Navigation Links
New MRI technique could mean fewer breast biopsies in high-risk women
Date:6/29/2009

MADISON A University of Wisconsin-Madison biomedical engineer and colleagues have developed a method that, applied in MRI scans of the breast, could spare some women with increased breast cancer risk the pain and stress of having to endure a biopsy of a questionable lump or lesion.

The universal technology will give radiologists greater confidence in visually classifying a lesion as malignant or benign.

The American Cancer Society recommends that women with certain breast cancer risk factors including inherited genetic mutations, family or personal history of breast cancer, or previous radiation therapy to the chest receive an annual MRI screening in addition to their yearly mammogram.

During a breast MRI, which lasts about a half hour, the technician injects a contrast agent into a vein in the patient's arm. Over time, the contrast agent flows throughout the body, including the breasts. Because they are growing quickly, cancerous lesions often have immature vasculature, and the contrast agent flows in and "leaks" out quickly. Conversely, benign lesions show more gradual in and out flow.

"The tricky ones are the ones that enhance quickly and then fall off more slowly," says Wally Block, a UW-Madison associate professor of biomedical engineering and medical physics. "Many of these lesions turn out to be difficult to classify and lead to biopsy."

Yet, it turns out that with the right kind of MRI scan, radiologists can visually identify a cancerous lesion based on characteristics about its shape. For example, breaks or interruptions in a lesion can indicate a benign fibroadenoma. Lumps with smooth edges often are benign, while those with jagged edges can signal cancer.

To generate the kind of crisp, three-dimensional images necessary for such a diagnosis, Block, UW-Madison radiology associate professor Fred Kelcz and graduate student Catherine Moran are capitalizing on their unique MRI data-acquisition method.

An MR image is made up of thousands of smaller pieces of information. The conventional data-acquisition method gathers that information slowly, and it's designed to be viewed from a single imaging plane. "What people do now is they compromise," says Block. "They don't get resolution in the other planes to make it a reasonable scan time. We found a way around that."

With the team's powerful technique, an MRI machine acquires data radially and generates a high-resolution, three-dimensional image that radiologists can turn, slice and view from many perspectives enabling them to study a lesion's physical characteristics more carefully. Machines equipped with the technique also acquire more data in less time.

In addition, the method also makes it possible for radiologists to view fat images and water images separately, which is particularly useful because fat composes a large portion of the breast. "Rarely is disease associated with fat," says Block. "Most of the time radiologists are concentrating on water images, but sometimes our fat images of the breast are also useful. The boundaries of a lesion often stand out very clearly when embedded in fat."

Block and his colleagues currently are gathering data on the efficacy of the technique. They have tested the method on 20 patients at the University of Wisconsin Hospital and have shared it with colleagues at the University of Toronto for additional assessment. They also are working with Michigan State University researchers to test the technique.

Collaborating with Scott Reeder, a UW-Madison assistant professor of biomedical engineering and radiology, Block and colleagues also are refining ways to image both breasts simultaneously a development that could slash scan time and free valuable MRI space for additional patients. "If you have a screening procedure that you want people to participate in regularly, you want to make it convenient for them," says Block.


'/>"/>

Contact: Walter Block
wfblock@wisc.edu
608-265-9686
University of Wisconsin-Madison
Source:Eurekalert

Related biology news :

1. Can a new implant coating technique create a new six million dollar man?
2. Ovarian transplantation: First baby is born after a new technique
3. Ovarian transplantation: New technique gives greatly improved results in this delicate operation
4. Colon cancer screening technique shows continued promise in new study
5. Beating heart machine expedites research and development of new surgical tools, techniques
6. New genomic technique uncovers coral transcriptome
7. Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique
8. Indigenous peoples at world summit to share climate change observations, coping techniques
9. New high-throughput screening technique makes probing puzzling proteins possible
10. New technique used to profile anthrax genome
11. New aerosol observing technique turns gray skies to blue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/19/2016)... , Nov. 18, 2016 Securus Technologies, ... solutions for public safety, investigation, corrections and monitoring, announced ... smaller competitor, ICSolutions, to have an independent technology judge ... the most modern high tech/sophisticated telephone calling platform, and ... customers that they do most of what we do ...
(Date:11/15/2016)...  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... gut microbiome, today announced the pricing of an ... common stock and warrants to purchase 50,000,000 shares ... the public of $1.00 per share and accompanying ... offering, excluding the proceeds, if any from the ...
(Date:6/27/2016)... Research and Markets has announced the addition of the ... The report forecasts the biometrics ... a CAGR of 12.28% during the period 2016-2020. ... with inputs from industry experts. The report covers the market landscape ... includes a discussion of the key vendors operating in this market. ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... MA (PRWEB) , ... December 02, 2016 , ... Robots ... Light Event on December 3rd, 2016. The event, which is held on the ... work with helping Americans with Disabilities back into the workplace. Suitable Technologies is partnering ...
(Date:12/2/2016)... December 2, 2016 The immunohistochemistry (IHC) ... at a CAGR of 7.3% during the forecast period of 2016 ... diagnostic laboratories segment accounted for the largest share of immunohistochemistry (IHC) ... , ... global immunohistochemistry (IHC) market spread across 225 pages, profiling 10 companies ...
(Date:11/30/2016)... ... November 30, 2016 , ... BEI Kimco, a brand ... a flexure design that ensures high alignment accuracy by preventing unwanted shaft rotation. ... suited where extreme precision is required, such as in medical equipment, laboratory instrumentation, ...
(Date:11/30/2016)... , November 30, 2016 ... a few players hold a dominant share in the ... River Laboratories International, Inc., and Merck KGaA, held a ... 2015. Transparency Market Research observes that these companies are ... on development products that are do not require rabbit ...
Breaking Biology Technology: