Navigation Links
New Argonne study may shed light on protein-drug interactions
Date:1/15/2008

ecular keys. Even todays introductory biology courses rely on descriptions of protein behavior that require them to swivel and pivot very little as they interact with other biological molecules, according to Makowski. Thats a very powerful image but its not the whole story, he said. Weve learned that proteins in solution can take on an entire ensemble of slightly different structures, and that, for most proteins, this ensemble grows much larger as you go to smaller and smaller concentrations.

Makowski and his colleagues were also surprised to discover that environmental conditions strongly influence which state in this ensemble of conformations a protein prefers to enter. Most of a proteins common configurations have a functional purpose, he said, as it is not likely to twist itself into something completely irrelevant to its function.

For example, one of the five proteins examined in the study, hemoglobin, has two favored conformations: one in which it binds oxygen very readily and one in which it does not. When hemoglobin is placed in a solution that contains a great deal of available oxygen, it spends most of the time in the former state, while if oxygen is not available, it usually flips into the latter. We now know that in dilute solutions, hemoglobin actually can take on both conformations - even in the absence of oxygen, he said.

By keeping all of the environmental factors the same save for the protein concentration in the solution, Makowski and his team discovered another surprising result. Scientists had known for many years that when proteins are too concentrated, they aggregate and fall out of solution. However, biochemists previously had difficulty explaining why a similar effect also occurs in overly dilute solutions.

Proteins have hydrophobic or water-hating core regions that try to avoid touching water if at all possible. Because of this characteristic, proteins will rearrange themselves to protect these r
'/>"/>

Contact: Steve McGregor
smcgregor@anl.gov
630-252-5580
DOE/Argonne National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Argonne National Lab acquires first SiCortex SC5832
2. Argonne helps China create cleaner Beijing for 2008 Olympics
3. Sea otter study reveals striking variability in diets and feeding strategies
4. Study: weight-loss tips differ in African-American, mainstream magazines
5. Study helps explain how allergic reactions are triggered
6. Selective restraints and reduced medication could reduce nursing home falls says 4-year study
7. Study locates cholesterol genes; finds surprises about good, bad cholesterol
8. Study suggests genetic connection between short stature and arthritis
9. Radioactive understudy may aid medical imaging, drug development
10. Surprise -- cholesterol may actually pose benefits, study shows
11. Hybridization partially restores vision in cavefish, NYU study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... of Texas Health Science Center at San Antonio and ... announced the awarding of more than $750,000 in grants ... Challenge. , Launched in 2003, SALSI is a model ... academic health science center join forces for greater research ... studies, with a focus on public health issues and ...
(Date:8/19/2014)... a nearly $40,000 grant from the National Center for ... National Park Service (NPS) and U.S. Department of the ... the energy efficiency and cost effectiveness of radiant barrier ... Radiant barriers are reflective thermal insulations commonly fitted into ... the amount of heat emitted in the direction of ...
(Date:8/19/2014)... Rochelle, August 19, 2014A new ovoid structure discovered in ... clay, contains a variety of minerals, and shows evidence ... resulting melting of the permafrost and mixing of surface ... broad range of analytical studies to determine the origin ... for how this ovoid formed, point to the most ...
Breaking Biology News(10 mins):San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3Life on Mars? Implications of a newly discovered mineral-rich structure 2
... An alliance of top researchers at the University of ... Institute (SBI), advancing efforts to engineer cells and biological ... health and medicine, energy, the environment, new materials, and ... new institute aiming to create "an industrial revolution ...
... special mechanisms that delay ageing provide exceptionally good health. ... colony-forming ascidians (or sea squirts) can activate the enzyme ... also in humans who attain an advanced age. , ... individual,s body is passes on to the next generations, ...
... oximetry training video produced by Rafael Ortega, MD, the ... at Boston Medical Center (BMC) and professor of anesthesiology ... colleagues is featured in this week,s New England ... which is the fifth BMC-produced video to appear in ...
Cached Biology News:UC Berkeley launches Synthetic Biology Institute to advance research in biological engineering 2UC Berkeley launches Synthetic Biology Institute to advance research in biological engineering 3Marine organisms with eternal life can solve the riddle of aging 2Pulse oximetry training video by BMC anesthesiologist published in NEJM 2
(Date:8/18/2014)... Global HIV Infection Drug Market and ... Reportstack. The rate of HIV infection and the number of ... at a positive rate across the globe. It has been ... 2005 to 1.5 in 2013, with the rates for children ... changes in the infection rates has been the improved access ...
(Date:8/18/2014)... , Aug. 18, 2014 TNI BioTech, ... company pioneering the manufacturing and marketing of innovative therapies ... the Company is providing a second notice of TNI ... In making the announcement, Noreen Griffin , founder ... in advance for your participation in the Annual Meeting. ...
(Date:8/18/2014)... , 18. August 2014 Vier ... eine internationale klinische Studie auf, in der ... Linse soll das Sehvermögen bei allen Entfernungen ... Operation möglicherweise keine Lese- oder Gleitsichtbrille mehr ... Namen FluidVision Accommodating Intraocular Lens ...
(Date:8/16/2014)... Laser physicists have found a way to make atomic-force ... detecting forces as small as the weight of an ... The Australian National University (ANU), hinges on using laser ... degrees Celsius. , "The level of sensitivity achieved after ... weight of a large virus that is 100 billion ...
Breaking Biology Technology:Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 2Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 3Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 4Laser makes microscopes way cooler 2
... - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY ... investment in British Canadian Biosciences Corp. (BCBC), a privately ... for the treatment of a variety of conditions, including ... preferred shares of BCBC in exchange for 200,000 common ...
... The Case Western Reserve University Biomedical Engineering Department ... benefiting newborns and the aged, the critically ill and ... the future as it celebrates its 40th anniversary, Thursday, ... first universities in the nation to offer graduate and ...
... HARRISBURG, Pa., Oct. 20 PresentCare, a technology ... AdherencePlus(TM) solution, an innovative approach to assist the ... medication non-adherence. The AdherencePlus solution is comprised ... communication technology combined with unprecedented human touch. Both ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Announces Investment in Private Biotechnology Company 240 Years on the Leading Edge: Case Western Reserve University's Biomedical Engineering Department Commemorates Achievement, Looks to Future 2Medication Adherence Technology Combines with Patient Outreach Program to Yield Healthier Populations and Reduce Healthcare Costs 2Medication Adherence Technology Combines with Patient Outreach Program to Yield Healthier Populations and Reduce Healthcare Costs 3
Rabbit Anti-Human Janus Kinase 2 (JAK2 Polyclonal Antibody Family: Protein Kinase Sub-Family: TYK2/JAK Applications: ELISA, Western Blot...
MAb to HSV-2, gG-2 HSV-2 Glycoprotein G-2...
Immunogen for A300-655A was a phosphorylated synthetic peptide, which represented a portion of human RNA Polymerase II (GeneID 5430) around serine 5 of the C-terminal repeat YSPTSPS....
human Exodus-2 Research Focus: cytokine/growth factor Storage Temperature: -20C Shipping Temperature: 4C...
Biology Products: