Navigation Links
Neurobiologist Rodal wins New Innovator award
Date:9/14/2012

cle, which used to be the edge of the cell. Once pinched in, this vesicle contains and growth factors

In studying how growth factors are internalized into the cell and how they move through the neuron, Rodal's lab has developed new microscopy techniques that give them the ability to observe the process in real time in fruit fly neurons.

Her hypothesis is that electrical activity in neurons lead to a change in how growth factor receptors are moving back and communicating to the neuron, telling it whether it should grow, survive, or become stronger or weaker.

"What I wanted to do in this project was to draw the connection between firing of the neuron and traffic of these receptors," says Rodal. "I'm in a good position to do that is because I have this great model system where I can make neurons fire the way I want them to, and I can look at the receptors trafficking."

Rodal wants to know: does a neuron that fires a lot shunt its growth factors faster, or is it something completely different? The other part of her project involves purifying the molecular machines that drive these different methods of transportation to see how they are different between neurons that are firing frequently versus infrequently. This work will pinpoint strategies that healthy neurons use to alter growth signaling, giving researchers new ideas for therapeutics to correct growth signaling defects in neurodegenerative disease patients.

"In Lou Gehrig's disease, motor neurons that innervate your finger die, in part because they lack these growth factors," says Rodal. "In neurodegenerative diseases, the molecular machines that drive membrane traffic go wrong. We'd like to be able to turn growth factor signaling back into a healthy state, and to do that, we need to know what's happening to each one of these machines that moves things from one compartment to another."


'/>"/>
Contact: susan Chaityn Lebovits
lebovits@brandies.edu
781-736-4027
Brandeis University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New book on stereology by Mark West is essential reading for neurobiologists
2. A rare feat: 2 scientists at Salk score NIH New Innovator Awards
3. NIH New Innovator Award helps Sanford-Burnham scientist pursue high-risk, high-reward project
4. ONR-funded young innovators recognized by President
5. Madidi conservationist wins award at World Conservation Congress
6. MARC travel awards announced for 2012 American Society for Bone & Mineral Research annual meeting
7. MARC travel awards announced for the 2012 APS Integrative Biology of Exercise meeting
8. MARC travel awards announced for the 2012 SACNAS Annual Meeting
9. Stanford bioengineer Christina Smolke wins NIH Directors Pioneer Award
10. Daniel Kahnemans Thinking, Fast and Slow wins best book award from academies
11. NIBIB and HHMI announce graduate biomedical training awards
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Neurobiologist Rodal wins New Innovator award
(Date:7/31/2014)... from shale rock has increased by more than ... not fully understand the industry,s effects on nature ... journal Frontiers in Ecology and the Environment ... outpace scientific examination, a team of eight conservation ... University, concluded that determining the environmental impact of ...
(Date:7/31/2014)... New research, supported by the National Science Foundation ... permafrost uniformly accelerates atmospheric warming, indicating instead that ... they emit into the atmosphere. , The ... Nature , focuses on thermokarst lakes, which occur ... fill with melted fresh water, converting what was ...
(Date:7/31/2014)... biomass burning burning forests to create agricultural ... agriculture and wildfires figures into both climate ... release of a new study by Stanford University ... the degree of that contribution had never been ... paper published July 30 in the Journal ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Certain Arctic lakes store more greenhouse gases than they release 2Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4
... the world, this week,s edition of Chemical & Engineering ... on the jobs situation for chemists -- whose work directly ... chemical industry in the United States alone a $674 billion ... American Chemical Society, the world,s largest scientific society. ...
... life scientists have identified a gene that slows the aging ... activated a gene called PGC-1, which increases the activity of ... growth and tell cells when to live and die. ... in different cells and tissues of the fly and asked ...
... tree outside Oak Ridge National Laboratory researcher Pratul Agarwal,s ... may ultimately lead to drugs with fewer side effects, ... breeze causes leaves, branches and ultimately the tree to ... of chemical processes that have a ripple effect necessary ...
Cached Biology News:UCLA biologists slow the aging process in fruit flies 2UCLA biologists slow the aging process in fruit flies 3ORNL fundamental discovery casts enzymes in new light 2
(Date:7/31/2014)... 2014 CollabRx, Inc. (NASDAQ: CLRX), a ... in oncology, today announced that it will hold an ... the Company's financial results for the first quarter of ... business in the current fiscal year. , The dial-in ... August 14, 2014, at 5 p.m. EDT (2 p.m. ...
(Date:7/31/2014)... Francisco, Calif. (PRWEB) July 31, 2014 ... newly diagnosed patients with an overview of the disease ... management of drug side effects, as well as updates ... “We’re grateful to Dr. Sandy Srinivas for organizing this ... survivor of kidney cancer. “Sandy and her colleagues have ...
(Date:7/31/2014)... 2014 “Rapid technological advances will ... U.S., increasing unemployment, depressing American consumer spending and ... a Catch 22—we need automated manufacturing if we ... jobs,” says economist and corporate relocation expert Dr. ... 10 Pro-Business States for 2014, co-published with the ...
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3
... Leading US Spine Centers Committed to the IEP,s ... 24 Magnifi Group, considered by,many industry observers ... within the medical device and pharmaceutical industries,announced here ... annual,meeting, its intent to organize and develop real-time ...
... Efforts to ... MENTOR, Ohio, Oct. 24 STERIS Corporation,(NYSE: STE ... its,VaproSure(TM) Room Sterilizer from several U.S. hospitals. The VaproSure,Room Sterilizer ... kind for the healthcare market. Since being introduced in,June of ...
... Cell Therapeutics,Inc. (CTI) (Nasdaq and MTAX: ... annual AACR-NCI-EORTC Symposium show its bis-platinate drug,candidates, ... currently,marketed platinum agents carboplatin, cisplatin and oxaliplatin. ... late 2008. "Bis-platinates represent a promising ...
Cached Biology Technology:Magnifi Group Demonstrates Industry's First Interactive Educational Program (IEP) for Spine Fellows 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 3Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 4Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 5Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 6First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 2First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 3
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
... et.al. (1997) • Contains short ... biochemistry & molecular biology, arranged ... Entries give details of biochemical ... which they are involved and ...
The Protein Kinase Factsbooks (2 Volume Set)...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Biology Products: