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New NIH/NHGRI grants to harness nanoscale technologies to cut DNA sequencing costs
Date:9/14/2012

des and approaches for manipulating DNA molecules with great precision by using nanoscale structures," noted Jeffery A. Schloss, program director for NHGRI's Advanced DNA Sequencing Technology Program.

The 2012 awards are:

Genapsys, Inc., Redwood City, CA.
Hesaam Esfandyarpour, Ph.D.
Funding amount: $1.2 million in fiscal 2012 (total $3.3 million over three years subject to the availability of appropriations)
Aim: Develop easy-to-use, chip-based DNA sequencing that combines multiple sample processing steps with sequencing in a single device called the Gene Electronic Nano-Integrated Ultra-Sensitive platform.

Harvard University, Cambridge, Mass.
Jene Golovchenko, Ph.D., and Daniel Branton, Ph.D.
Funding amount: $1.2 million in fiscal 2012 (total $3.6 million over three years subject to the availability of appropriations)
Aim: Develop a scalable graphene nanopore sequencing device that will identify DNA subunits on unlabeled, single-stranded genomic DNA molecules. Graphene is a special arrangement of a single layer of carbon atoms. The nanopore is a hole in the graphene about two nanometers in diameter.

GnuBIO, Inc., Cambridge, Mass.
Tal Raz, Ph.D., with David Weitz, Ph.D., Harvard University
Funding amount: $1.5 million fiscal 2012 (total $4.5 million over three years subject to the availability of appropriations)
Aim: Increase the throughput of the current single channel microfluidic instrument to enable whole genome sequencing in about six hours, including data analysis, genome alignment and variant calling. Microfluidics refers to plastic devices in which fluids move through tiny channels that are the diameter of a human hair.

Columbia University, New York City
Kenneth Shepard, Ph.D., with Marija Drndic, Ph.D., University of Pennsylvania, Philadelphia
Funding amount: $500,000 in FY2012 (total $1.5 million over three ye
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Contact: Omar McCrimmon
mccrimmono@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

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