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NeuroPhage discovers GAIM-changing molecules to combat Alzheimer's and related diseases
Date:4/22/2014

Cambridge, MA, April 22, 2014 Researchers from NeuroPhage Pharmaceuticals, Inc. have engineered a series of molecules with the potential to treat most neurodegenerative diseases that are characterized by misfolded proteins, such as Alzheimer's, Parkinson's and Huntington's diseases. These molecules are based on what the Company calls a general amyloid interaction motif, or GAIM, which recognizes a characteristic common to many toxic, misfolded proteins, not just one type of misfolded protein. This approach provides NeuroPhage with an array of therapeutic targets, so that a number of pathologies, such as amyloid beta plaques, tau tangles and alpha-synuclein Lewy bodies, can all be addressed simultaneously with a single drug candidate. In addition, the Company has shown that the GAIM molecules can not only prevent the formation of new toxic protein aggregates but can also clear existing aggregates in the form of both soluble oligomers and insoluble fibers, such as plaques and tangles.

"The research published today describes GAIM, NeuroPhage's unique approach to treat diseases characterized by misfolded proteins. GAIM has the potential to provide a more robust response than previous therapies because it enables the simultaneous targeting of multiple pathologies within a single disease," said Dr. Richard Fisher, Chief Scientific Officer at NeuroPhage.

This novel and revolutionary approach was published online today in the Journal of Molecular Biology. The publication, "A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies," was authored by Rajaraman Krishnan et al. For more information, please visit: http://bit.ly/1lqwIUg.

"Symptoms of neurodegenerative diseases often appear well after the troublesome aggregates have begun to accumulate in the brain. By then, therapies that only target newl
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Contact: Michelle Avery
mavery@macbiocom.com
781-235-3060
MacDougall Biomedical Communications, Inc.
Source:Eurekalert  

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NeuroPhage discovers GAIM-changing molecules to combat Alzheimer's and related diseases
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