Navigation Links
Neural stem cells attack glioblastoma cells
Date:7/6/2010

In their latest research, scientists of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have demonstrated how the brain's own stem cells and precursor cells control the growth of glioblastomas. Of all brain tumors, glioblastomas are among the most common and most aggressive. Dr. Sridhar Reddy Chirasani, Professor Helmut Kettenmann and Dr. Rainer Glass (all MDC) and Dr. Michael Synowitz (Charit Universittsmedizin Berlin) have now shown in cell culture and mouse model experiments just how the body's own protective mechanism they identified in an earlier study, actually works (Brain, July 6, 2010, doi:10.1093/brain/awq128)*.

Glioblastomas are brain tumors that are most common in adults in their mid-fifties or early sixties. The causes for developing the disease are not yet known. Researchers assume that misdirected neural stem cells / precursor cells mutate into cancer cells and can form glioblastomas.

Several years ago the MDC and Charit researchers were able to show that normal stem cell/ precursor cells of the brain attack the tumor. Apparently, the tumor itself entices these stem cells to migrate over relatively long distances from the stem cell niches of the brain. Why this is so is unclear. Moreover, the researchers still do not know which substance attract the stem cells to the tumor. However, now they have discovered how the stem cells keep the tumor in check.

Stem cell protein induces signaling in glioblastoma cells

The scientists showed that the neural stem cells and neural precursor cells release a protein that belongs to the family of the BMP proteins (bone morphogenetic protein). This protein received its name for its ability to induce bone and cartilage tissue formation, the first characteristic that was known about it. However, BMP is active in the entire organism even in the brain.

Neural stem cells release BMP-7 in the brain in the vicinity of the glioblastoma
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Searching for causes of neural disconnection in schizophrenia
2. Neural tissue contains imbalanced levels of proteins, U-M study finds
3. Induced neural stem cells: Not quite ready for prime time
4. Brain-controlled cursor doubles as a neural workout
5. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
6. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
7. Essential nutrient found in eggs may help lower risk of neural tube defects
8. Neural stem cell differentiation factor discovered
9. Identification of a key molecular pathway required for brain neural circuit formation
10. Early brain activity sheds new light on the neural basis of reading
11. Creating ideal neural cells for clinical use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... VEGAS , Dec. 18, 2014   LaunchKey , ... for the post-password and Internet of Things era, today ... funding. The venture round was led by Metamorphic Ventures ... Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey has raised ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ...  report to their offering. One major ... With continuous advances in technology, it is important to ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... The Wildlife Conservation Society tracked a southern elephant seal ... York to Sydney and back again. , WCS tracked the ... animal nicknamed Jackson was tagged on the beach ... WCS conservationists fitted Jackson with a small satellite transmitter that ...
... Therapeutics, Inc. announced today promising clinical results ... umbilical cord blood) as part of double-umbilical cord ... malignancies who have undergone reduced-intensity conditioning therapy.  The ... American Society of Hematology (ASH) meeting, being held ...
... of Toronto have found an explanation for how the ... system to prevent infection, offering a potential clue to ... multiple sclerosis. "The findings shed light on the ... gut," said Prof. Jennifer Gommerman, an Associate Professor in ...
Cached Biology News:Elephant seal travels 18,000 miles 2Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference 2Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference 3Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference 4Intestine crucial to function of immune cells, research shows 2Intestine crucial to function of immune cells, research shows 3
(Date:1/22/2015)... Geneva, Switzerland (PRWEB) January 22, 2015 ... for characterized mammalian Research Cell Banks (RCBs) used for ... generated Research Cell Banks will include Next-Generation Sequencing ... cell’s genetic architecture de-risks biologic manufacturing by ensuring the ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. ... company focused on advanced wound care, announces that ... tissues, have been added to the Premier, Inc. ... the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product ...
(Date:12/24/2014)... DALLAS and NEW YORK , ... a biopharmaceutical company advancing patient care in critical areas, announced ... of common stock, and warrants to purchase up to an ... of $4.00 per share and $.01 per warrant.  The warrants ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... NEW BRUNSWICK, N.J., Jan. 4, 2012 The HealthCare Institute ... 2011 economic impact survey, which indicates that the life sciences ... economy. For the eighth consecutive year, the study was conducted ... slowing of economic activity, it is important to note that ...
... Calif., Jan. 4, 2012  Telik, Inc. (Nasdaq: TELK) today ... a corporate update at the 5th Annual OneMedForum Conference ... (3:00 p.m. Eastern time) in San Francisco.  A live ... on the Telik website, www.telik.com .  The archived ...
... InterMune, Inc. (NASDAQ: ITMN) today announced that it will ... of Esbriet® (pirfenidone) in Germany, as well as other ... open of the U.S. markets on Thursday, January 5, ... hosted by InterMune at 8:30 a.m. Eastern time that ...
Cached Biology Technology:HealthCare Institute of New Jersey Releases 2011 Biopharmaceutical and Medical Technology Economic Impact Data 2HealthCare Institute of New Jersey Releases 2011 Biopharmaceutical and Medical Technology Economic Impact Data 3InterMune to Report Unaudited Fourth Quarter Esbriet® Revenue and Business Update on January 5 2
... 400 Spun Columns, 10. *SizeSep 400 Spun ... 400 base pairs in length. - ... and pre-equilibrated in distilled water containing 0.15% Kathon ... ~ 400 base pairs. *Extremely useful ...
... The Light Diagnostics Universal Amplicon ... for use in the qualitative ... generated by in vitro ... use only; not to be ...
... GFX Purification Kit, 25 purifications. ... cDNA probesProvides efficient removal of unincorporated ... reactions with superior yields of labeled ... purification of cDNA labeled by either ...
... CyScribe GFX Purification Kit, 50 purifications. ... cDNA probesProvides efficient removal of unincorporated ... reactions with superior yields of labeled ... purification of cDNA labeled by either ...
Biology Products: