Navigation Links
Nervy research: Researchers take initial look at ion channels in a model system
Date:12/2/2009

Before one of your muscles can twitch, before the thought telling it to flex can race down your nerve, a tiny floodgate of sortscalled an ion channelmust open in the surface of each cell in these organs to let in the chemical signals that spur the cell to action. New research* at the National Institute of Standards and Technology (NIST) has allowed scientists to observe ion channels within the surface membrane for the first time, potentially offering insights for future drug development.

Because they function as gatekeepers for messages passing among nerve cells, ion channels are the target of a host of drugs that treat psychological and neurological issues. But because the proteins that form the channels are hard to observe, obtaining knowledge of their operation has proved difficult. Studies of the proteins have been limited to either the molecules in isolation or dried and crystallized to get an idea of their structures. Now, a multi-institutional team working at NIST's Center for Neutron Research (NCNR) has provided a glimpse of the proteins in their naturally occurring form and interacting with the surrounding cell membrane.

The findings, just reported in the journal Nature, improve our understanding of the moving portion of the ion channel that responds to voltage differences across the cell membrane, according to team leader Stephen White. While the work may not be of practical medical use for some time, he says, it is a useful step toward understanding how signals travelparticularly among neurons.

"All of the communications in the body are electrical," says White, a biophysicist at the University of California, Irvine. "The motion of life depends on ion channels responding to voltage differences, so that they open and close at just the right moment, controlling the use of energy. Without them, nothing would happen in the body."

By investigating this portion of the ion channel, called a voltage-sensing domain,
'/>"/>

Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Stem cell research: From molecular physiology to therapeutic applications
2. UC Davis bench-to-bedside research: Promising treatment in clinical trials
3. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
4. Harmonizing biobank research: An achievable world-wide goal
5. Toothsome research: Deducing the diet of a prehistoric hominid
6. K-State research: Freshwater pollution costs US at least $4.3 billion a year
7. Geisinger research: Antimalarial drug prevents diabetes in arthritis patients
8. Robotics research: Enhancing the lives of people with disabilities
9. Advances in the field of schizophrenia research: New genetic factors identified
10. New research: Fruit juice consumption not related to overweight in children
11. Paradigm shift in Alzheimerss research: new treatments
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nervy research: Researchers take initial look at ion channels in a model system
(Date:7/25/2014)... a molecular testing panel developed at UPMC greatly ... surgery for patients with thyroid nodules and cancer, ... Institute (UPCI), partner with UPMC CancerCenter., The test, ... other diagnostic testing agencies, improved the chances of ... percent, according to the study published this month ...
(Date:7/24/2014)... NEW YORK, NY (July 24, 2014) Scientists ... Research Institute are one step closer to creating ... from a patient,s own cells. , For ... stem (iPS) cells lines from skin samples of ... they developed an accelerated protocol to induce these ...
(Date:7/24/2014)... /PRNewswire-iReach/ -- The Geneva Healthcare Suite, an innovative technology ... emergency room wait times by an average of 92 ... according to a recent study published in the Academic ... the suite to access data from incoming patients, implanted ... "Using Geneva,s technology platform we have been able to ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... to develop and evaluate new tools to control the ... five year, 12 million project involving sixteen partners in ... Framework programme. Because malaria is transmitted by mosquitoes, ... Wide scale use of insecticides on bednets and ...
... has long been used as a crop fertilizer, but the ... in manure is ever present. The ratio of nitrogen to ... needs of most crops. Therefore, crops tend to be overloaded ... but the excess phosphorus from the process can damage the ...
... "The rapid translation of biologically-based laboratory discoveries into daily ... trip back from the clinic to the laboratory, to ... behavior. It is imperative for basic researchers to understand ... the knowledge and skills to integrate and use new ...
Cached Biology News:€12 million ($16.9 million) project to develop new tools for malaria control 2
(Date:7/25/2014)... Lawrence Livermore scientists Charles Westbrook and William ... " The World's Most Influential Scientific Minds ." , ... who were identified by analyzing citation data over the ... highest-impact work (2002-2012 and 2012-2013). The two were selected ... . , "This recognition is a great honor for ...
(Date:7/24/2014)... - July 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) ... long-term, randomized, active control Phase 3 study of Zerenex ... binder, for the treatment of hyperphosphatemia in patients with ... (PhosphatE binding and iRon delivery with FErric CiTrate in ... of the American Society of Nephrology ( JASN ...
(Date:7/24/2014)... Calif. , July 24, 2014  ECC West ... Denver, Colorado with University College Hospital (UCH) ... a development project to finance, design, construct, and operate ... Nigeria . Under the first of ... prepare scoping documents and funding applications. UCH Ibadan intends ...
(Date:7/24/2014)... and synthetic processes prefer to settle into equilibriuma ... is within the realm of non-equilibrium conditions where ... in energy and phases, such as temperature fluctuations, ... humans to regulate their body temperature, airplanes to ... activity. , But even though these conditions ...
Breaking Biology Technology:Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2New approach to form non-equilibrium structures 2
... SAN DIEGO, Oct. 4 Orexigen® Therapeutics, Inc. (Nasdaq: ... the treatment of obesity, today announced the schedule of ... taking place at the 28th Annual Scientific Meeting of ... the San Diego Convention Center, October 8-12, 2010.Sunday, October ...
... PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) ... special dividend payment of $0.50 per share to all stockholders ... record date. As previously announced, the conversion ... 15, 2012 was adjusted to 140.571 shares of common stock ...
... 1 Biotech posted its strongest monthly and quarterly performance ... September rally for equities in more than 70 years. The ... and 13 percent in the third quarter. The Dow Jones ... appreciation during what historically has been a bad month for ...
Cached Biology Technology:Orexigen® Therapeutics Announces Upcoming Data Presentations at the 28th Annual Scientific Meeting of The Obesity Society 2Biotech Posts Strong Third Quarter Performance as Capital Markets Go on a Tear 2Biotech Posts Strong Third Quarter Performance as Capital Markets Go on a Tear 3Biotech Posts Strong Third Quarter Performance as Capital Markets Go on a Tear 4
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
...
... suitable for use with RNA. ... with 0.1% diethylpyrocarbonate (DEPC) and ... DEPC.DNase/RNase-Free Distilled WaterDistilled Water is ... molecular biology applications. It is ...
IHC detection kit for BrdU in cells and tissues...
Biology Products: