Navigation Links
New HIV-1 replication pathway discovered by NYU College of Dentistry researchers
Date:9/18/2013

Current drug treatments for HIV work well to keep patients from developing AIDS, but no one has found a way to entirely eliminate the virus from the human body, so patients continue to require lifelong treatment to prevent them from developing AIDS.

Now, a team of researchers led by Dr. David N. Levy, Associate Professor of Basic Science and Craniofacial Biology at the New York University College of Dentistry (NYUCD), have discovered a new way that HIV-1 reproduces itself which could advance the search for new ways to combat infection.

For decades, scientists have been confident that HIV-1, the virus that causes AIDS, must insert its genetic material into a cell's DNA in order to reproduce. This process, called "integration," makes the virus a permanent part of the cell. Some of these infected cells can remain as long as the person is alive, and this is one reason why HIV+ individuals must remain on anti-HIV drugs for life.

Dr. Levy's National Institutes of Health (NIH) funded research, "HIV-1 replication without integration," published today on-line in the Journal of Virology, with lead author Dr. Benjamin Trinit, a post-doctoral fellow in Dr. Levy's laboratory, has shown HIV-1 can sometimes skip this integration step entirely.

"Although this is not the virus' main method for replicating, having this option available can help HIV survive," said Dr. Levy. "These new findings suggest one mechanism by which HIV may be surviving in the face of antiviral drugs, and suggests new avenues for research into eliminating infection."

The integration step is highly inefficient and actually fails up to 99% of the time, leaving most viruses stranded outside of the safe harbor of cell's DNA. It has been assumed that these stranded, or "unintegrated" viruses were unable to reproduce, but Dr. Levy's team has found that if the conditions are right they can generate new viruses that infect new cells.

The team also found that the unintegrated viruses can survive for many weeks in cells, allowing HIV to "hide out" in a dormant state. The ability of HIV-1 to go dormant helps it avoid elimination by antiviral drugs and immune responses.

"There is intense interest by researchers in the idea that new drugs might be developed to help to completely eliminate the virus from infected individuals," said Dr. Levy. "We think that the new replication mechanism we have found could provide a target for drugs designed to eliminate infection."

Dr Levy notes, an interesting phenomenon which other researchers have observed is that some bacteria which live in our mouths can stimulate HIV-1 to emerge from its dormant state.

"NYUCD has some terrific groups of researchers who are expert in oral flora and HIV, so we'll be quite interested in working with them to find out how oral health might influence the new replication pathway my group has discovered," added Dr. Levy.


'/>"/>

Contact: Christopher James
christopher.james@nyu.edu
212-998-6876
New York University
Source:Eurekalert

Related biology news :

1. Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies
2. DNA replication protein also has a role in mitosis, cancer
3. Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size
4. Scripps Research Institute scientists describe elusive replication machinery of flu viruses
5. Pitt team finds Achilles Heel of key HIV replication protein
6. Researchers find novel mechanism regulating replication of insulin-producing beta cells
7. CNIO researchers capture the replication of the human genome for the first time
8. New agent inhibits HCV replication in mouse models -- No resistance seen
9. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
10. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
11. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... 7, 2017 Report Highlights The ... from $8.3 billion in 2016 at a compound annual ... Report Includes - An overview of the global ... with data from 2015 and 2016, and projections of ... of the market on the basis of product type, ...
(Date:2/6/2017)... 2017 According to Acuity Market Intelligence, ... authorities to continue to embrace biometric and digital ... Automated Border Control (ABC) eGates and 1436 Automated ... than 163 ports of entry across the globe. ... a combined CAGR of 37%. APC Kiosks reached ...
(Date:2/2/2017)... Feb. 2, 2017  EyeLock LLC, a market leader ... white paper " What You Should Know About Biometrics ... ensuring user authenticity is a growing concern. In traditional ... users. However, traditional authentication schemes such as username/password suffer ... Biometric authentication offers an elegant solution to the problem ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... Feb. 17, 2017  If only one in ... a mutation-conferring resistance to chemotherapy, thousands of cancer ... has focused on finding these mutations in ever-smaller ... circulating tumor DNA in blood — to guide ... Unfortunately, however, detecting these genetic anomalies ...
(Date:2/16/2017)... ... ... EIT Digital has launched work to develop a new Smart ... about to get under way for the framework, which is designed to reduce the ... expected to be transferred eventually to other industries that also require efficient IoT and ...
(Date:2/16/2017)... MENLO PARK, Calif. and ... -- Longitude Capital, a private investment firm focused on ... today announced the promotion of Josh Richardson ... Richardson focuses on investments in biotechnology companies.  He ... and has played important roles in Longitude,s investments ...
(Date:2/16/2017)... , Feb. 16, 2017 Research ... "Synthetic Biology: Global Markets" report to their offering. ... ... (synthetic genes, biobrick parts, delivery plasmids, chassis organisms, synthetic ... and assembly, genome editing, bioinformatics and specialty media) and ...
Breaking Biology Technology: