ... SNY ) and Regeneron Pharmaceuticals, Inc. (NASDAQ: ... a Phase 2 trial of SAR236553/REGN727 (Study 1003, ... SAR236553/REGN727 is a subcutaneously administered, fully-human antibody targeting ...
... known that a diet high in fat and extremely low ... But how the diet worked, and why, was a mysteryso ... called it "Epilepsy,s Big, Fat Miracle." Now, researchers ... an answer, linking resistance to seizures to a protein that ...
Cached Biology Technology:Cell Therapeutics Announces Institutional Investor to Purchase $40 Million of Convertible Preferred Stock and Warrants to Purchase Common Stock 2Cell Therapeutics Announces Institutional Investor to Purchase $40 Million of Convertible Preferred Stock and Warrants to Purchase Common Stock 3Cell Therapeutics Announces Institutional Investor to Purchase $40 Million of Convertible Preferred Stock and Warrants to Purchase Common Stock 4Cell Therapeutics Announces Institutional Investor to Purchase $40 Million of Convertible Preferred Stock and Warrants to Purchase Common Stock 5Cell Therapeutics Announces Institutional Investor to Purchase $40 Million of Convertible Preferred Stock and Warrants to Purchase Common Stock 6Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 2Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 3Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 4Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 5Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 6Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 7Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 8Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 9Reverse engineering epilepsy's 'miracle' diet 2Reverse engineering epilepsy's 'miracle' diet 3
... PolarScreen Progesterone Receptor (PR) Competitor ... or screening novel progesterone receptor binding ... homogenous assay utilizes a fusion of ... domain of human progesterone receptor [PR-LBD(GST)] ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential CV/Renal liabilities of compounds....
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential Neurological liabilities of compound...
... form from a hematopoietic stem cells called ... the bone surface and lowering the surrounding ... 4.5. The bone mineral is then solubilized ... function is controlled primarily by Macrophage Colony-Stimulating ...
Biology Products: