Navigation Links
Neural stem progenitor cell transplantation’s potential to aid spinal cord injury tested

Tampa, Fla. (July. 11, 2011) A study published in the current issue of Cell Transplantation (20:5) investigating optimal routes for transplanting neural stem/progenitor cells (NS/PCs) in animal models of spinal cord injury (SCI) has demonstrated that intralesional (IL) injection conferred benefits over intravenous injection (IV) and intrathecal (IT) injection. The study, by a team of Keio University (Japan) researchers, is now freely available on-line at .

"Spinal cord injury usually results in severe, paralytic damage because the adult central nervous system has little potential for regeneration after injury," said corresponding author Dr. Masaya Nakamura of the Keio University School of Medicine's Department of Orthopedic Surgery. "With cell transplantation of neural stem/progenitor cells being a promising strategy, our study sought to determine the best method of application for optimal cell survival and subject safety."

For their study, the researchers used a new reporter gene, called "ffLuc," a novel fusion protein, for bioluminesence (BLI) imaging in order to track the transplanted cells via MRI from injection site to spinal cord lesion.

"MRI signals from dead cells cannot be distinguished from those of living cells," noted Dr. Nakamura. "To overcome this difficulty, we used a BLI system that tracked only living cells."

After inducing SCI in mouse models, the researchers compared the safety and efficacy results of IL, IT and IV injection methods for transplanting NS/PCs. IL grafting emerged as the best method since the IL-injected animals showed the best survival rates for grafted cells post-injection with no complications in the animals. IT injection showed low animal survival rates. IV injection resulted in no grafted cells migrating to the SCI lesion sites and many of the test animals died of a pulmonary embolism soon after injection.

"Taken together, our findings indicate that the best method for transplanting NS/PCs into the spinal cord injury site is by intralesional injection," summarized Dr. Nakamura.

"It is interesting that this study observed the greatest cell survival after neural stem cell transplantation directly into the lesion site after spinal cord injury" said Dr. Paul Sanberg, coeditor-in-chief of Cell Transplantation and executive director of the University of South Florida Center of Excellence for Aging and Brain Repair. "It will be of considerable importance to determine if this finding translates to increased recovery and also whether this translates to other disorders".


Contact: David Eve
Cell Transplantation Center of Excellence for Aging and Brain Repair

Related biology news :

1. Neural mechanisms of value bias in the human visual cortex
2. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
3. I feel your pain: Neural mechanisms of empathy
4. Neural mapping paints a haphazard picture of odor receptors
5. Ex vivo neural stem cell expansion
6. Low levels of vitamin B12 may increase risk for neural tube defects
7. Early brain activity sheds new light on the neural basis of reading
8. Creating ideal neural cells for clinical use
9. Identification of a key molecular pathway required for brain neural circuit formation
10. Neural stem cell differentiation factor discovered
11. Essential nutrient found in eggs may help lower risk of neural tube defects
Post Your Comments:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by Solution ... Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to 2022", ... 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at a ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... 09, 2017 , ... The award-winning American Farmer television series will feature 3 ... airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten ... to continue to feed a growing nation. At the same time, many of our ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses ... EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The ...
(Date:10/7/2017)... 2017  The 2017 Nobel Prize in Chemistry ... Dubochet, Joachim Frank and Richard ... microscopy (cryo-EM) have helped to broaden the ... community. The winners worked with systems manufactured by ... highly resolved, three-dimensional images of protein structures that ...
(Date:10/5/2017)... ... , ... LabRoots , the leading provider of educational and interactive virtual ... to cancer research with a month-long promotion supporting the advancement of breast cancer research ... use promo code PinkRibbon to get 10 percent off their purchase of every the ...
Breaking Biology Technology: