Navigation Links
Neural stem progenitor cell transplantation’s potential to aid spinal cord injury tested
Date:7/11/2011

Tampa, Fla. (July. 11, 2011) A study published in the current issue of Cell Transplantation (20:5) investigating optimal routes for transplanting neural stem/progenitor cells (NS/PCs) in animal models of spinal cord injury (SCI) has demonstrated that intralesional (IL) injection conferred benefits over intravenous injection (IV) and intrathecal (IT) injection. The study, by a team of Keio University (Japan) researchers, is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

"Spinal cord injury usually results in severe, paralytic damage because the adult central nervous system has little potential for regeneration after injury," said corresponding author Dr. Masaya Nakamura of the Keio University School of Medicine's Department of Orthopedic Surgery. "With cell transplantation of neural stem/progenitor cells being a promising strategy, our study sought to determine the best method of application for optimal cell survival and subject safety."

For their study, the researchers used a new reporter gene, called "ffLuc," a novel fusion protein, for bioluminesence (BLI) imaging in order to track the transplanted cells via MRI from injection site to spinal cord lesion.

"MRI signals from dead cells cannot be distinguished from those of living cells," noted Dr. Nakamura. "To overcome this difficulty, we used a BLI system that tracked only living cells."

After inducing SCI in mouse models, the researchers compared the safety and efficacy results of IL, IT and IV injection methods for transplanting NS/PCs. IL grafting emerged as the best method since the IL-injected animals showed the best survival rates for grafted cells post-injection with no complications in the animals. IT injection showed low animal survival rates. IV injection resulted in no grafted cells migrating to the SCI lesion sites and many of the test animals died of a pulmonary embolism soon after injection.

"Taken together, our findings indicate that the best method for transplanting NS/PCs into the spinal cord injury site is by intralesional injection," summarized Dr. Nakamura.

"It is interesting that this study observed the greatest cell survival after neural stem cell transplantation directly into the lesion site after spinal cord injury" said Dr. Paul Sanberg, coeditor-in-chief of Cell Transplantation and executive director of the University of South Florida Center of Excellence for Aging and Brain Repair. "It will be of considerable importance to determine if this finding translates to increased recovery and also whether this translates to other disorders".


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Neural mechanisms of value bias in the human visual cortex
2. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
3. I feel your pain: Neural mechanisms of empathy
4. Neural mapping paints a haphazard picture of odor receptors
5. Ex vivo neural stem cell expansion
6. Low levels of vitamin B12 may increase risk for neural tube defects
7. Early brain activity sheds new light on the neural basis of reading
8. Creating ideal neural cells for clinical use
9. Identification of a key molecular pathway required for brain neural circuit formation
10. Neural stem cell differentiation factor discovered
11. Essential nutrient found in eggs may help lower risk of neural tube defects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... Florida , March 14, 2016 ... the growing mobile commerce market, announces the airing of a ... channels starting the week of March 21 st .  The ... CNBC, including its popular Squawk on the Street show. ... focused on the growing mobile commerce market, announces the airing ...
(Date:3/11/2016)... --> --> ... Recognition Market by Technology (Pattern Recognition), by Component (Hardware, ... Type (On-Premises and Cloud), by Industry Vertical and by ... the global market is expected to grow from USD ... 2020, at a CAGR of 19.1%. , ...
(Date:3/9/2016)... March 9, 2016 This BCC Research report ... of the RNA Sequencing (RNA Seq) market for the ... instruments, tools and reagents, data analysis, and services. ... of the RNA-Sequencing market such as RNA-Sequencing tools and ... main factors affecting each segment and forecast their market ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... May 27, 2016 At present, the ... in this space know that volatility is what makes this ... on ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: SNTA ), ... (NASDAQ: LPTN ), and Heat Biologics Inc. (NASDAQ: ... to the technical alerts for these stocks at: ...
(Date:5/26/2016)... 26, 2016 Q BioMed Inc. (OTCQB: ... be a featured presenter at the 5th Annual Marcum MicroCap ... York City at the Grand Hyatt Hotel. ... BioMed Inc. CEO, is scheduled to begin at 11a.m ET ... business strategy, recent developments and outline milestones for the balance ...
(Date:5/26/2016)... ... May 26, 2016 , ... Kinder Scientific (KinderScientific.com), ... developments that position the Company for the future. Kinder Scientific announces restructured ... Kinghorn has been appointed Chairman of the Board, Curtis D. Kinghorn has been ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... delegation at BIO 2016 in San Francisco. Located at booth number 7301, representatives ... to answer questions and discuss the Thai biotechnology and life sciences sector. ...
Breaking Biology Technology: