Navigation Links
Neural stem cells attack glioblastoma cells
Date:7/6/2010

In their latest research, scientists of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have demonstrated how the brain's own stem cells and precursor cells control the growth of glioblastomas. Of all brain tumors, glioblastomas are among the most common and most aggressive. Dr. Sridhar Reddy Chirasani, Professor Helmut Kettenmann and Dr. Rainer Glass (all MDC) and Dr. Michael Synowitz (Charit Universittsmedizin Berlin) have now shown in cell culture and mouse model experiments just how the body's own protective mechanism they identified in an earlier study, actually works (Brain, July 6, 2010, doi:10.1093/brain/awq128)*.

Glioblastomas are brain tumors that are most common in adults in their mid-fifties or early sixties. The causes for developing the disease are not yet known. Researchers assume that misdirected neural stem cells / precursor cells mutate into cancer cells and can form glioblastomas.

Several years ago the MDC and Charit researchers were able to show that normal stem cell/ precursor cells of the brain attack the tumor. Apparently, the tumor itself entices these stem cells to migrate over relatively long distances from the stem cell niches of the brain. Why this is so is unclear. Moreover, the researchers still do not know which substance attract the stem cells to the tumor. However, now they have discovered how the stem cells keep the tumor in check.

Stem cell protein induces signaling in glioblastoma cells

The scientists showed that the neural stem cells and neural precursor cells release a protein that belongs to the family of the BMP proteins (bone morphogenetic protein). This protein received its name for its ability to induce bone and cartilage tissue formation, the first characteristic that was known about it. However, BMP is active in the entire organism even in the brain.

Neural stem cells release BMP-7 in the brain in the vicinity of the glioblastoma cells. The protein influences a small population of cancer cells, the so-called tumor stem cells. The current consensus of researchers is that these tumor stem cells are the actual cause for the continuous tumor self-renewal in the brain. A small quantity of these cells is sufficient to form new tumors again even after surgery. BMP-7 induces signaling in the tumor stem cells, causing them to differentiate. This means that they are no longer tumor stem cells.

However, the activity of stem cells in the brain and thus of the body's own protective mechanism against glioblastomas diminishes with increasing age. This could explain why the tumors usually develop in older adults and not in children and young people.

Aim the destruction of tumor stem cells

The discovery of the tumor stem cells has led to new concepts in the therapy of glioblastomas. "Normal cancer cells" can be destroyed using conventional therapies (surgery, radiation, chemotherapy), which are seldom successful in tumor stem cells. The aim is therefore to develop therapy concepts to destroy these tumor stem cells. The findings from the mouse experiments of the researchers in Berlin could point to a new approach: reprogramming tumor stem cells into less harmful cells, which could then be destroyed with a therapy.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Searching for causes of neural disconnection in schizophrenia
2. Neural tissue contains imbalanced levels of proteins, U-M study finds
3. Induced neural stem cells: Not quite ready for prime time
4. Brain-controlled cursor doubles as a neural workout
5. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
6. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
7. Essential nutrient found in eggs may help lower risk of neural tube defects
8. Neural stem cell differentiation factor discovered
9. Identification of a key molecular pathway required for brain neural circuit formation
10. Early brain activity sheds new light on the neural basis of reading
11. Creating ideal neural cells for clinical use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a medical ... (IV) therapy, today announced receipt of its ISO 13485 Certification, the ... the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection ... "This is an important ...
(Date:7/20/2017)... 20, 2017 Delta (NYSE: DAL ) customers now ... aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at ... Delta,s biometric boarding pass experience ... is now integrated into the boarding process to allow eligible Delta SkyMiles ...
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... and OXFORD, England , Aug. 16, 2017 ... for biotech executive search and leadership development, and Virdis Group, ... have created an exclusive alliance that enables clients to leverage ... "For our clients here in the ... access to a diverse population of leadership talent throughout the ...
(Date:8/15/2017)... , ... August 15, 2017 , ... Kapstone Medical ... 10 years of successes helping medical technology companies and inventors develop and safeguard their ... renowned full-service national engineering firm with a portfolio of clients in the United States ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... of the largest Asian exhibitions for analytical and scientific instruments. This year’s symposium, ... be “New Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a ... downlights designed to stay tightly sealed and perform efficiently for years. The downlights ... location listings just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment ...
Breaking Biology Technology: