In the 1970s, a group of Soviet scientists made observations that ultrasound could stimulate distinct neural pathways, but their evidence was only anecdotal, with subjects merely describing sensations of heat, pain, or vibration. In the current study, the researchers used functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to provide physiological proof of those early observations.
Study participants rested their index fingers on ultrasound transducers while having their brain activity monitored with fMRI and EEG. The scientists found that they could stimulate specific somatosensory pathways just by tweaking the ultrasound waveforms.
Tyler believes the finding has important implications for pain diagnosis.
"Current methods of diagnosing and characterizing pain can sometimes seem archaic," Tyler said. "To measure pain through mechanical stimulation, for example, physicians might touch the skin with nylon monofilaments known as von Frey hairs, or they'll stroke the skin with a paintbrush. For thermal sensory testing, patients may even plunge their hands into ice water until the pain becomes too great. We're hoping to provide physicians with more precise diagnostic tools."
Better diagnostics will lead to better therapeutics, said neuroscientist Michael Friedlander, executive director of the Virginia Tech Carilion Research Institute.
"By combining pulsed ultrasound with the techn
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