Navigation Links
Neuronal activity induces tau release from healthy neurons
Date:2/15/2013

HEIDELBERG, 15 February 2013 Researchers from King's College London have discovered that neuronal activity can stimulate tau release from healthy neurons in the absence of cell death. The results published by Diane Hanger and her colleagues in EMBO reports show that treatment of neurons with known biological signaling molecules increases the release of tau into the culture medi-um. The release of tau from cortical neurons is therefore a physiological process that can be regulated by neuronal activity.

Tau proteins stabilize microtubules, the long threads of polymers that help to maintain the structure of the cell. However, in Alzheimer's disease or certain types of dementia, tau accumulates in neurons or glial cells, where it contributes to neurodegeneration.

In addition to intracellular aggregation, recent experiments have shown that tau is released from neuronal cells and taken up by neighboring cells, which allows the spread of aggregated tau across the brain. This release could occur passive-ly from dying neuronal cells, though some evidence suggests it might take place before neuronal cell death and neurodegeneration. The new findings indicate that tau release is an active process in healthy neurons and this could be altered in diseased brains.

"Our findings suggest that altered tau release is likely to occur in response to changes in neuronal excitability in the Alzheimer's brain. Secreted tau could therefore be involved in the propagation of tau pathology in tauopathies, a group of neurodegenerative diseases associated with the accumulation of tau proteins in the brain," commented Diane Hanger, Reader in the Department of Neuroscience at King's College London. In these experiments, Amy Pooler, the lead au-thor, revealed that molecules such as potassium chloride, glutamate or an AM-PA receptor agonist could release tau from cortical neurons in an active physio-logical process that is, at least partially, dependent on pre-synaptic vesicle se-cretion.

The new findings by the scientists indicate that tau has previously unknown roles in biological signaling between cells, in addition to its well-established role in stabilizing microtubules.

"We believe that targeting the release of tau could be explored as a new thera-peutic approach for the treatment of Alzheimer's disease and related tauopa-thies," said Hanger. Additional studies are needed in model organisms to test this hypothesis further.


'/>"/>

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Related biology news :

1. Researchers have identified a gene with a key role in neuronal survival
2. Ion selectivity in neuronal signaling channels evolved twice in animals
3. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
4. Cilia guide neuronal migration in developing brain
5. Activity in brain networks related to features of depression
6. High levels of TRAIL protein in breast milk might contribute to anticancer activity
7. NASAs new satellite movie of 1 weeks ash activity from Mexicos Popocatepetl Volcano
8. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
9. The activity of a bacterial effector protein seen in molecular detail
10. UTHealth study addresses barriers to physical activity counseling
11. Environmental estrogens affect early developmental activity in zebrafish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... YORK , March 21, 2017 ... Marketing Cloud used by retailers such as 1-800-Flowers ... its platform — Product Recommendations and Replenishment. Using Optimove,s ... give more personalized product and replenishment recommendations to ... but also on predictions of customer intent drawn ...
(Date:3/16/2017)... March 16, 2017 CeBIT 2017 - Against identity fraud with DERMALOG ... ... Used combined in one project, multi-biometric solutions provide a crucial contribution ... Used combined in one ... ...
(Date:3/7/2017)... England , March 7, 2017 Brandwatch , ... chosen by The Prince,s Trust to uncover insights to ... across The Trust. The UK,s leading youth charity will ... social campaign results and get a better understanding of the topics ... ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... 28, 2017 /PRNewswire/ -RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSXV: ... compelling safety and clinical data from its phase 1/2 tendon ... hair follicle-derived fibroblasts (RCT-01) as a treatment for Achilles tendinosis. ... ... safety profile at 6 months and showed no serious adverse ...
(Date:3/27/2017)... N.J. , March 27, 2017 Roka Bioscience, ... advanced testing solutions for the detection of foodborne pathogens,  today ... the Sidoti & Company Spring 2017 Convention on March 29 ... New York Marriott Marquis. About Roka Bioscience ... ...
(Date:3/27/2017)... ... March 27, 2017 , ... Biopsies from non-small cell lung ... limited tumor content in a large background of normal or wild type cells. ... for reliable detection of low abundance somatic mutations, particularly in small specimens with ...
(Date:3/27/2017)... 2017  Perthera,s Chief Bioinformatics Officer and research faculty ... , Ph.D., will be speaking at the American Medical ... March 27, 2017, she will be speaking on the ... Research and Care" (from 10:30 a.m. – 12:00 p.m. ... be a participant in the "Making Precision Oncology Data ...
Breaking Biology Technology: