Navigation Links
New American Chemical Society podcast: Genetically-engineered spider silk for gene therapy
Date:11/16/2011

WASHINGTON, Nov. 16, 2011 A new episode in the American Chemical Society's (ACS) award-winning "Global Challenges/Chemistry Solutions" podcast series spins a real-life tale in which spider silk shows promise for overcoming a major barrier to the use of gene therapy in everyday medicine.

The new installment from the world's largest scientific society explains in non-technical language that gene therapy involves the use of beneficial genes to prevent or treat disease. It requires safe and efficient carriers or "vectors." Those carriers are the counterparts to pills and capsules, transporting therapeutic genes into cells in the body. Safety and other concerns surround the experimental use of viruses to insert genes. The lack of good gene delivery systems is a main reason why there are no FDA-approved gene therapies, despite almost 1,500 clinical trials since 1989. The new study focused on one promising prospect, silk proteins, which are biocompatible and have been used in everyday medicine and medical research for decades.

David Kaplan, Ph.D., notes in the podcast that he modified spider silk proteins so that they attach to diseased cells and not to healthy cells. He also engineered the spider silk to be able to carry a gene that codes for a protein that makes fireflies glow so that they could provide a visual signal that's seen with specialized equipment that the gene has reached its intended cellular target.

In lab studies using mice containing human breast cancer cells, the spider-silk proteins attached to the cancer cells and injected the DNA material into the cells without harming the mice. Kaplan says that the results suggest that genetically-engineered spider-silk proteins represent a versatile, very highly tailorable and useful new platform polymer for nonviral gene delivery.

The new podcast is available without charge at iTunes and from www.acs.org/globalchallenges.

Global Challenges/Chemistry Solutions is a series of podcasts describing some of the 21st Century's most daunting problems, and how cutting-edge research in chemistry matters in the quest for solutions. Global Challenges is the centerpiece in an alliance on sustainability between ACS and the Royal Society of Chemistry. Global Challenges is a sweeping panorama of global challenges that includes dilemmas such as providing a hungry, thirsty world with ample supplies of safe food and clean water; developing alternatives to petroleum to fuel society; preserving the environment and assuring a sustainable future for our children; and improving human health. During the 2011 global celebration of the International Year of Chemistry (IYC), Global Challenges/Chemistry Solutions also is focusing on the main themes of IYC health, environment, energy, and materials.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Related biology news :

1. Rusk experts present at American Association of Physical Medicine and Rehabilitation meeting
2. Gladstone founder receives American Heart Association Distinguished Scientist Award
3. Bonnie Bassler chosen North American Laureate for L’OREAL-UNESCO award
4. NYU Langone experts present at American College of Rheumatology 2011 Annual Meeting
5. Unisys Security Index Shows Americans Will Take Action against Organizations That Compromise Their Personal Data
6. New research on GI health unveiled at American College of Gastroenterologys 2011 Meeting
7. ONR strengthens partnerships at Hispanic-American conference
8. 21 Fellows inducted into American College of Medical Informatics
9. American Society of Plant Biologists supports science outreach by grad students and postdocs
10. Evolutionary biologist inducted into American Academy of Arts and Sciences
11. American Life Sciences Innovation Council Launches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: