Navigation Links
Neutron studies of HIV inhibitors reveal new areas for improvement
Date:8/14/2013

ctions with the main-chain atoms were already considered strong. However, this has been shown not to be the case, creating a new avenue for the development of HIV pharmaceuticals much less affected by virus evolution and resistance.

Quotes

Dr Matthew Blakeley, Institut Laue-Langevin said: "This study perfectly illustrates the benefits of neutrons in drug design due to their unique sensitivity to hydrogen atoms. Until recently high-resolution neutron studies of large biological systems were restricted due to the size of crystals that needed to be grown and the length of time it took for the results to be collected. However, significant technical developments, led by pioneering work here at the ILL, have greatly extended the range of experiments that can be performed providing the pharma industry with a powerful new tool to improve the performance of their products."

Andrey Kovalevsky, Oak Ridge National Laboratory said: "X-ray crystallography has been playing a crucial role in the structure-guided drug design for over two decades. It provides us with a picture of how a drug molecule binds to its macromolecular target, which is usually achieved through non-covalent interactions between these two molecules. The majority of such weak intermolecular interactions involve hydrogen atoms that normally remain invisible in X-ray structures. If one knows where hydrogen atoms are located it gives a researcher a much better idea about the nature and strength of the interactions. By applying neutron crystallography we have effectively increased the clarity of this picture, because hydrogen atoms become visible in the neutron structures. It is fair to say that by using neutrons we are now able to see every atom in a protein/drug complex, all the way to the smallest atom in nature. We are confident that by combining the two crystallographic techniques it will be possible to significantly improve the method of structure-guided drug design, which will
'/>"/>

Contact: Jenny Chapman
jenny@proofcommunication.com
Georgia State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Neutrons help explain why antibiotics prescribed for chemotherapy cause kidney failure
2. ORNLs newly licensed neutron detector will advance human disease research
3. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
4. Family studies suggest rare genetic mutations team up to cause schizophrenia
5. UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies
6. Single-cell transfection tool enables added control for biological studies
7. Studies support population-based efforts to lower excessive dietary sodium intakes
8. New scientific studies reveal Midwestern frogs decline, mammal populations altered by invasive plant
9. 3 new studies reveal added fibers impact on various health indices
10. AACR news: Studies show increasing evidence that androgen drives breast cancer
11. Deadly effects of certain kinds of household air pollution lead to call for biomarker studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
(Date:7/7/2015)... Research and Markets ... the "Capacitive Fingerprint Sensors Patent Landscape" ... date, fingerprint sensing technology is the most reliable ... well developed. This patent landscape focuses on fingerprint ... domain of capacitive fingerprint sensors is closely linked ...
(Date:7/2/2015)... July 2, 2015 Fingerprint Cards has ... FPC1145 and FPC1155 from the distributor World Peace Industrial Group ... distributors in Asia . Deliveries are planned ... will be used by smartphone manufacturers in Asia ... in the communicated revenue guidance of approximately 2,200 MSEK for ...
Breaking Biology News(10 mins):Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... available in Spanish . A newly identified ... could mean improved traps for monitoring and controlling the tree-killing ... entomologist Allard Coss and his colleagues. Coss has been ... multidisciplinary team of scientists from USDA,s Agricultural Research Service (ARS), ...
... 2011 Moms-to-be long have been told by their doctors ... is good for both mother and child. When it was ... fetus, heart control, many pregnant women took heed and hit ... classes; others found new ways to incorporate low-impact aerobic activities ...
... WASHINGTON, April 7, 2011 Timing is everything. That,s especially ... by the pancreas to break down food. When the timing ... the gut, where they get to work releasing and distributing ... wrong and the enzymes are activated too soon, they break ...
Cached Biology News:Scientists exploit ash tree pest's chemical communication 2Physically active moms-to-be give babies a head start on heart health 2Physically active moms-to-be give babies a head start on heart health 3Findings may help keep pancreatic disease off the menu 2
(Date:8/4/2015)... Mass. , Aug. 4, 2015  Blueprint Medicines ... developing highly selective kinase drugs for genomically defined diseases, ... officer, will present a company overview at the 2015 ... at 1:20 p.m. EDT. A live webcast ... Investors section of the Blueprint Medicines website at ...
(Date:8/3/2015)... Aug. 3, 2015  Halozyme Therapeutics, Inc. (NASDAQ: ... for the second quarter 2015 on Monday, August 10, ... Helen Torley , president and chief executive officer, will ... will release financial results for the second quarter 2015. ... the "Investors" section of Halozyme,s corporate website and a ...
(Date:8/3/2015)... , Aug. 3, 2015  Merck KGaA, Darmstadt, ... and top-quality high-tech products in the healthcare, life science ... US-based company Nano-C, their development and launch of promising ... photovoltaics (OPV). Merck KGaA, Darmstadt, Germany ... growing OPV sector. Novel derivatives: highly stable, ...
(Date:8/3/2015)... , August 3, 2015 ... Study on 3D Cell Culture: Asia ... Persistence Market Research, the global 3D cell culture market was valued ... to expand at a CAGR of 29.1% to account ... Full Report with TOC:  http://www.persistencemarketresearch.com/market-research/3d-cell-cultures-market.asp 3D ...
Breaking Biology Technology:Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4
... 6, 2011 Morphotek®, Inc., a subsidiary of Eisai Inc., ... Award from Cancer Care , a national support services ... Cancer Care ,s educational programs for people facing lung and ... help patients and their families become aware of options available ...
... 6, 2011 Health Care Compliance Strategies, Inc. ... of Detroit, MI., has selected the COI-SMART system ... conflict of interest disclosure process. COI-SMART will handle ... employees. (Logo: http://photos.prnewswire.com/prnh/20061010/NYTU194LOGO) "Henry ...
... Corporation (NASDAQ: LIFE ) announced today it will ... 26, 2011, after market close. The company will also hold ... to discuss operating results, as well as future expectations. ... webcast can be accessed through the investor relations page of ...
Cached Biology Technology:Morphotek®, Inc. Receives Beacon Award From CancerCare 2Morphotek®, Inc. Receives Beacon Award From CancerCare 3Conflict of Interest Management System Selected by Henry Ford Health System 2Life Technologies Sets 1st Quarter 2011 Earnings Release Date for Tuesday, April 26, 2011 2
The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver une...
... Kit is based on quantification of the ... and free orthophosphate. The rapid color formation ... on a spectrophotometer (600-660 nm) or on ... kits have been optimized to offer superior ...
The Odyssey Infrared Imaging System is a complete family of products that includes the Odyssey Imager, IRDye labeling reagents and Odyssey software for scan control and data analysis....
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selecitivty and potential CNS-Side Effect liabilities of compo...
Biology Products: