Navigation Links
Neurobiology: The logistics of learning
Date:12/20/2013

ignificance of the model, the molecular mechanisms required for its realization have remained obscure. mRNA-binding proteins, including Staufen2 (Stau2) and Barentsz, are essential components of the granules, and Kiebler's team, in collaboration with Giulio Superti-Furga's group (CeMM, Vienna), have now used specific antibodies to isolate and characterize neuronal granules that contain either Stau2 or Barentsz.

Surprising diversity

It has generally been assumed that all neuronal RNA granules have essentially similar compositions. However, the new findings indicate that this is not the case. A comparison between Stau2- and Barentsz-containing granules reveals that they differ in about two-thirds of their proteins. "This suggests that the RNA granules are highly heterogeneous and dynamic in their composition," says Kiebler. "And that makes sense to me, because it would mean that the granules can perform different functions depending on which mRNAs they carry." Furthermore, the researchers have shown that the granules contain virtually none of the factors known to promote the translation of mRNAs into proteins. On the contrary, they include many molecules that repress protein synthesis. This in turn implies that the process of mRNA transport is uncoupled from the subsequent production of the proteins they encode.

In a complementary study, Kiebler's team also characterized the mRNA cargoes associated with the granules. "Until now, none of the RNA molecules present in Stau2-containing granules in mammalian nerve cells had been defined, but we have now been able to identify many specific mRNAs," Kiebler explains. Further experiments revealed that Stau2 stabilizes the mRNAs, allowing them to be used more often for the production of proteins. Moreover, the researchers have shown that specialized structures within these mRNAs, called "Staufen-Recognized Structures" (SRS), are essential for their recognition and stabilization by Stau2. "This
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Developmental neurobiology: How the brain folds to fit
2. Biologistics: How fast do chemical trains move in living cells?
3. New logistics services that will cut energy consumption and CO2 emissions
4. Majority-biased learning
5. Awake mental replay of past experiences critical for learning
6. Dartmouth researchers are learning how exercise affects the brain
7. Songbirds learning hub in brain offers insight into motor control
8. New Genetics educational resource promotes active learning
9. New model gives hands-on help for learning the secrets of molecules
10. Learning faster with neurodegenerative disease
11. Learning from each other -- growing together
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... N.Y., July 25, 2014 In the first broad-scale estimate ... Service scientists and collaborators calculated that trees are saving ... 670,000 incidences of acute respiratory symptoms. , While trees, ... of less than 1 percent, the impacts of that ... of the reduced air pollution at nearly $7 billion ...
(Date:7/25/2014)... era, 100,000s of people lived on the land now ... to control the availability of plants they used for ... use fire to maintain desired habitat and natural resources. ... Service,s Pacific Southwest Station, will lead a field ... during the Ecological Society of America,s 99th Annual Meeting, ...
(Date:7/25/2014)... from the Terra satellite show the different areas that have ... Russia. The burn scars show up as reddish-brown splotches ... broken across the remote parts of Eastern Russia in the ... MODIS instrument, it is still possible to see the ... features noted below show the devastating number of fires that ...
Breaking Biology News(10 mins):First national study finds trees saving lives, reducing respiratory problems 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... at Chapel Hill shows how a protein may be crucial ... protein, called "eed," is needed for an essential chemical modification ... findings appear in the May 24 issue of the journal ... a new wave of thinking in genetics: that not all ...
... most, the mere mention of the word "virus" stirs ... suffering. But in recent years, scientists have been trying ... the fight against cancer. , Through genetic engineering, viruses ... abilities to infiltrate, commandeer, replicate and destroy, but only ...
... Howard Hughes Medical Institute have succeeded in mapping the ... range of odors, including vanilla, skunk, fish, urine, musk, ... of neural activity represents a significant step in understanding ... in the nose into odor perception in the brain, ...
Cached Biology News:Protein helps regulate the genes of embryonic stem cells 2Turning viruses into allies against cancer 2Turning viruses into allies against cancer 3Turning viruses into allies against cancer 4Decoding the logic of olfaction 2Decoding the logic of olfaction 3Decoding the logic of olfaction 4
(Date:7/25/2014)... (PRWEB) July 25, 2014 At the ... has granted a 60-day extension for the public comment ... Special Rule for Model Aircraft established by Congress as ... 2012. The 60-day extension establishes the new deadline for ... States Department of Transportation/FAA notice published in the Federal ...
(Date:7/24/2014)... -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the ... Phase 3 study of Zerenex (ferric citrate), the Company,s ... of hyperphosphatemia in patients with end-stage renal disease (ESRD) ... delivery with FErric CiTrate in EsrD) was published online ... of Nephrology ( JASN ). , ...
(Date:7/24/2014)... Gain recognition for leadership and ... the biotech industry. Nominations are now being accepted ... you by the Bio Supply Management Alliance ... management professionals for the past 7 years. , ... Biotech industry – Manufacturers, Service Providers, Material Suppliers, ...
(Date:7/24/2014)... 24, 2014  Asterias Biotherapeutics, Inc. (OTCBB: ASTYV), ... of regenerative medicine, announced today that it will ... investors on Tuesday, July 29, 2014, at 4:30 ... include an overview of Asterias, business strategy and ... http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 minutes before ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4
... database to explore, understand, manage, and share next-generation ... Inc., the leader in sequence data management, today ... Expression Workflow designed to enable researchers working with ... is the second such workflow to be delivered ...
... May 5 Sequella, Inc., a clinical-stage biopharmaceutical company ... start of its Phase 1B trial for SQ109 with ... a new diamine antibiotic intended to replace one or ... patient therapy, was granted U.S. FDA Fast Track designation ...
... influenza virus-like particle (VLP) vaccine progresses with study designed ... May 5 Novavax, Inc. (Nasdaq: NVAX ... second clinical trial of its virus-like particle (VLP) seasonal ... this Phase II randomized, placebo controlled clinical trial has ...
Cached Biology Technology:GenomeQuest, Inc. Announces Digital Gene Expression Solution Within Its Sequence Data Management Platform 2Sequella Commences Phase 1B Study for New Tuberculosis Drug SQ109 2Novavax Announces Enrollment in the Second Phase II Study of its Seasonal Influenza VLP Vaccine Candidate 2Novavax Announces Enrollment in the Second Phase II Study of its Seasonal Influenza VLP Vaccine Candidate 3Novavax Announces Enrollment in the Second Phase II Study of its Seasonal Influenza VLP Vaccine Candidate 4
This kit is designed to select cells labeled with biotinylated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
... Hamamatsu C9136 FLIM system combines the space and ... the resolution of the optical microscope to open ... short, pulsed light source for excitation, the decay ... the lifetime of the decay measured. Subtle ...
... ScriptCap™ m7G Capping system features ... all of the components needed ... on the end of di- ... kits feature high efficiency capping ...
Extracti-Gel D Detergent Removing Gel...
Biology Products: