Navigation Links
New Argonne study may shed light on protein-drug interactions
Date:1/15/2008

ecular keys. Even todays introductory biology courses rely on descriptions of protein behavior that require them to swivel and pivot very little as they interact with other biological molecules, according to Makowski. Thats a very powerful image but its not the whole story, he said. Weve learned that proteins in solution can take on an entire ensemble of slightly different structures, and that, for most proteins, this ensemble grows much larger as you go to smaller and smaller concentrations.

Makowski and his colleagues were also surprised to discover that environmental conditions strongly influence which state in this ensemble of conformations a protein prefers to enter. Most of a proteins common configurations have a functional purpose, he said, as it is not likely to twist itself into something completely irrelevant to its function.

For example, one of the five proteins examined in the study, hemoglobin, has two favored conformations: one in which it binds oxygen very readily and one in which it does not. When hemoglobin is placed in a solution that contains a great deal of available oxygen, it spends most of the time in the former state, while if oxygen is not available, it usually flips into the latter. We now know that in dilute solutions, hemoglobin actually can take on both conformations - even in the absence of oxygen, he said.

By keeping all of the environmental factors the same save for the protein concentration in the solution, Makowski and his team discovered another surprising result. Scientists had known for many years that when proteins are too concentrated, they aggregate and fall out of solution. However, biochemists previously had difficulty explaining why a similar effect also occurs in overly dilute solutions.

Proteins have hydrophobic or water-hating core regions that try to avoid touching water if at all possible. Because of this characteristic, proteins will rearrange themselves to protect these r
'/>"/>

Contact: Steve McGregor
smcgregor@anl.gov
630-252-5580
DOE/Argonne National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Argonne National Lab acquires first SiCortex SC5832
2. Argonne helps China create cleaner Beijing for 2008 Olympics
3. Sea otter study reveals striking variability in diets and feeding strategies
4. Study: weight-loss tips differ in African-American, mainstream magazines
5. Study helps explain how allergic reactions are triggered
6. Selective restraints and reduced medication could reduce nursing home falls says 4-year study
7. Study locates cholesterol genes; finds surprises about good, bad cholesterol
8. Study suggests genetic connection between short stature and arthritis
9. Radioactive understudy may aid medical imaging, drug development
10. Surprise -- cholesterol may actually pose benefits, study shows
11. Hybridization partially restores vision in cavefish, NYU study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/3/2014)... A University of Colorado Cancer Center study ... Academy of Sciences describes the activity of a ... Interleukin 37 or IL-37. It has been known to ... in the adaptive immune system: IL-37 inhibits the ability ... antigens. , "Knowing this mechanism that underlies IL-37,s effect ...
(Date:11/3/2014)... low birth weight and preterm birth are linked to ... Findings published in the American College of Rheumatology (ACR) ... low birth weight and pre-term babies were not at ... adults. , According to the ACR, 27 million ... clinical OA. Symptoms of OA range from mild to ...
(Date:11/2/2014)... ORLEANS, LA (2 November 2014)—In support of a bold ... Bill & Melinda Gates Foundation today announced an award ... Malaria Vaccine Initiative (MVI) in building new vaccines that ... help realize the "accelerating to zero" agenda. Such vaccines ... what could be called an "immunological bed net." ...
Breaking Biology News(10 mins):PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4
... waste from nearby manufacturing plants flowed into the waters ... The harbor, which is contaminated with polychlorinated biphenyls (PCBs) ... Superfund cleanup sites. It,s also the site of ... Institution (WHOI) and their colleagues have been working to ...
... The rapid conversion of natural lands to cement-dominated urban centers ... new study involving 147 cities worldwide, surprisingly high numbers of ... environments to the tune of hundreds of bird species ... Contrary to conventional wisdom that cities are a wasteland for ...
... bags, an abundant source of litter on land and ... and other useful petroleum products, researchers report. The ... results in transportation fuels diesel, for example ... biodiesels. Other products, such as natural gas, naphtha (a ...
Cached Biology News:Solving an evolutionary puzzle 2Solving an evolutionary puzzle 3Solving an evolutionary puzzle 4Cities support more native biodiversity than previously thought 2Cities support more native biodiversity than previously thought 3Plastic shopping bags make a fine diesel fuel, researchers report 2
(Date:11/21/2014)... , Todd Martensen ... Mariano Rodríguez es elegid vicepresidente senior de desarrollo empresarial ... en marcha para comenzar de forma rápida la comercialización de ... aprobación en Europa   , KLOX ... los siguientes nombramientos: Todd Martensen ha ...
(Date:11/21/2014)... Diego, CA (PRWEB) November 20, 2014 ... extended their Sartorius Entris Balance promotion . The ... customers seeking a durable, high accuracy, and easy-to-maintain balance ... made in Germany. It was designed to help customer’s ... affordable and a balance that is very durable. Sartorius ...
(Date:11/21/2014)... The report, "Synthetic Biology Market ... kits), Technology (Bioinformatics, Nanotechnology, Gene Synthesis, Cloning ... - Global Forecast to 2018", analyses and ... and challenges. , Browse 99 market data ... pages and in-depth TOC of the global ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 Why did ... makes Albert Einstein so instantly recognizable? Why have they ... mathematician, astronomer and author Hilton Ratcliffe seeks out the ... nothing at all to do with science. In " ... Publishing , November 21, 2014), Ratcliffe puts it plainly: ...
Breaking Biology Technology:KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... Type III von Willebrand Disease, a serious, hereditary ... bleeding disorder, found in ... Behring today,announced that Iran,s Ministry of Health and Medical Education ... on an exclusive,basis throughout Iran, beginning immediately. Haemate P is ...
... Path for ... New Treatments, WILMINGTON, Del. and ... ) today announced,that they will collaborate to help advance understanding of Alzheimer,s,disease ... cutting-edge brain imaging methods., The new alliance will focus on the ...
... TUSTIN, Calif., Dec. 19 AMDL, Inc., (Amex:,ADL), ... a,developer, manufacturer, and marketer of pharmaceutical, nutraceutical,diagnostic, consumer ... open,its first large-scale JPGreen Health and Personal Care ... by Jade to be converted,into a flagship JPGreen ...
Cached Biology Technology:CSL Behring Expands Into Middle East Market with Haemate(R) P 2CSL Behring Expands Into Middle East Market with Haemate(R) P 3AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 2AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 3AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 4AMDL's First Full Service JPGreen Health and Personal Care Center Set to Open in Hangzhou, China 2
Mouse monoclonal [4A2.2] to SLC6A4 ( Abpromise for all tested applications). entrezGeneID: 6532 SwissProtID: P31645...
... The 2/3D Waver Shaker combines shaking and ... with a 330 x 330 mm stainless steel ... top incubator and cold room operation. The platform ... degree for a vigorous with action and rotation ...
Anti-DNA Polymerase a, Human Description: 50 l Research Focus: cancer & cell proliferation Storage: 4C Shipping Temperature: 4C...
... The Experion HighSens analysis kit for 25 ... to perform high-sensitivity RNA analysis (at picogram ... This kit includes 25 RNA HighSens microfluidic ... 2 x 20 microliters RNA HighSens stain, ...
Biology Products: