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New NIH awards focus on nanopore technology for DNA sequencing
Date:9/6/2013

chip for under $100.

The new grants are awarded to:

  • University of Illinois, Urbana-Champaign, $2.47 million over four years (pending available funds)
    Principal Investigator: Oleksii Aksimentiev, Ph.D.

    Dr. Aksimentiev and his colleagues plan to use nanopores as sensors. The researchers are studying the effects of combining synthetic nanopores with a light-based technique to control the flow of DNA molecules through the pores. They will use a type of spectroscopy to read the chemical sequence of the DNA.

  • University of New Mexico Health Sciences Center, Albuquerque, $1.35 million over three years (pending available funds)
    Principal Investigator: Jeremy Edwards, Ph.D.

    Dr. Edwards and his colleagues plan to develop innovative molecular biology tools to improve whole-genome sequencing, which entails reading a person's entire genetic blueprint. The researchers hope that better methods of preparing the DNA molecules for sequencing will help scientists identify and link genetic variants to disease and, ultimately, lead to new treatments.

  • University of Washington, Seattle, $3.83 million over four years (pending available funds)
    Principal Investigator: Jens Gundlach, Ph.D.

    The researchers plan to continue developing the use of nanopore DNA sequencing technology involving a type of protein nanopore called MspA. Part of their research will focus on improving the control of movement of DNA through the nanopore and on developing algorithms to identify DNA bases.

  • Columbia University, New York City, $5.25 million over three years (pending available funds)
    Principal Investigators: Jingyue Ju, Ph.D., George M. Church, Ph.D., (Harvard Medical School, Boston) and James John Russo, Ph.D. (Columbia University, New York City)

    Dr. Ju and his colleagues plan to develop a miniaturized electronic system using nanopores to analyze single molecules of DNA in rea
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Contact: Steven Benowitz
steven.benowitz@nih.gov
301-451-8325
NIH/National Human Genome Research Institute
Source:Eurekalert

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