Navigation Links
Neurons made from stem cells drive brain activity after transplantation in laboratory model
Date:11/15/2012

LA JOLLA, Calif., November 15, 2012 Researchers and patients look forward to the day when stem cells might be used to replace dying brain cells in Alzheimer's disease and other neurodegenerative conditions. Scientists are currently able to make neurons and other brain cells from stem cells, but getting these neurons to properly function when transplanted to the host has proven to be more difficult. Now, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have found a way to stimulate stem cell-derived neurons to direct cognitive function after transplantation to an existing neural network. The study was published November 7 in the Journal of Neuroscience.

"We showed for the first time that embryonic stem cells that we've programmed to become neurons can integrate into existing brain circuits and fire patterns of electrical activity that are critical for consciousness and neural network activity," said Stuart A. Lipton, M.D., Ph.D., senior author of the study. Lipton is director of Sanford-Burnham's Del E. Webb Neuroscience, Aging, and Stem Cell Research Center and a clinical neurologist.

The trick turned out to be light. Lipton and his teamincluding Juan Pia-Crespo, Ph.D., Maria Talantova, Ph.D., and other colleagues at Sanford-Burnham and Stanford Universitytransplanted human stem cell-derived neurons into a rodent hippocampus, the brain's information-processing center. Then they specifically activated the transplanted neurons with optogenetic stimulation, a relatively new technique that combines light and genetics to precisely control cellular behavior in living tissues or animals.

To determine if the newly transplanted, light-stimulated human neurons were actually working, Lipton and his team measured high-frequency oscillations in existing neurons at a distance from the transplanted ones. They found that the transplanted neurons triggered the existing neurons to fire high-frequency oscillation
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Persistent sync for neurons
2. Astrocytes control the generation of new neurons from neural stem cells
3. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
4. These bots were made for walking: Cells power biological machines
5. Appetite suppressant for scavenger cells
6. How cells in the nose detect odors
7. NIH awards Penn scientists $10 million over 5 years for innovative research on single cells
8. New type of bacterial protection found within cells
9. Study sheds light on genetic clock in embryonic cells
10. Stem cell scientists discover potential way to expand cells for use with patients
11. Cells from skin create model of blinding eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Neurons made from stem cells drive brain activity after transplantation in laboratory model
(Date:12/17/2014)... fundamentally transforming the travel experience and nowhere is this ... decade, ePassports, biometric readers, and secure document scanners have ... via eGates and Automated Passport Control (APC) Kiosks at ... across the globe. According to ...
(Date:12/11/2014)... Dec. 10, 2014  That blood pressure plays a role in ... – the medical term for high blood pressure – was ... the inflatable cuff that,s used in measuring blood pressure was ... nothing new about hypertension, its triggers and its effects. In ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center ... its School of Medicine. Funding for this $50 million capital ... be publicly launched next summer. The medical ... R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in Wake ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... in a blood vessel from inside that vesselis ... injuries from high-speed collisions or falls (together referred to ... lives and nearly eliminate paraplegia (the loss of the ... of surgical repair for thoracic aortic aneurysms. "Analysis ...
... of America will hold its 93rd annual meeting on ... was founded in 1915 to promote the practice and ... highlight the interdisciplinary nature of ecology and linking research ... research will be presented at the meeting, including a ...
... guerrilla war against the human immune system for eons, but ... has exposed one of the tricks malaria uses to ... drug development. , Malaria parasites (plasmodia) are transmitted to people ... first set up shop in liver cells, then move into ...
Cached Biology News:Stent grafts: a better way to treat blunt trauma injuries 2ESA to feature wide range of UW-Madison presentations 2ESA to feature wide range of UW-Madison presentations 3ESA to feature wide range of UW-Madison presentations 4ESA to feature wide range of UW-Madison presentations 5ESA to feature wide range of UW-Madison presentations 6ESA to feature wide range of UW-Madison presentations 7ESA to feature wide range of UW-Madison presentations 8Research exposes new target for malaria drugs 2
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this year ... Sherley, director of the Adult Stem Cell Technology Center, LLC ... under appreciated unique property of adult tissue stem cells. ... the Past, Important for the Future,” embodied the essence of ...
(Date:12/24/2014)... MD (PRWEB) December 23, 2014 On ... H.R. 83, the Omnibus and Continuing Resolution Appropriations Act ... a condition eligible to receive funding through the Congressionally ... of Defense (DoD). The Hydrocephalus Association (HA), working in ...
(Date:12/24/2014)... December 23, 2014 The report ... its definition, classification, application and industry overview. This ... product cost structure. Production is separated by regions, ... raw materials, equipment, downstream client survey, marketing channels, ...
(Date:12/24/2014)... report expects global cell isolation and expansion market to grow ... data about the vital drivers, restraints, trends, opportunities, strategies and ... http://bit.ly/1yUxy0T , According to the report, the global ... impressive CAGR during near future. It expects this growth to ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... ROCKVILLE, Md., March 17 Novavax, Inc. (Nasdaq: ... fourth quarter financial results in a press release to be ... The Company will hold an investor conference call to discuss ... 30, 2009. The call will be hosted by Novavax President ...
... /PRNewswire-FirstCall/ - BioMS Medical Corp. (TSX: MS), a leading ... announced financial and operational results for the year ended ... to safely affect MS progression in previous studies and ... trial (MAESTRO-01) in the second half of this year," ...
... Magellan Biosciences, an emerging leader in systems for ... North American Product Innovation Award for LeadCare II, ... adults to be screened for lead poisoning faster, ... Diagnostics, James Whelan, will accept the award tomorrow ...
Cached Biology Technology:Novavax Announces Release Date of 2008 Fourth Quarter Financial Results and Investor Conference Call 2Novavax Announces Release Date of 2008 Fourth Quarter Financial Results and Investor Conference Call 3BioMS Medical Announces 2008 Year End Results 2BioMS Medical Announces 2008 Year End Results 3BioMS Medical Announces 2008 Year End Results 4BioMS Medical Announces 2008 Year End Results 5BioMS Medical Announces 2008 Year End Results 6BioMS Medical Announces 2008 Year End Results 7BioMS Medical Announces 2008 Year End Results 8BioMS Medical Announces 2008 Year End Results 9BioMS Medical Announces 2008 Year End Results 10BioMS Medical Announces 2008 Year End Results 11Magellan to Receive Frost & Sullivan 2009 North American Product Innovation Award; Three-Minute LeadCare(R) II Test Identifies Children with Lead Poisoning 2Magellan to Receive Frost & Sullivan 2009 North American Product Innovation Award; Three-Minute LeadCare(R) II Test Identifies Children with Lead Poisoning 3Magellan to Receive Frost & Sullivan 2009 North American Product Innovation Award; Three-Minute LeadCare(R) II Test Identifies Children with Lead Poisoning 4
The LIC Duet™ Mini Adaptor encodes a T7 promoter, lac operator, ribosome binding site (rbs), and an ATG translation initation codon. This adaptor is designed for expression of a target protei...
... these culture chambers produce cell yields in ... range and are useful alternatives to multiple ... mechanical • strength and structural integrity • ... Certified nonpyrogenic and sterilized by gamma irradiation, ...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
...
Biology Products: