Navigation Links
'Neurological work-arounds' offer hope to people with monoamine-related disorders
Date:2/20/2009

Researchers have known for decades that the brain has a remarkable ability to "reprogram" itself to compensate for problems such as traumatic injury. Now, a research article published in the February 2009 issue of the journal Genetics (http://www.genetics.org) suggests that the brain may also be able to compensate for problems with key neurotransmitters such as serotonin and dopamine. This finding may open the doors to entirely new lines of research and treatments for a wide range of brain disorders, including addiction, depression, Parkinson's disease, and schizophrenia.

David Krantz, Associate Professor at the University of California, Los Angeles and Anne Simon, now an Assistant Professor at York College of the City University of New York were the two lead investigators on the study. "Illnesses such as depression, addiction, schizophrenia and Parkinson's disease devastate millions of lives each year. Current treatment strategies often fail and remain poorly understood," said Krantz. "In our research, we have discovered a simple way to identify the functional changes that may be associated with these illnesses and to research new drugs."

To reach this conclusion, Krantz, Simon and colleagues bred fruit flies with what should have been a devastating, life-threatening mutation in the vesicular monoamine transporter gene. This mutation caused their brain cells to be unable to release monoamine neurotransmitters such as serotonin and dopamine. Fruit flies were used in the study because they are convenient for genetic experiments and have a set of neurotransmitters that is nearly identical to that of humans. And as is the case with humans, monoamine neurotransmitters are considered necessary for the fly to function normally. The researchers observed that although the mutant fruit flies crawled less as larvae and were infertile as adults, they lived and were surprisingly healthy in many respects. This
'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biologists discover link between CGG repeats in DNA and neurological disorders
2. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
3. MNI researchers locate neurological basis of depression following sports concussion
4. New paper offers key insights into how new species emerge
5. Studies offer guide as protein interaction mapping comes of age
6. UC Davis discovery offers hope for treating kidney cancer
7. International public-private partnership offers new paradigm for medicinal chemistry
8. Rong Li Lab offers insight into adaptive ability of cells
9. New papers offer insights into process of malarial drug resistance
10. Light pollution offers new global measure of coral reef health
11. Ripple effect: Water snails offer new propulsion possibilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... edge technologies including Wocket™, the Smart Wallet, at the ... FiRe is a leading global conference on the intersection ... by Mark Anderson , founder and publisher of ...
(Date:10/15/2014)... pandemic risk from strains of influenza virus increases with ... to become complacent that the most substantial threats have ... Influenza pandemics arise when a new virus strain – ... – spreads in the human population. There have been ... worst of which – the 1918 Spanish Flu – ...
(Date:10/15/2014)... German Gauß-Allianz has admitted Johannes Gutenberg University Mainz ... Rhineland-Palatinate science hub continues to maintain a significant ... , "The acceptance of Johannes Gutenberg University ... is a milestone in the national and international ... The state of Rhineland-Palatinate can be proud that ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... Coral reefs are among the most diverse ecosystems ... Bird,s nest coral ( Seriatopora hystrix ) is common ... a range of depths. However, there is little gene ... even the algal endosymbionts (Symbiodinium), which provide energy for ...
... - For the first time, researchers have found a way ... directly into a single living cell without a needle. ... through a tiny channel and into a cell in a ... colleagues at Ohio State University describe the technique in the ...
... number of areas in the human genetic code that are ... in a new study of over 61,000 people, published today ... is an international collaboration led by Imperial College London and ... of which had not been linked to liver function before. ...
Cached Biology News:Deep-reef coral hates the light, prefers the shade 2Researchers do precise gene therapy without a needle 2Researchers do precise gene therapy without a needle 3Largest ever genetic study of liver function could point the way to new treatments 2
(Date:10/22/2014)... Diego, CA (PRWEB) October 22, 2014 ... balances from Sartorius, A & D Weighing, Rice ... Sartorius CPA Semi-Micro Balance . The Sartorius CPA ... for an affordable high-quality, precise, and user-friendly laboratory ... manufacturing of laboratory equipment, their laboratory balances are ...
(Date:10/22/2014)... --  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... and diseases, announced today that the U.S. Patent and ... a composition of matter patent application that covers the ... This is Synthetic Biologics, first allowed patent application directly ... the Company,s extensive C. difficile patent estate. ...
(Date:10/22/2014)... HONG KONG , Oct. 22, 2014 /PRNewswire/ ... announced today that rare disease expert John C. ... research. Dr. McKew brings more than two decades of ... the National Institutes of Health, Wyeth Research and Genetics ... will lead aTyr,s efforts to expand and translate its ...
(Date:10/20/2014)... 20, 2014 Asterias Biotherapeutics, Inc. (NYSE ... signed a Notice of Grant Award (NGA) with ... October 1, 2014.  The NGA provides for the ... release of additional grant funds pursuant to the ... clinical development of Asterias, product, AST-OPC1. The grant ...
Breaking Biology Technology:Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4
... than half-a-century ago, the Dutch theoretical physicist Hendrik Casimir ... a vacuum would attract. The mysterious force arises from ... of existence, as described by quantum theory. Now Norio ... Japan, has predicted that in certain circumstances a reversal ...
... Life Sciences, Inc. (NASDAQ: SRLS ), a ... to facilitate the discovery, development and production of human ... of shareholders held today, its shareholders voted to adopt ... Project Plasma Merger Corp., affiliates of Linden Capital Partners. ...
... April 17, 2012 Senior clinical ... Shire and GSK, met recently at the US ... and define competencies for a global competition to ... South America. The US Clinical Researcher ...
Cached Biology Technology:SeraCare Shareholders Approve Acquisition by Linden Capital Partners 2SeraCare Shareholders Approve Acquisition by Linden Capital Partners 3Quality Standards Established for Competition to Identify Best Researchers in the US 2
... G bind specifically to Fc regions of ... G conjugates are commonly used as affinity ... subtypes from serum, hybridoma ascites fluids, tissue ... reagents are also commonly used to capture ...
... and Protein G bind specifically to Fc ... and Protein G conjugates are commonly used ... and immunoglobulin subtypes from serum, hybridoma ascites ... fluids. These reagents are also commonly used ...
... dishes with stacking feature for easy storage. Linkage: ... created to easily match Cornings product number. If ... old Sigma-Aldrich number (Z70,947-6) or contact customer service ... Comp Dim: surface area 55 cm 2 ...
... thermal cycler blocks, 96-well PCR plate, 0.3ml maximum ... seals), Cut-away corner , Fits all 0.2ml thermal ... capillary sequencers, Clear well bottom for sample visibility, ... Films and Foils, Heat Seals and Flat and ...
Biology Products: