Navigation Links
New 3-D tumor model
Date:6/8/2011

College Park, Md. (June 08, 2011) A team of scientists has developed a way to coax tumor cells in the lab to grow into 3-D spheres. Their discovery takes advantage of an earlier technique of producing spherical cavities in a common polymer and promises more accurate tests of new cancer therapies.

As team leader Michael R. King, Ph.D., of Cornell University explains, "Sometimes engineering research tends to be a case of a hammer looking for a nail. We knew our previous discovery was new and it was cool. And now we know it's useful."

Three years ago, the team -- in collaboration with Lisa DeLouise, Ph.D., MPD, of Rochester, N.Y. -- perfected a low-cost, easy fabrication technique to make spherical cavities in PDMS (polydimethylsiloxane), a widely used silicon organic polymer. More recently, the Cornell team discovered that these cavities could be used as a scaffolding to grow numerous tumor spheroids, which could serve as realistic models for cancer cells. The Cornell team's work appears in the current issue of Biomicrofluidics, a publication of the American Institute of Physics.

The three-dimensional spheroids hold the potential to speed cancer drug discovery by providing a realistic and easily accessible substrate on which to test drugs. Their 3-D nature is an asset because in the body, tumor cells grow in 3-Dyet most laboratory studies of cancer have been done in 2-D, with a single layer of cancer cells grown on the bottom of a petri dish. Too often a promising 2-D drug candidate fails when it enters the 3-D stage of animal testing. The new 3-D tumor spheroids may help eliminate that problem. They also offer a realistic tumor oxygen environment that cues the blood vessel growth that nourishes tumorsan appealing target for anti-cancer drug design.

"Basically, any laboratory that works with cells could adopt our new spherical microcavity system to do their own 3-D experiments or drug screening on hundreds or even thousands of little tumor spheroids," said King.


'/>"/>

Contact: Charles E. Blue
cblue@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related biology news :

1. Childrens National researchers develop novel anti-tumor vaccine
2. A link between mitochondria and tumor formation in stem cells
3. Design of a compound that stabilizes the main natural suppressor of tumors
4. Researchers identify Achilles heel of common childhood tumor
5. Purple tomatoes: The richness of antioxidants against tumors
6. Jefferson Department of Surgery announces new pancreas tumor registry
7. Two new compounds show promise for eliminating breast cancer tumors
8. 2 new compounds show promise for eliminating breast cancer tumors
9. Novel technique for fluorescence tomography of tumors in living animals
10. Researchers identify new anti-tumor gene
11. UC Davis researchers find molecule that targets brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... Paramus, New Jersey (PRWEB) , ... September 21, ... ... for highly-regulated pharmaceutical and clinical research sector professionals, has announced the addition of ... CFR Part 11 training - Compliance with Regulation 21 CFR Part 11 ...
(Date:9/20/2017)... ... 20, 2017 , ... Cybrexa Therapeutics , a start-up ... role of chief scientific officer. In this role, Dr. Paralkar will lead the ... CEO, Per Hellsund. , “I was impressed with Cybrexa’s revolutionary technology and excellent ...
(Date:9/20/2017)... ... September 20, 2017 , ... From industry leaders, sports stars, ... standard medicine failed. Many of these people had lost all hope. Their ... Free Download (pdf) , “Neil takes readers on a riveting journey ...
(Date:9/19/2017)... Philadelphia, PA (PRWEB) , ... September 19, 2017 ... ... are joining Philadelphia’s largest group of funded early-stage tech companies. “Grit” author Angela ... anchor tenant. Also joining the ic@3401 community is Cooley, an international law firm ...
Breaking Biology Technology: