Navigation Links
New 3-D test method for biomaterials 'flat out' faster
Date:4/29/2008

A novel, three-dimensional (3-D) screening method for analyzing interactions between cells and new biomaterials could cut initial search times by more than half, researchers from the National Institute of Standards and Technology (NIST) and Rutgers University report in the new issue of Advanced Materials.* The technique, an advance over flat, two-dimensional screening methods, enables rapid assessment of the biocompatibility and other properties of materials designed for repairingor even rebuildingdamaged tissues and organs.

In what may be a first, the team demonstrated how to screen cellmaterial interactions in a biologically representative, but systematically altered, 3-D environment. The pivotal step in the experiment was the collaborators success in making so-called libraries of miniature porous scaffolds that are bone-like in structure but vary incrementally in chemical composition. Knowing how changes in scaffold ingredients influence cell responses, researchers can devise strategies for developing biomaterials optimized for particular therapies and treatments.

Until now, attempts to accelerate screening of candidate biomaterials have used flat films and surfaces. (See, for example, Designer Gradients Speed Surface Science Experiments, Tech Beat June 8, 2006. http://www.nist.gov/public_affairs/techbeat/tb2006_0608.htm#designer ) Along with other shortcomings, these two-dimensional substrates are neither consistent with cells normal 3-D environment inside the body nor with the most common intended use of biomaterials: creating scaffolds to encourage the growth of cells into functional 3-D tissues and organs.

Cells are very sensitive to the texture, shapes, and other three-dimensional features of their local environment inside the body, explains NIST biomaterial scientist Carl Simon. The large difference in structure between 2-D films and 3-D scaffolds should be considered when screening new materials.

On a series
'/>"/>

Contact: Mark Bello
mark.bello@nist.gov
301-975-3776
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research identifies first method for testing, assessing drug treatments for Chagas disease
2. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
3. Queens develops safe green decontamination method
4. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
5. A new method to identify mutated genes in human diseases
6. New method to estimate sea ice thickness
7. Powerful yet reliable proteomics techniques are the focus of a new methods book
8. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
9. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
10. New method developed to identify genetic determinants of Alzheimers disease
11. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New 3-D test method for biomaterials 'flat out' faster
(Date:1/22/2015)... 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is pleased ... State of Washington,s Department of Licensing, ... and central issuance system for driver,s licenses and identification cards ... planning and development will start in January 2015, with enrollment ...
(Date:1/22/2015)... , Jan. 16, 2015  A man-made form of insulin ... other mental capabilities in adults with mild cognitive impairment ... led by researchers at Wake Forest Baptist Medical Center. ... with amnesic mild cognitive impairment (MCI) or mild to ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Global Wearable Technologies Market ... Share, Overview, Trends and Forecast 2014-2020" report ... Technologies are smart devices that can be worn ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... In India most people who are HIV positive don,t ... available. It would therefore meet international standards of cost-effectiveness ... every person in the billion-plus population every five years according ... One . The findings are based on a careful ...
... of Biology provides the basis for an argument against ... thermodynamics of microbial growth. Microbial growth is a biological ... operating in accord with the Gibbs free energy equation, developed ... first to be measured by direct calorimetry, in 1856. However, ...
... supposedly rare mutations in the mitochondria, the ,power plants, ... more than 7% of patients with a mitochondrial disease ... data emphasise the need for comprehensive analysis of all ... a mitochondrial disease, and this should include children, a ...
Cached Biology News:Cost-effective: Universal HIV testing in India 2Cost-effective: Universal HIV testing in India 3Cost-effective: Universal HIV testing in India 4When calculating cell-growth thermodynamics, reconsider using the Gibbs free energy equation 2Rare mitochondrial mutations -- maybe not so rare? 2
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)... 22, 2015   Cypher Genomics, Inc., the ... SQNM ), the leading molecular diagnostics ... generation noninvasive prenatal tests (NIPT). Through this agreement, ... Mantis™, to advance analysis of clinically-relevant fetal sub-chromosomal ...
(Date:1/22/2015)... N.J. , Jan. 22, 2015  Derma Sciences, ... regeneration company focused on advanced wound care, announces ... placental tissues, have been added to the Premier, ... increases the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... in critical areas, announced the closing of an underwritten public ... purchase up to an aggregate 3,500,000 shares of common stock, ... per warrant.  The warrants have a per share exercise price ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... A generally accepted 44-year-old assumption about how certain kinds of ... to be incorrect by a team of scientists led by ... Penn State University and a research professor in the Department ... which will be published in the journal Science ...
... Notre Dame have demonstrated a novel DNA detection method ... Carol Tanner and Steven Ruggiero led the team in ... spectroscopy (LTS). LTS is capable of rapidly determining the ... In a new paper appearing in the international, peer-reviewed, ...
... 2011  Today BioSpace , the leading life sciences employment ... , celebrating its 13th edition. (Logo: ... across Massachusetts. Each company,s brand is added to an electronic ... as well as at industry events and career fairs. The ...
Cached Biology Technology:Decades-old conclusion about energy-making pathway of cyanobacteria is corrected 2Decades-old conclusion about energy-making pathway of cyanobacteria is corrected 3Notre Dame researchers demonstrate new DNA detection technique 2BioSpace Spotlights Leading Life Science Community 2
RABBIT ANTI RAT AQUAPORIN 5...
... Automatic High Sensitivity Laboratory Osmometer for both 0.2 and 2.0 mL samples for ... and record keeping. Bar code reading capability with optional scanner. RS-232 port. ... ... ...
MAb to Hu-IFN-Gamma RC2 (CD118), NON-Neutralizing, Clone MMHGR-2 Binds to but does not neutralize human interferon gamma receptor...
Recombinant Rat CINC-2 alpha, CF...
Biology Products: