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New, 'designer' fiber may help address fiber intolerance and ease IBS symptoms
Date:1/16/2014

fatty acid, butyrate in order to promote gut health and to have a so-called "prebiotic effect" for it to be a supplemental treatment for IBS. IBS is the most common reason for a gastroenterologist specialist consultation. Currently, there are no universally effective treatment options for IBS.

The fiber is a targeted, controlled-release fiber that travels through the large intestine to be fermented by bacteria in the entire colon including the descending [distal] colon where colon cancer, diverticulitis, ulcerative colitis and irritability commonly occur. The fiber can be designed to target different locations. This enables the bacteria in the large intestine to receive important nutrients from the fiber, which promotes overall gut health.

"We worked closely with Purdue University food scientist Bruce Hamaker, PhD, to develop well-tolerated fiber with targeted delivery to the entire colon that could promote "gut health" and possibly prevent and treat colonic diseases where changes in the gut play a key role," said Keshavarzian.

A $2.5 million federal grant to develop the fiber invented at Rush University Medical Center and Purdue University's College of Agriculture was given to Nutrabiotix LLC, based in the Purdue Research Park, which is commercializing the patented designer fiber created by Hamaker, and Keshavarzian.

The two-year SBIR Phase II grant of $2.5 million is from the National Institute of Diabetes and Digestive and Kidney Diseases, which is part of the National Institutes of Health (NIH) and the U.S. Department of Health and Human Services. This two-year clinical trial will begin in January 2014 and will be completed in 2016. Hamaker is director of the Roy L. Whistler Center of Carbohydrate Research and holds the Roy L. Whistler Chair in Carbohydrate Science in Purdue's Department of Food Science.

Nutrabiotix had received an SBIR Phase I grant from the NIH worth $250,000 in 2010. The State of Indiana's 2
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Contact: Nancy DiFiore
nancy_difiore@rush.edu
312-942-5159
Rush University Medical Center
Source:Eurekalert

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