Navigation Links
Neural stem cell study reveals mechanism that may play role in cancer
Date:9/5/2007

current study, however, the team made the unexpected finding that gap junctions also play a crucial role in neuronal migration and that they function in a previously unrecognized way. Rather than functioning as a conduit through which molecular signals move, the two fused hemi-channels serve as a form of adhesion between the migrating neurons and the neural stem cell fibers.

Cell adhesion is a common mechanism, but its function had not been detected previously in gap junctions.

The discovery that gap junctions were involved in migration in any capacity was a surprise. Elias had been investigating whether the molecule functioned as a channel to regulate cell proliferation within embryonic neural stem cells of the developing rat brain, building on preliminary findings from the Kriegstein lab 15 years ago.

As part of one study, she had reduced the levels of gap junctions in the neural stem cells. To our surprise, she says, the newborn neurons that the stem cells produced piled up on one another and failed to migrate into the cortex.

To establish the role that gap junctions might play in neuronal migration, the team focused on the activity of the molecules subunits, known as connexons, in a series of studies in the developing rat brain. They honed in on two of these proteins Cx26 and Cx43 because they determined that they were expressed at high levels in migrating neurons and along radial fibers and that they were, in fact, highly localized in regions of the neurons that were in contact with radial fibers.

In a notable finding, says Elias, blocking the activity of either subunit significantly impaired migration to the neocortex, as seen in a striking cellular redistribution pattern of the neurons.

To determine the mechanism by which the gap junctions were functioning, the team selectively blocked three plausible mechanisms: the well-known channel function, a form of cellular signaling that relies on the intra
'/>"/>

Contact: Jennifer OBrien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Gene keeps neural cells on correct developmental path
2. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
3. Gambling monkeys give insight into neural machinery of risk
4. Brain size may depend upon how neural cells are cleaved
5. Defect in gene causes neuralgic amyotrophy
6. New insights into neural tube defects
7. Neural stem cell gene plays crucial role in eye development
8. Making a face: A new and earlier marker of neural crest development
9. Neural stem cells lend the brain a surprising capacity for self-repair
10. Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
11. Neural networking nanotubes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... According to a new ... Software, Services), by Applications (Surveillance (Airborne, Maritime, Land), ... (Military & Defense & Commercial) - Global Forecast ... is expected to grow from $7252.0 Million in ... Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/21/2015)... -- The Sync Project™ , a global collaboration ... announced a collaborative partnership with Berklee,s Institute for ... collaboration on original research, joint course development and an ... The Sync Project and BerkleeICE are exploring the launch ... 2015-2016 academic year.  The course will ...
(Date:5/20/2015)... 20, 2015 ... announced the addition of the  "5-year ... Recognition Market"  report to their offering.  ... service analyses trends in the iris ... commercial sectors, globally. Despite hardware pricing ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2
... release is also available in Chinese . ... one of humanity,s most ancient questions -- "what lives in ... an inventory of species distribution and diversity in key global ... data obtained during the decade-long Census to create a roll ...
... Board has elected ten new Fellows of the Society ... contributions in one or more of the following: research, ... recognized during Entomology 2010 -- ESA,s Annual Meeting -- ... California: Dr. Gary J. Blomquist received his B.S. ...
... COLD SPRING HARBOR, N.Y. (Mon., Aug. 2, 2010) -- ... fusing an engineered zinc finger DNA-binding domain to the DNA ... used to generate targeted genomic deletions of large segments of ... In the August issue of the journal Cold ...
Cached Biology News:Census of Marine Life publishes historic roll call of species in 25 key world areas 2Census of Marine Life publishes historic roll call of species in 25 key world areas 3Census of Marine Life publishes historic roll call of species in 25 key world areas 4Census of Marine Life publishes historic roll call of species in 25 key world areas 5Census of Marine Life publishes historic roll call of species in 25 key world areas 6Census of Marine Life publishes historic roll call of species in 25 key world areas 7Census of Marine Life publishes historic roll call of species in 25 key world areas 8Census of Marine Life publishes historic roll call of species in 25 key world areas 9Entomological Society of America names 2010 Fellows 2Entomological Society of America names 2010 Fellows 3Entomological Society of America names 2010 Fellows 4Entomological Society of America names 2010 Fellows 5Entomological Society of America names 2010 Fellows 6Entomological Society of America names 2010 Fellows 7Entomological Society of America names 2010 Fellows 8Entomological Society of America names 2010 Fellows 9Zinc finger nuclease, immunoprecipitation methods featured in Cold Spring Harbor Protocols 2
(Date:5/22/2015)... According to a new market ... Gel Electrophoresis, Agarose & Polyacrylamide Gel, Capillary Electrophoresis, Isoelectric ... & by End User - Global Forecast to 2020", ... reach around $1.98 Billion by 2020 with a CAGR ... Browse 226 ma rket data ...
(Date:5/22/2015)... Charm Sciences, Inc. is pleased ... (USDA), Grain Inspection, Packers and Stockyards Administration (GIPSA) ... Sciences to monitor aflatoxin in grains utilizing Charm’s ... FAST Aflatoxin Quantitative Test (solvent-based). , The Charm ... Water Extraction Technology to extract aflatoxin from the ...
(Date:5/22/2015)... Knowledgent , the data and analytics ... potential of big data analytics in the life sciences ... help life sciences and healthcare organizations understand the ways ... business insights. , The life sciences and healthcare industries ... patient profiling, compliance and regulatory requirements, and scientific research. ...
(Date:5/22/2015)... Baylor Research Institute (BRI) at ... Institute (TGen) in Phoenix, AZ , ... detection and treatments for patients with a broad range of ... to new clinical trials and access to technology to drive ... bench to bedside across Baylor Scott & White ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2New White Paper Explores the Potential of Big Data Analytics in Life Sciences and Healthcare 2Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4
... , LONDON , January 28 ... with CEO David,Brennan saying in a video interview on ... revenue line above company,expectations. , In the ... a 23%,rise in core operating profit and, significantly, a 12% dividend ...
... ... grew 67% in 2009 compared to 2008. The strong growth came from an increase ... of eLadder™ Safety, a comprehensive pharmacovigilance eLearning curriculum. , ... (PRWEB) January 28, 2010 -- BioSoteria, Inc., ...
... Chun Ning (Jeanie) Lau , an associate professor of ... Presidential Early Career Award for Scientists and Engineers ( PECASE ) ... Room of the White House. President Barack ... , the highest award bestowed by the U.S. Government upon scientists ...
Cached Biology Technology:AstraZeneca CEO Interviewed on Q4 and Full-Year Results 2009 2Drug Safety Firm BioSoteria Announces Exponential Growth in 2009 2Drug Safety Firm BioSoteria Announces Exponential Growth in 2009 3Drug Safety Firm BioSoteria Announces Exponential Growth in 2009 4Drug Safety Firm BioSoteria Announces Exponential Growth in 2009 5UC Riverside graphene specialist Jeanie Lau receives national honor at White House 2
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
... Source: Tritirachium album Description: Proteinase ... used in a wide range of applications purified ... bonds mainly following the carboxyl group of N-substituted ... and is classified as a serine protease. Proteinase ...
...
... RNase ONE Ribonuclease is a 27kDa ... the degradation of RNA to cyclic nucleotide ... the degradation of these intermediates to 3-NMPs ... the few known RNases that can cleave ...
Biology Products: