Navigation Links
Nervous culprit found for Tassie devil facial tumor disease
Date:12/31/2009

Cells that protect nerves are the likely origin of the Devil Facial Tumour Disease (DFTD) that has been devastating Australia's Tasmanian devil population, an international team of scientists has discovered.

Devil Facial Tumour Disease (DFTD) is a transmissible cancer that affects only Tasmanian devils and was first reported in 1996. It is spread by biting and quickly kills the animals. The disease is characterised by large tumours, mostly on the face and mouth, which often spread to internal organs.

The research collaboration, led by Australian scientists, has found that DFTD originates from cells called Schwann cells, which protect peripheral nerve fibres.

The results have been published today in the international journal Science.

Through the discovery, the team has now identified a genetic marker that could be used to accurately diagnose the perplexing cancer, which has seen the devil listed as endangered and facing extinction.

Lead author Dr Elizabeth Murchison from the Australian National University said the Schwann cell discovery was significant as there are currently no specific diagnostic tests, treatments or vaccines available for the disease.

"We took biopsies from devil tumours and extracted genetic data from them," Dr Murchison said.

Dr Tony Papenfuss from Melbourne's Walter and Eliza Hall Institute then led the team that determined which genes were switched on in the tumours and identified their genetic signature.

"When we compared the signature of the tumours to other normal tissues we found the tumours were most like Schwann cells," Dr Papenfuss said.

Associate Professor Greg Woods from the University of Tasmania's Menzies Research Institute said the Schwann cell find was an important step in the process to further understand the disease.

"Devils develop tumours of all different types and the genetic markers we have identified are useful for telling apart the tumours that occur in DFTD from other kinds of tumours," Associate Professor Woods said.

The Schwann cell research was conducted as part of the Save the Tasmanian Devil Program's efforts to further explore DFTD. It was supported by the National Health and Medical Research Council and the University of Tasmania's Dr Eric Guiler Tasmanian Devil Research Grant.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-417-125-700
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Obesity and the central nervous system -- the state of the art
2. Rutgers scientists research reveals critical knowledge about the nervous system
3. Building the future -- 21st century nano tools to repair the nervous system
4. Queens study connects obesity with nervous system
5. Trainor Lab characterizes gene essential for prenatal development of nervous system
6. Researchers disprove 15-year-old theory about the nervous system
7. Development of an artificial simulator of the nervous system to do research into diseases
8. Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
9. Apple or pear shape is not main culprit to heart woes -- its liver fat
10. Key to out-of-control immune response in lung injury found
11. Natural chemical found in broccoli helps combat skin blistering disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nervous culprit found for Tassie devil facial tumor disease
(Date:3/14/2016)... , Allemagne, March 14, 2016 ... ) - --> - Renvoi : image ... --> --> ... biométriques, fournit de nouveaux lecteurs d,empreintes digitales pour ... de DERMALOG sera utilisé pour produire des cartes ...
(Date:3/10/2016)... 10, 2016   Unisys Corporation (NYSE: UIS ... (CBP) is testing its biometric identity solution at the ... to help identify certain non-U.S. citizens leaving the country. ... designed to help determine the efficiency and accuracy of using ... and will run until May 2016. --> ...
(Date:3/8/2016)... March 8, 2016   Valencell , the ... announced it has secured $11M in Series D ... a new venture fund being launched by UAE-based ... from existing investors TDF Ventures and WSJ Joshua ... continue its triple-digit growth and accelerate its pioneering ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... ... Doctors in Italy, Japan, the UK and the US have reached some surprising ... its link to malignant mesothelioma. Surviving Mesothelioma has just posted the details of their ... , The studies analyzed for the new report included more than 3,447 cancer patients. ...
(Date:5/26/2016)... NEW YORK , May 26, 2016 ... announced today that it will be a featured presenter at ... 2016 in New York City at ... Denis Corin , Q BioMed Inc. CEO, is scheduled ... presentation will cover the company,s business strategy, recent developments and ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a rising hotspot ... rated one of its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, ... unique and intimate team-building experience. , Each event kicks off with an olive oil ...
(Date:5/25/2016)... , ... May 25, 2016 , ... Scientists at the ... options being tried for mesothelioma may be hampering the research that could lead to ... Click here to read it now. , The team evaluated 98 ...
Breaking Biology Technology: