Navigation Links
New MIT tool probes brain circuits
Date:1/24/2008

CAMBRIDGE, Mass. - Researchers at the Picower Institute for Learning and Memory at MIT report in the Jan. 24 online edition of Science that they have created a way to see, for the first time, the effect of blocking and unblocking a single neural circuit in a living animal.

This revolutionary method allowed Susumu Tonegawa, Picower Professor of Biology and Neuroscience, and colleagues to see how bypassing a major memory-forming circuit in the brain affected learning and memory in mice.

Our data strongly suggest that the hippocampal neural pathway called the tri-synaptic pathway, or TSP, plays a crucial role in quickly forming memories when encountering new events and episodes in day-to-day life, Tonegawa said. Our results indicate that the decline of these abilities, such as that which accompanies neurodegenerative diseases and normal aging in humans, is likely to be due, at least in part, to the malfunctioning of this circuit.

Combining several cutting-edge genetic engineering techniques, Tonegawa's laboratory invented a method called doxycycline-inhibited circuit exocytosis-knockdown, or DICE-K-an acronym that also reflects Tonegawa's admiration of ace Boston Red Sox pitcher Daisuke Matsuzaka. DICE-K allows researchers for the first time to induce and reverse a blockade of synaptic transmission in specific neural circuits in the hippocampus.

The brain is the most complex machine ever assembled on this planet, Tonegawa said. Our cognitive abilities and behaviors are based on tens of thousands of molecules that compose several billion neurons, as well as how those neurons are connected.

One effective way to understand how this immensely complex cellular network works in a major form of cognition like memory is to intervene in the specific neural circuit suspected to be involved, he said.

Computing memories

The hippocampus, a seahorse-shaped brain region, plays a part in memory and spatial na
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Studying component parts of living cells with carbon nanotube cellular probes
2. Comet probes reveal evidence of origin of life, scientists claim
3. The human brain: Detective of auditory and visual change
4. Weill Cornell team discovers how brains own tPA helps regulate blood flow to neurons
5. MIT: Culture influences brain function
6. International scientists tackle obstacles to treating brain disorders
7. Why diving marine mammals resist brain damage from low oxygen
8. Biocapture surfaces produced for study of brain chemistry
9. Brain-computer link systems on the brink of breakthrough, study finds
10. Lipids in the brain an important factor for Alzheimers disease?
11. New studies suggest brain overgrowth in 1-year-olds linked to development of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... New York College, and one of the most prolific ... signals that are transmitted from Smartphones to third party ... Smartphones and has one of the earliest known patents ... its usage in the military, child care, elder care ...
(Date:11/21/2014)... 20, 2014 C-Labs LLC, a leading provider ... Things (IoT), today announced the appointment of John ... Previously a strategic advisor to the firm, Mr. Traynor ... Traynor is based out of the C-Labs office in ... Chris Muench , Chief Executive Officer. ...
(Date:11/18/2014)... 2014  The Secure Identity & Biometrics Association ... announce the formation of The Airport Entry and ... Identity and Biometric Entry and Exit Solutions Framework ... support from BORDERPOL, the international non-profit organization that ... expertise regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... U.S., China, Australia and Japan today reports having sequenced and ... to have a powerful genetic system that repairs genetic defects, ... more than 86 percent of the nearly 27,000 genes of ... China and elsewhere as a symbol of spiritual purity and ...
... landmark cancer study published online in Nature , ... longstanding mystery about how pancreatic tumor cells feed themselves, ... disease with few treatment options. Pancreatic cancer kills nearly ... cancer death. The life expectancy for most people diagnosed ...
... at the Institute for Systems Biology in Seattle (USA) ... the University of Luxembourg have jointly developed a revolutionary ... team of Dr. Aime Dudley from the ISB and ... the renowned scientific journal Nature Methods on ...
Cached Biology News:Scientists sequence genome of 'sacred lotus,' which likely holds anti-aging secrets 2Scientists sequence genome of 'sacred lotus,' which likely holds anti-aging secrets 3Scientists sequence genome of 'sacred lotus,' which likely holds anti-aging secrets 4Breakthrough in how pancreatic cancer cells ingest nutrients points to new drug target 2Family trees for yeast cells 2
(Date:12/24/2014)... Dallas, Texas (PRWEB) December 23, 2014 ... on methyl mercaptan such as its definition, ... also presents product specification, manufacturing process, and ... regions, technology and applications. The analysis also ... survey, marketing channels, industry development trend and ...
(Date:12/24/2014)... 2014 Vermillion, Inc. (Nasdaq:   VRML), ... announced today that investors including Oracle Investment Management, ... and several Vermillion directors have agreed to purchase ... common stock and warrants to purchase unregistered shares ... Under the terms of the ...
(Date:12/22/2014)... 2014 The Center for Professional ... technical training across the life sciences industry, has partnered ... (SCDM) to provide the organization's members with discounted classroom ... to the more than 350 sessions across 80 course ... off when registering for a public course ...
(Date:12/22/2014)... 22, 2014  ( www.competitivehealth.com ) — Competitive Health ... bill review and advocacy service, has signed an agreement ... Savings discount health services marketplace. 63% of ... than they expected to pay. As part of an ... WellCard Savings is pleased to offer medical bill review ...
Breaking Biology Technology:Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2
... - Last Sunday morning, in the free-wheeling environment of ... secrets and strategies from her forthcoming book, titled ... expects to publish next year. , ,In her seminar ... provided advice about maximizing efficiency and minimizing hurt feelings ...
... from California, to stem cell patents held by the ... and underscore the need for serious patent reform in ... patents, such as those held by WARF, needs streamlining. ... United States Patent and Trademark Office (PTO), which ...
... - Companies that increasingly depend on technology are too ... point that is not lost on Brian Brylow, managing director ... Co . , ,During the past 10 years, recruiting and ... Baird, which does not have many entry-level positions in the ...
Cached Biology Technology:BarCamp talk turns to Internet dating 2BarCamp talk turns to Internet dating 3WARF challenges show need for patent reform 2WARF challenges show need for patent reform 3WARF challenges show need for patent reform 4CIO Leadership Series: Brian Brylow, Robert W. Baird & Co. 2CIO Leadership Series: Brian Brylow, Robert W. Baird & Co. 3CIO Leadership Series: Brian Brylow, Robert W. Baird & Co. 4
These Costar 96-well, flat-bottom polystyrene EIA plates are used for EIAs, ELISAs, and other protein binding assays. Supplied as box of 100 (20 packages; 5 plates per package)....
... The standard electrophoresis hood is ... documentation systems. Placed on the ... in place and provides a ... on the lab bench. This ...
... from Paraffin embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 5 microns ... large (3-5 mm in diameter) in comparison ...
... from frozen embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 7microns and ... (3-5mm in diameter) in comparison to core ...
Biology Products: