Navigation Links
New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis
Date:11/8/2007

The innovative new rheumatoid arthritis drug Actemra (tocilizumab) has been shown to significantly improve the signs and symptoms of rheumatoid arthritis (RA) in patients who failed to achieve an adequate response to traditional disease modifying agents (DMARDs). Exciting new data from the TOWARD1 study, being presented as a late breaker, at the American College of Rheumatology (ACR) Annual Scientific Meeting in Boston, November 6-11, reinforce the benefit of tackling RA through the inhibition of the IL-6 pathway.

In the TOWARD trial, 61% of patients in the Actemra plus DMARD group achieved a 20% reduction in RA symptoms (ACR202 response) compared with only 25% of patients in the control group. Around one in three patients achieved clinical remission in the Actemra group, as assessed using DAS28 <2.63 .These results are consistent with the results of another Actemra trial, the OPTION4 study, which were previously reported and which will be the subject of further presentations at ACR. The OPTION study showed that 59% of patients in the Actemra treatment arm experienced a 20% reduction in RA symptoms (ACR20 response) versus only 27% of patients in the control group.

"We are very encouraged by the findings of this new TOWARD data which suggest that Actemra plus DMARDs demonstrates significant improvement in RA symptoms compared with DMARDs alone," said Mark C. Genovese, M.D., lead study investigator of the TOWARD trial and associate Professor of Medicine at Stanford University School of Medicine. "These data further establish the efficacy of Actemra and confirm that inhibiting the interleukin-6 (IL-6) receptor is a novel method of reducing RA symptoms."

"These results show that remission rates achieved with Actemra compare favourably with current RA therapies indicating the medicine's potential to become a very effective new treatment option," said Dr. Urs Schleuniger, Head of Inflammatory Diseases, Roche. "Findings from the TOWA
'/>"/>

Contact: Nicole Moores
nicole_moores@uk.cohnwolfe.com
44-020-733-15337
Cohn & Wolfe, London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Clones on task serve greater good, evolutionary study shows
3. Study shows link between alcohol consumption and hiv disease progression
4. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
5. New study shows greenback cutthroat trout involved in recovery effort misidentified
6. DNA analysis shows true dispersal of protozoa
7. New genetic research into nicotine addiction shows promise for personalized treatment
8. International team shows mercury concentrations in fish respond quickly to increased deposition
9. New study shows fish respond quickly to changes in mercury deposition
10. Amazon forest shows unexpected resiliency during drought
11. New study shows fish respond quickly to changes in mercury deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Despite a significant reduction in smog-producing toxins in ... , A new study shows that while the ... of the toxins that contribute to smog, the ... ozone air pollution., Smog, which can cause or ... chronic bronchitis, is produced by a set of ...
(Date:8/21/2014)... ignore, but they are the ultimate source of all ... increasingly dependent on algae, too, to suck up climate-warming ... the bottom of the ocean. Now, by using a ... evidence showing that viruses infecting those algae are driving ... all else stays essentially the same, and this has ...
(Date:8/21/2014)... Nine researchers from Beth Israel Deaconess Medical Center (BIDMC ... World,s Most Influential Scientific Minds 2014," a comprehensive ... a web resource for science metrics and research performance ... the most influential "are performing and publishing work that ... their science," according to a Thomson Reuters statement. Researchers ...
Breaking Biology News(10 mins):Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2Viruses take down massive algal blooms, with big implications for climate 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... LA JOLLAThe Salk Institute for Biological Studies will join ... in Stem Cell Genomics, created through a $40 million ... for Regenerative Medicine. The center will bring together ... focus on bridging the fields of genomics the ...
... joining you just moments after you poured that first ... to conduct a finely-choreographed search, one that,s been described ... of Washington.The search mission is another example of fruit ... their brains having 100,000 neurons compared to house flies ...
... a small peninsula of 11,500 km2 within the Arabian ... during the last decades, thus putting a strong pressure ... towards sustainable development has triggered a variety of studies ... project has confirmed the occurrence of 21 lizard species, ...
Cached Biology News:Salk Institute and Stanford University to lead new $40 million stem cell genomics center 2Salk Institute and Stanford University to lead new $40 million stem cell genomics center 3Fruit flies -- fermented-fruit connoisseurs -- are relentless party crashers 2Fruit flies -- fermented-fruit connoisseurs -- are relentless party crashers 3Where do lizards in Qatar live? First distribution maps for the state 2
(Date:8/21/2014)... A Finnish-Swedish research group at the Institute for ... Karolinska institutet, Stockholm, has developed a novel "man ... infection. This innovative diagnostic aid was described in ... August. The method is based on computer vision ... systems combined with visualization of only the diagnostically ...
(Date:8/21/2014)... 2014 2014 Deep Research ... a professional and in-depth research report on ... basic Seaweed Fertilizer information, including Seaweed Fertilizer ... as well as industry overview. This research ... market as well as global industry analysis ...
(Date:8/21/2014)... 2014 His Majesty Willem-Alexander, King of ... Court of His Majesty Willem-Alexander, King of the Netherlands, ... Opening of POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol ... The King will take part in the Grand Opening ... 11 a.m.-12:20 p.m. and tour the plant. POET-DSM is ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 The College ... first private college in the Mid-Hudson Region to be ... now begin accepting applications from qualified “high-technology” businesses that ... are very pleased to have been selected for the ... Cuomo’s transformative initiative to stimulate economic development in New ...
Breaking Biology Technology:A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3
... DALLAS, Texas , April ... report, ,global oncology biomarker market, published by,MarketsandMarkets ( http://www.marketsandmarkets.com ... from $4.1 billion in 2009 to ... from 2009 to 2014. The Global Oncology,Biomarkers Market report ...
... is to be conducted at Glenfield Hospital Leicester thanks ... Hospitals of Leicester. Dr Andr Ng, Senior Lecturer ... Consultant Cardiologist and Electrophysiologist, Glenfield Hospital, University Hospitals of ... carry out the operation remotely on patients using this ...
... ... full-custom SoC technology without the cost and leadtime on display at ESC Silicon Valley, ... ... embedded motion control systems, today announced its partnership with Actel Corporation (NASDAQ: ACTL) for ...
Cached Biology Technology:MarketsandMarkets: Global Oncology Biomarkers Market Worth US$9.5 Billion by 2014 2MarketsandMarkets: Global Oncology Biomarkers Market Worth US$9.5 Billion by 2014 3MarketsandMarkets: Global Oncology Biomarkers Market Worth US$9.5 Billion by 2014 4World first remote heart operation to be carried out in Leicester using robotic arm 2World first remote heart operation to be carried out in Leicester using robotic arm 3TRINAMIC Teams with Actel's SmartFusion&#8482; Intelligent Mixed Signal FPGAs for Motion Control 2
... Galaxy LIMS, Sophisticated Bioinformatics , Proprietary primer ... offer individual sample sequencing of PCR products, ... or double strand publication quality. Primer ... interest is 1.3 to 7 kilobytes long. ...
Shotgun library construction and high-throughput DNA sequencing of microbial genomes, BACs, adenoviruses, phosmids and cosmids. LIMS tracking utilizing Geospiza's Finch system....
...
... Affinity Life Sciences can provide custom microplate coating using ... washes a variety of plate formats. We can also accommodate ... volume range of 0.5-320 L):, , ... 96 well microplate, ...
Biology Products: