Navigation Links
New MIT tool probes brain circuits
Date:1/24/2008

vigation. In Alzheimer's disease, the hippocampus is one of the first regions to suffer damage; memory problems and disorientation are among the disease's first symptoms.

The hippocampus is made up of several regions--CA1, CA3 and the dentate gyrus--that are wired up with distinct pathways.

The MIT study sought to determine how the interactions between neural pathways and the hippocampal regions affect learning and memory tasks.

Imagine that the three hippocampal regions are computers, and neural pathways are the conduits through which the computers get data from all over the brain. The computers perform different tasks, so the types of data processing will depend on which conduits the data travels through.

The hippocampus has two major, parallel information-carrying routes: the tri-synaptic pathway (TSP) and the shorter monosynaptic pathway (MSP). The TSP includes data processing from all three hippocampal regions, whereas the MSP skips through most of them.

Uisng DICE-K, the researchers were surprised to find that mice in which the major TSP pathway was shut down could still learn to navigate a maze. The shorter MSP pathway was sufficient for the job.

However, the maze is a task that is slowly learned over many repeated trials. When the mice were tested with a different task in a new environment that required rapid learning and memory formation, the researchers found that the mice with TSP shut down could not perform the task. Thus, the TSP pathway is required for animals to quickly acquire memories in a new environment. This kind of learning results in the most sophisticated form of memory that makes animals more intelligent and is known to decline with age, Tonegawa said.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Studying component parts of living cells with carbon nanotube cellular probes
2. Comet probes reveal evidence of origin of life, scientists claim
3. The human brain: Detective of auditory and visual change
4. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
5. MIT: Culture influences brain function
6. International scientists tackle obstacles to treating brain disorders
7. Why diving marine mammals resist brain damage from low oxygen
8. Biocapture surfaces produced for study of brain chemistry
9. Brain-computer link systems on the brink of breakthrough, study finds
10. Lipids in the brain an important factor for Alzheimers disease?
11. New studies suggest brain overgrowth in 1-year-olds linked to development of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 15, 2015  BellBrook Labs, a leader in high ... launch of a TR-FRET (time resolved Forster resonance ... Assay, a high throughput screening assay for glycosyltransferases ... allow for sensitive detection of hundreds of human ...
(Date:1/22/2015)... Jan. 21, 2015  Analyst Report Issued by Small Cap IR. ... showed that planet-wide, transactions at merchants on the leading payment ... number of credit, debit, and prepaid cards reached 6.54 billion.  ... of fraudulent card usage in 2012, and credit and debit ...
(Date:1/22/2015)... N.C. , Jan. 22, 2015 Infinisource has launched ... of the G2 model. The G2 sets a higher standard ... iSolved human capital management solution. With plug-and-play installation, touch screen ... time clock provides a robust time collection solution for the ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Infinisource's NXG series sets new time clock standard 2
... discovery of a new molecular signature for a destructive and ... therapeutic target for the hard-to-treat condition. In a study ... atresia, researchers report in the November Journal of Clinical ... the same disease process. Some patients have a second molecular ...
... Results of a study published this week in the journal ... to move to keep up with recent climate change effects in ... The study was supported by the National Science Foundation (NSF), ... and Synthesis at the University of California at Santa Barbara. ...
... MADISON, Wisconsin, November 7, 2011 A 79-year-old ... Northern Research Station are part of a team that ... years. Dan Lindner, a research plant pathologist with ... (CFMR), is one of 13 scientists participating in the ...
Cached Biology News:Possible treatment target found for main cause of severe liver disease in kids 2Possible treatment target found for main cause of severe liver disease in kids 3One if by land, Two if by sea? Climate change 'escape routes' 2Forest Service part of team sequencing 1,000 fungal genomes 2
(Date:1/22/2015)...  Transwestern | RBJ today announces the firm brokered a long-term ... a leading biopharmaceutical company, at Two Ledgemont Center in ... Richards , president, and Brian Cohen , senior vice ... building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... 2015 The laboratory information management systems ... a number of technological advancements due to factors such ... need to integrate healthcare systems, and increasing government support ... system integration. Key players in the market focus on ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... to be a fortune teller, but he believes his ... in radiation therapy for some time to come. , ... the Hi-Art System, the company's radiation therapy platform, will ... 250,000 patient fractions, or incremental treatments, have been delivered ...
... It's not too early to gauge the level of ... company formed by Beth Donley and University of ... already is rubbing elbows with interested investors, particularly angels, ... for eventually attracting big dollars from venture capitalists involves ...
... set forth predictions for 2007 is just too hard to resist. ... the next 12 months if you'll send me yours. Mine are ... to chris@guidewiregroup.com before the end of the week). So, ... away , ,Well, not Web 2.0 the development technique to ...
Cached Biology Technology:TomoTherapy sees sustained market advantage 2TomoTherapy sees sustained market advantage 3TomoTherapy sees sustained market advantage 4UW scientist, former WiCell director found stem cell company 2UW scientist, former WiCell director found stem cell company 3Bold prediction: Web 2.0 goes away in 2007 2Bold prediction: Web 2.0 goes away in 2007 3
ANTI-RAT ADHESION MARKERS, CDs, CYTOKINES, ETC Rat ICAM PE - Mouse IgG1...
Mouse monoclonal [050-04] to C2 ( Abpromise for all tested applications). entrezGeneID: 717 SwissProtID: P06681...
Reacts with methylated DNA from plants and vertebrates...
Rabbit polyclonal to Bag5 ( Abpromise for all tested applications). entrezGeneID: 9529 SwissProtID: Q9UL15...
Biology Products: