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New NIH awards focus on nanopore technology for DNA sequencing
Date:9/6/2013

l time. They will construct large arrays of nanopores to create DNA sequencing chips, enabling them to determine DNA bases during a specific biochemical reaction. They hope this technique will enable them to read large sections of DNA more accurately and rapidly than is now possible.

  • Eve Biomedical, Inc., Mountain View, Calif., $493,000 over two years (pending available funds)
    Principal Investigator: Theofilos Kotseroglou, Ph.D.

    Dr. Kotseroglou's research team intends to develop a DNA sequencing system that can sequence an entire human genome for under $100. The overall system will be based on using light to sequence DNA on a cell phone camera chip. For now, his group plans to continue studying ways to accurately read long sections of DNA and develop software tools and bioinformatics.

  • University of Massachusetts, Amherst, $1.07 million over four years (pending available funds)
    Principal Investigator: Murugappan Muthukumar, Ph.D.

    Dr. Muthukumar's research group plans a theoretical approach to study several major challenges underlying nanopore-based DNA sequencing, including slowing down the rate at which DNA molecules flow through the pores, the effects of specific ions, changes in the shape of the DNA molecule and other aspects of the environment.

  • University of North Carolina at Chapel Hill, $2.05 million over four years (pending available funds)
    Principal Investigator: John Michael Ramsey, Ph.D.

    Dr. Ramsey and his co-workers plan to develop a low-cost method for rapidly mapping individual genomes. Such maps will help determine how large mutations in DNA structure contribute to human disease and improve diagnostic testing using genomics.

  • Electronic Biosciences, Inc., San Diego, $239,000
    Principal Investigator: Anna Schibel, Ph.D.

    Dr. Schibel and her co-workers will develop chemical methods to slow the rate by which single-stranded DNA m
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  • Contact: Steven Benowitz
    steven.benowitz@nih.gov
    301-451-8325
    NIH/National Human Genome Research Institute
    Source:Eurekalert

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