Navigation Links
Nervous culprit found for Tassie devil facial tumor disease
Date:12/31/2009

Cells that protect nerves are the likely origin of the Devil Facial Tumour Disease (DFTD) that has been devastating Australia's Tasmanian devil population, an international team of scientists has discovered.

Devil Facial Tumour Disease (DFTD) is a transmissible cancer that affects only Tasmanian devils and was first reported in 1996. It is spread by biting and quickly kills the animals. The disease is characterised by large tumours, mostly on the face and mouth, which often spread to internal organs.

The research collaboration, led by Australian scientists, has found that DFTD originates from cells called Schwann cells, which protect peripheral nerve fibres.

The results have been published today in the international journal Science.

Through the discovery, the team has now identified a genetic marker that could be used to accurately diagnose the perplexing cancer, which has seen the devil listed as endangered and facing extinction.

Lead author Dr Elizabeth Murchison from the Australian National University said the Schwann cell discovery was significant as there are currently no specific diagnostic tests, treatments or vaccines available for the disease.

"We took biopsies from devil tumours and extracted genetic data from them," Dr Murchison said.

Dr Tony Papenfuss from Melbourne's Walter and Eliza Hall Institute then led the team that determined which genes were switched on in the tumours and identified their genetic signature.

"When we compared the signature of the tumours to other normal tissues we found the tumours were most like Schwann cells," Dr Papenfuss said.

Associate Professor Greg Woods from the University of Tasmania's Menzies Research Institute said the Schwann cell find was an important step in the process to further understand the disease.

"Devils develop tumours of all different types and the genetic markers we have identified are useful for telling apart the tumours that occur in DFTD from other kinds of tumours," Associate Professor Woods said.

The Schwann cell research was conducted as part of the Save the Tasmanian Devil Program's efforts to further explore DFTD. It was supported by the National Health and Medical Research Council and the University of Tasmania's Dr Eric Guiler Tasmanian Devil Research Grant.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-417-125-700
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Obesity and the central nervous system -- the state of the art
2. Rutgers scientists research reveals critical knowledge about the nervous system
3. Building the future -- 21st century nano tools to repair the nervous system
4. Queens study connects obesity with nervous system
5. Trainor Lab characterizes gene essential for prenatal development of nervous system
6. Researchers disprove 15-year-old theory about the nervous system
7. Development of an artificial simulator of the nervous system to do research into diseases
8. Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
9. Apple or pear shape is not main culprit to heart woes -- its liver fat
10. Key to out-of-control immune response in lung injury found
11. Natural chemical found in broccoli helps combat skin blistering disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nervous culprit found for Tassie devil facial tumor disease
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:5/24/2016)... May 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology ... LCD display is the latest premium product recently added to the range of products ... ... ... 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of ... their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been ... Target to its list of well-respected retailers. This list includes such fine stores ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
Breaking Biology Technology: