Navigation Links
Neural stem cell study reveals mechanism that may play role in cancer
Date:9/5/2007

In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brains fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration one that may also play an important role in other developmental processes and diseases, including cancer.

The finding, the cover story in a recent issue of Nature (Aug. 23, 2007), was led by Laura Elias, a neuroscience graduate student in the laboratory of senior author Arnold Kriegstein, MD, PhD, a professor of neurology and director of the UCSF Institute for Regeneration Medicine.

Elias is one of 16 UCSF CIRM Stem Cell Scholars up and coming young scientists funded by the California Institute for Regenerative Medicine, established by California voters in 2004 to allocate $3 billion over 10 years to support stem cell research.

Scientists have known that migration of neurons depends in part on motors within the cells that drive their movement along the neural stem cell fibers. They have also known that this migration depends on receptors on the neurons surface that sense signals in the environment that either repel or attract the cells, thus directing their path.

But little has been known about the molecules that mediate the interaction between the migrating neurons and the neural stem cell fiber itself. And relatively overlooked in this process has been the possible role of so-called gap junctions.

Gap junctions are pores, or channels, that form between cells. They are created when two hemi-channels, each in the membrane of a different cell, connect. The junctions are well known for their role in enabling cells to pass molecular signals to one another. In developing tissue, they are particularly active in supporting signaling that promotes cell proliferation, or cell division.

In the
'/>"/>

Contact: Jennifer OBrien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Gene keeps neural cells on correct developmental path
2. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
3. Gambling monkeys give insight into neural machinery of risk
4. Brain size may depend upon how neural cells are cleaved
5. Defect in gene causes neuralgic amyotrophy
6. New insights into neural tube defects
7. Neural stem cell gene plays crucial role in eye development
8. Making a face: A new and earlier marker of neural crest development
9. Neural stem cells lend the brain a surprising capacity for self-repair
10. Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
11. Neural networking nanotubes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
(Date:4/1/2015)... OXFORD, Conn. , Apr. 1, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... number of Wocket smart wallets is underway to early ... early access group includes usage at retail outlets including ... CVS Pharmacy. Users report Wocket was accepted at all ...
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... of the "Global Gesture Recognition Market in Automotive ... The analysts forecast the Global Gesture Recognition market in ... over the period 2013-2018. Gesture recognition is ... to different gestures of an individual. Gesture recognition technology ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... of Velociraptor rewrites evolutionary charts , The recent ... that dromaeosaurs, a group of carnivorous theropods that ... originated much earlier than previously thought. Rather than ... traced back to the Jurassic, possibly as far ...
... a pheromone emitted by older male elephants in musth influences ... surrounding elephants behave, a new study has found. , ... University of Auckland in New Zealand say the release of ... frontalin, depends on whether the male elephant is mature enough ...
... immune system to absorb and digest pathogenic intruders. Some ... multiply within the macrophages. Cell biologists at the University ... recently publication in the journal 'Traffic' (Vol. 6, No. ... pathogens escape the 'stomach' of the macrophages which might ...
Cached Biology News:Newly discovered birdlike dinosaur is oldest raptor ever found in South America 2Newly discovered birdlike dinosaur is oldest raptor ever found in South America 3Newly discovered birdlike dinosaur is oldest raptor ever found in South America 4Male elephants woo females with precise chemistry 2Male elephants woo females with precise chemistry 3Dangerous tricksters: Some bacterie use immune cells to reproduce 2Dangerous tricksters: Some bacterie use immune cells to reproduce 3
(Date:4/24/2015)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) has ... of bio-succinic acid used to produce a new ... that Bayer MaterialScience has begun commercializing.    ... eco, a series of bio-based waterborne polyurethane dispersions ... 65%.  IMPRANIL ® eco has been developed ...
(Date:4/24/2015)... April 24 , 2015 PAREXEL International ... services provider, today announced that Partnerships in Clinical Trials ... Management, the 2015 Clinical Innovator of the Year.  The ... team for the Company,s Perceptive MyTrials ® Data-Driven ... Thursday night during the 2015 Partnership Awards in ...
(Date:4/23/2015)... Dora, Florida (PRWEB) April 23, 2015 ... that it intends to conduct a groundbreaking pilot ... begin to be reversed in as little as ... the science of metabolic and nutritional medicine—will aggressively ... that cripple and destroy our aging brain. These ...
(Date:4/23/2015)... 2015  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) ... quarter 2015 results before the Nasdaq market opens on ... conference call and webcast to discuss its financial results ... 2015 at 8:00 a.m. Eastern Time (5:00 a.m. Pacific ... call by dialing 866-952-1906 (US) or 785-424-1825 (International) using ...
Breaking Biology Technology:Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2
... Source: Fiserv Imagesoft BROOKFIELD, Wis. Fiserv ... firm Fiserv, announced on Thursday that it has completed ... are geared specifically toward improving the security of image ... scanned image of an original check. , ,The new ...
... mission to Japan is building interest in possible Wisconsin ... abroad in a conference call Monday morning. , ,In ... Wisconsin representatives, Doyle has been speaking at biotechnology meetings ... much of today telling people about the value of ...
... of software. The first is that any mildly successful software ... an operating system. Thats a topic for another column. The ... piece of software that its designers never imagined. , ,EBays ... eBay bought Half.com intending to shut it down and move ...
Cached Biology Technology:Doyle builds bridges and hopes for deals in Japan 2Doyle builds bridges and hopes for deals in Japan 3Byron's laws of software 2Byron's laws of software 3