Navigation Links
Neutron studies of HIV inhibitors reveal new areas for improvement
Date:8/14/2013

ctions with the main-chain atoms were already considered strong. However, this has been shown not to be the case, creating a new avenue for the development of HIV pharmaceuticals much less affected by virus evolution and resistance.

Quotes

Dr Matthew Blakeley, Institut Laue-Langevin said: "This study perfectly illustrates the benefits of neutrons in drug design due to their unique sensitivity to hydrogen atoms. Until recently high-resolution neutron studies of large biological systems were restricted due to the size of crystals that needed to be grown and the length of time it took for the results to be collected. However, significant technical developments, led by pioneering work here at the ILL, have greatly extended the range of experiments that can be performed providing the pharma industry with a powerful new tool to improve the performance of their products."

Andrey Kovalevsky, Oak Ridge National Laboratory said: "X-ray crystallography has been playing a crucial role in the structure-guided drug design for over two decades. It provides us with a picture of how a drug molecule binds to its macromolecular target, which is usually achieved through non-covalent interactions between these two molecules. The majority of such weak intermolecular interactions involve hydrogen atoms that normally remain invisible in X-ray structures. If one knows where hydrogen atoms are located it gives a researcher a much better idea about the nature and strength of the interactions. By applying neutron crystallography we have effectively increased the clarity of this picture, because hydrogen atoms become visible in the neutron structures. It is fair to say that by using neutrons we are now able to see every atom in a protein/drug complex, all the way to the smallest atom in nature. We are confident that by combining the two crystallographic techniques it will be possible to significantly improve the method of structure-guided drug design, which will
'/>"/>

Contact: Jenny Chapman
jenny@proofcommunication.com
Georgia State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Neutrons help explain why antibiotics prescribed for chemotherapy cause kidney failure
2. ORNLs newly licensed neutron detector will advance human disease research
3. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
4. Family studies suggest rare genetic mutations team up to cause schizophrenia
5. UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies
6. Single-cell transfection tool enables added control for biological studies
7. Studies support population-based efforts to lower excessive dietary sodium intakes
8. New scientific studies reveal Midwestern frogs decline, mammal populations altered by invasive plant
9. 3 new studies reveal added fibers impact on various health indices
10. AACR news: Studies show increasing evidence that androgen drives breast cancer
11. Deadly effects of certain kinds of household air pollution lead to call for biomarker studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... , August 31, 2015 Growing ... technology in government digitization projects to drive India ... recently published TechSci Research report, " India Biometrics Market Forecast ... is projected to grow at a CAGR of ... is anticipated on account of extensive use of biometric technology ...
(Date:8/31/2015)... , Aug. 31, 2015 Research and ... the "Saudi Arabia Biomedical Sensors Market - Growth, ... The Saudi Arabia Biomedical Sensors market ... CAGR of 3.64% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
(Date:8/28/2015)... 28, 2015 According to a ... by Assessment Type (Pen & Paper Based, Hosted, Biometrics), ... Learning, Academic Research), Vertical and Region - Global Forecast ... Market to grow from USD 2.4 Billion in 2015 ... Annual Growth Rate (CAGR) of 25.6% from 2015 to ...
Breaking Biology News(10 mins):India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 2India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 3Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4
... Building aircraft wings with a special aluminium fibre ... The application of this technology, partly developed at ... savings. The unusual qualities of this special material ... can make a significant contribution to the development ...
... 26 2007 -- Consuming large amounts of caffeine while ... in the United States, could potentially cause liver damage, ... Oct. 15 print issue of ACS Chemical Research in ... not only from drinking caffeinated beverages while taking the ...
... and pressures influence nearly every part of children,s daily ... special supplement of the American Journal of Preventative Medicine. ... the University of Michigan, reveal that, in most middle ... drink bottling companies give students easy access to sugary ...
Cached Biology News:New Delft material concept for aircraft wings could save billions 2Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage 2Studies: Children obese due to a host of unhealthy pressures 2Studies: Children obese due to a host of unhealthy pressures 3Studies: Children obese due to a host of unhealthy pressures 4
(Date:8/28/2015)... ... 28, 2015 , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the ... service. Images such as the Fonz in a lab coat and Large Marge have ... humdrum spectroscopy field. , FireflySci is proud to be the only cuvette manufacturer ...
(Date:8/27/2015)... ... , ... Capital Edge Consulting , a nationwide consulting firm that specializes ... ranking as one of the top 5000 companies listed on the 2015 Inc. ... , “It is truly an honor to be recognized as one of America’s fastest ...
(Date:8/27/2015)... Aug. 27, 2015 /PRNewswire/ - Portage Biotech Inc. ... and Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced ... I study of BHV-0223, a glutamate modulating agent. ... BHV-0223 and recently obtained clearance from the U.S. ... human testing. Portage holds 54% equity interest in ...
(Date:8/27/2015)... Calif. , Aug. 27, 2015  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, today announced that ... conferences in the month of September.  ... present at Rodman & Renshaw,s 17th Annual Global Investment ... PT at the St. Regis Hotel in ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2
... The Sloan Consortium, a professional leadership organization ... named Polytechnic Institute of New York University (NYU-Poly) ... among its 2011 Sloan-C Fellows. This is the ... Ubell, a noted author on the subject. ...
... Inc. and Biomatrica have begun a ... is becoming increasingly important in cancer research and in ... The two organizations will focus on developing ... collected by pathologists in the clinic. Preserving nucleic acids, ...
... which, thanks to a nanocoating, adjust their level of ... save energy; novel diagnostic methods and tailor-made nano-medicines to ... hand, can be used to make very efficient dust ... protect vineyards from insect attack; new nanostructured materials for ...
Cached Biology Technology:NYU-Poly VP Ubell Recognized for Excellence in Online Learning 2SAIC-Frederick and Biomatrica Collaborate to Improve Molecular Analysis in Cancer Research 2SAIC-Frederick and Biomatrica Collaborate to Improve Molecular Analysis in Cancer Research 3A world without nano? Soon hard to imagine 2A world without nano? Soon hard to imagine 3
... short-term enriched housing for nonhuman primates and ... non-quarantine settings on a per diem basis. ... state-of-the-art social housing and nursery facilities. In ... CDC quarantine facilities. Primate housing and ...
... nucleic acid gel stain has bright fluorescence when ... making it ideal for detecting dsDNA in gels ... SYBR Green I nucleic acid stain has ... PCR assays and bandshift assays. A 500 µL ...
Synonym: modified Grace's Insect medium...
Schneider's Drosophila - Insect medium...
Biology Products: