Navigation Links
Neutron studies of HIV inhibitors reveal new areas for improvement
Date:8/14/2013

The first study of interactions between a common clinical inhibitor and the HIV-1 protease enzyme has been carried out by an international team with members from the US, Britain and France using neutrons at the Institut Laue-Langevin in Grenoble, France. It provides medical science with the first true picture of how an antiviral drug used to block virus replication actually works, and critically how its performance could be improved. The findings, reported in the Journal for Medicinal Chemistry, and the neutron techniques demonstrated at the ILL, will provide the basis for the design of a new generation of more effective pharmaceuticals to address issues such as drug resistance.

HIV-1 protease is essential in the life-cycle of HIV where it breaks polypeptide chains to create proteins used for replication and producing new infectious virus particles. Its key role makes it one of the most studied enzymes in the world. For the past 20 years scientists have used highly intense X-rays to investigate the best way to target and block the protease's role in spreading the virus.

However, this form of analysis has limitations. The strongest bonds between the enzyme and an inhibitor are usually relatively weak hydrogen bonds, yet hydrogen atoms are virtually invisible to X-ray analysis, leaving scientists to speculate as to how this binding takes place.

To address this uncertainty, scientists from Georgia State University, Purdue University and Oak Ridge National Laboratory in the USA and Harwell Oxford in Great Britain used neutrons at the Institut Laue-Langevin to analyse this binding. Neutrons are highly sensitive to lighter elements, allowing the team to identify the positions of every hydrogen atom involved in the system for the first time, and see which were involved in bonding. The inhibitor studied was Amprenavir (APV), first approved for clinical use in 1999, and experiments were carried out on the LADI-III (quasi-Laue neutron diffractometer) i
'/>"/>

Contact: Jenny Chapman
jenny@proofcommunication.com
Georgia State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Neutrons help explain why antibiotics prescribed for chemotherapy cause kidney failure
2. ORNLs newly licensed neutron detector will advance human disease research
3. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
4. Family studies suggest rare genetic mutations team up to cause schizophrenia
5. UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies
6. Single-cell transfection tool enables added control for biological studies
7. Studies support population-based efforts to lower excessive dietary sodium intakes
8. New scientific studies reveal Midwestern frogs decline, mammal populations altered by invasive plant
9. 3 new studies reveal added fibers impact on various health indices
10. AACR news: Studies show increasing evidence that androgen drives breast cancer
11. Deadly effects of certain kinds of household air pollution lead to call for biomarker studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , July 2, 2014 It is a ... announce the appointment of the world-renowned Thoracic and Cardiovascular ... Directors. Dr. Ginsburg, with over 34 years ... Presbyterian Hospital and Good Samaritan Regional Medical Center. Dr. ... the late 1980,s and is considered an expert in ...
(Date:7/10/2014)... , July 3, 2014 Research and ... of the "Global Gesture Recognition & Touch-Less ... Forecasts to 2020" report to their offering ... Global Gesture Recognition & Touch-Less Sensing Market to ... for a while, but the companies were unable ...
(Date:7/10/2014)... 8, 2014 Fingerprint Cards, ... design win (DW). An Asian OEM has selected FPC1021 for ... start in August 2014.   FPC is proud ... has a planned date for start of mass production in ... of SEK 5M, for delivery in the first half of ...
Breaking Biology News(10 mins):Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... type 2 diabetes, not only do waistlines matter to women, but ... discovery by a team of Swedish researchers was just published online ... some women of normal weight develop type 2 diabetes, despite not ... between enlarged fat cells and the development of type 2 diabetes ...
... − One of the most intriguing developments in recent medical ... Since its detection in 1988, over 22,000 scholarly articles (about ... new class of drugs has been developed, and 25 Phase ... the scientific and medical communities involved in ET move towards ...
... their home and car energy use by as much as ... , They explain how in The CSIRO Home Energy Saving ... Your Carbon Footprint, launched today by Innovation Minister Senator Kim ... solution will require action from every individual," Senator Carr said. ...
Cached Biology News:Size of fat cells and waist size predict type 2 diabetes in women 2International conference on endothelin 2International conference on endothelin 3Energy experts helping Australian households reduce carbon emissions 2
(Date:7/11/2014)... Scottsdale, AZ (PRWEB) July 11, 2014 ... medicine device company specializing in the soft tissue ... SureLock All-Suture Anchor System for surgeries involving the ... predictable fixation through a novel, inserter-controlled deployment method. ... lead to partial deployment, anchor pull-out, or anchor ...
(Date:7/10/2014)... 2014 Product and process impurities ... abundance and are often “lost in the noise,” ... Join presenters Dr. Rowel Tobias, Senior Scientist, Protein ... Head of Quality at Nanotherapeutics, Inc., to lear ... speed detection and quantitation while achieving the required ...
(Date:7/10/2014)... Understanding the need for better quality ... the gap that currently exists in this area, ChanTest ... portfolio of validated ion channel and GPCR cell lines. ... as ion channels control many critical physiological functions throughout ... the potential to treat a variety of human diseases. ...
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5
... Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage ... financial results for the quarter ended April 30, 2011. ... Total operating expenses for the three and nine months ... compared to $3,000 and $15,000 for the three and ...
... BioXpress Therapeutics SA, a Swiss-based biotechnology company ... ) biosimilars announced today representatives from the Company ... Convention,s One-on-One Partnering Meetings being held Jun 27-30 ... Convention Center.   BioXpress Therapeutics currently ...
... Health Care Compliance Strategies, Inc. (HCCS) , the leading ... announced the release of a new online multimedia HIPAA ... . Responding to expanded HIPAA Privacy Rule and Security ... course designed to assist healthcare vendors in providing experience-based ...
Cached Biology Technology:OncoSec Medical Reports Third Quarter 2011 Financial Results 2OncoSec Medical Reports Third Quarter 2011 Financial Results 3OncoSec Medical Reports Third Quarter 2011 Financial Results 4BioXpress Therapeutics SA to Partner the 2011 BIO International Convention 2New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 2New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 3
Goat polyclonal to Haptoglobin ( Abpromise for all tested applications). Antigen: Affinity purified human haptoglobin. Entrez GeneID: 3240 Swiss Protein ID: P00738...
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
ANTI STENOTROPHOMONAS MALTOPHILIA...
Recorder, 6", 7 Day, 1 Pen, 0 to 100°C, 220V, 50/60 Hz, for 4520, Customer Installed...
Biology Products: