Navigation Links
Neurobiology: The logistics of learning
Date:12/20/2013

ignificance of the model, the molecular mechanisms required for its realization have remained obscure. mRNA-binding proteins, including Staufen2 (Stau2) and Barentsz, are essential components of the granules, and Kiebler's team, in collaboration with Giulio Superti-Furga's group (CeMM, Vienna), have now used specific antibodies to isolate and characterize neuronal granules that contain either Stau2 or Barentsz.

Surprising diversity

It has generally been assumed that all neuronal RNA granules have essentially similar compositions. However, the new findings indicate that this is not the case. A comparison between Stau2- and Barentsz-containing granules reveals that they differ in about two-thirds of their proteins. "This suggests that the RNA granules are highly heterogeneous and dynamic in their composition," says Kiebler. "And that makes sense to me, because it would mean that the granules can perform different functions depending on which mRNAs they carry." Furthermore, the researchers have shown that the granules contain virtually none of the factors known to promote the translation of mRNAs into proteins. On the contrary, they include many molecules that repress protein synthesis. This in turn implies that the process of mRNA transport is uncoupled from the subsequent production of the proteins they encode.

In a complementary study, Kiebler's team also characterized the mRNA cargoes associated with the granules. "Until now, none of the RNA molecules present in Stau2-containing granules in mammalian nerve cells had been defined, but we have now been able to identify many specific mRNAs," Kiebler explains. Further experiments revealed that Stau2 stabilizes the mRNAs, allowing them to be used more often for the production of proteins. Moreover, the researchers have shown that specialized structures within these mRNAs, called "Staufen-Recognized Structures" (SRS), are essential for their recognition and stabilization by Stau2. "This
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Developmental neurobiology: How the brain folds to fit
2. Biologistics: How fast do chemical trains move in living cells?
3. New logistics services that will cut energy consumption and CO2 emissions
4. Majority-biased learning
5. Awake mental replay of past experiences critical for learning
6. Dartmouth researchers are learning how exercise affects the brain
7. Songbirds learning hub in brain offers insight into motor control
8. New Genetics educational resource promotes active learning
9. New model gives hands-on help for learning the secrets of molecules
10. Learning faster with neurodegenerative disease
11. Learning from each other -- growing together
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... A new study shows that legume plants regulate ... cytokininssignaling molecules that are transmitted through the plant ... the number of bacteria-holding nodules in the roots. ... the National Institute for Basic Biology, the Graduate ... Center for Sustainable Resource Science in Japan. ...
(Date:9/18/2014)... Colo., USA Miranda, a small, icy moon of ... enigmatic bodies in the solar system. Despite its relatively ... of intense resurfacing that resulted in the formation of ... polygonal-shaped regions called coronae. , These coronae are ... at least 200 km across. Arden corona, the largest, ...
(Date:9/18/2014)... "frequent flyers" program, fruit flies surely would be eligible ... increasing numbers of fruit fly research studies. One fruit ... and another is scheduled launch to the station Sept. ... December. , Fruit flies are biomedical research models studied ... organisms can reveal the basis for health and disease ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4
... MIAMI March 10, 2011 -- Scientists from the University ... were part of a national research team to find two ... Horizon oil spill. In a study published in this week,s ... offers new insight into the mechanism by which the crude ...
... of California, San Francisco (UCSF) has developed a new ... but untreatable and incurable neurodegenerative disease. The disease, frontotemporal ... dementia before age 65, after Alzheimer,s disease. Based ... work explains in part why the brain deteriorates in ...
... New Orleans, LA LSU oncologist Vince D. ... article reporting two chemotherapy drugs now indicated for second ... cancer are remarkably effective in treating a certain subset ... of Medicine at LSU Health Sciences Center New Orleans ...
Cached Biology News:New study reveals aerosol plumes downwind of the Deepwater Horizon oil spill 2UCSF report describes new model for neurodegeneration 2UCSF report describes new model for neurodegeneration 3Study shows new treatment strategy effective for certain lung cancers 2
(Date:9/19/2014)... September 19, 2014 Barnhardt Manufacturing ... Label for its Organic Cotton . The USDA ... of renewable biobased ingredients meets or exceeds levels set ... composed in whole or in significant part of agricultural, ... allow our Organic cotton to be immediately identified as ...
(Date:9/19/2014)... Massachusetts , September 19, 2014 ... the 53rd European Society for Paediatric Endocrinology (ESPE) Meeting  ... of science and medical research in the field of ... Merck KGaA, Darmstadt, Germany , today ... Innovation (GGI) for 2014. The awards were announced during ...
(Date:9/18/2014)... 18, 2014 HealthTronics, Inc ... interventional radiology products and services, announced that a ... and cryoablation) versus external beam radiotherapy (EBRT) is ... American Urological Association (MAAUA) Annual Meeting in Baltimore, ... Effectiveness of Cryosurgery and External Beam Radiation as ...
(Date:9/18/2014)... 2014 A novel robotic system that ... is currently being tested as part of a biomedical ... Boston with the aim of determining if the robot, ... cancer biopsies faster, more accurate, less costly, and less ... the potential to deliver prostate cancer therapies with greater ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6
... Directors,of Eli Lilly and Company (NYSE: LLY ) ... December 1, 2008. Oberhelman, 55, currently serves as,a group ... Caterpillar,s,executive office. As a member of Lilly,s board, Oberhelman ... committee. He will stand for,election by Lilly shareholders at ...
... KANNAPOLIS, N.C., Oct. 20 Academia, science, industry,and ... at 10,AM at the Dedication and Open House ... the UNC Nutrition Research Building and the NC,State ... Nutrition,Research Building is home to NC A&T University, ...
... Recruitment, and Employment Branding joins Pierpoint International as Global VP of ... ... (PRWEB) October 20, 2008 -- Pierpoint International is pleased to announce ... and Diversity. Mr. Cantu, most recently served as AVP of Staffing ...
Cached Biology Technology:Douglas Oberhelman Elected to Lilly Board of Directors 2Douglas Oberhelman Elected to Lilly Board of Directors 3Campus Celebrates Historic Milestone 2Campus Celebrates Historic Milestone 3Campus Celebrates Historic Milestone 4Campus Celebrates Historic Milestone 5Robert Cantu Appointed Vice President of Pierpoint International 2
Peptide-affinity Purified Polyclonal Antibody to Olfactory Receptor, Family 2, Subfamily H, Member 3...
... collects data from balances and scales with RS232 ... other program. If you can type the weight ... collection process Simple to use parser extracts ... , Add user information , Collect data at ...
... collection and automation that is controlled from within ... , Pre-configured library of interfaces for balances, ... be added and configured by the user ... one spreadsheet , Allows for multi-tasking ...
...
Biology Products: