Navigation Links
Neisseria meningitidis disseminates itself by sending out 'scouts'
Date:2/17/2011

the main protein which makes up the pili; namely, pilin", adds Guillaume Dumnil.

The researchers then discovered that the protein underwent various modifications over time. One of these, in particular, has proved more interesting than the others: The addition of a phosphoglycerol. This chemical group once grafted onto the pilin, gives the signal for dissemination.

Bacteria isolated from the colony depart as "scouts"

Following these initial results, the researchers discovered the presence of a gene which enabled the transfer of phosphoglycerol onto the pilin: the gene, pptB. This gene only becomes fully functional when the bacteria is in contact with the cells lining the wall of the throat. The frantic activity of the pptB gene causes the addition of phosphoglycerol to the pilin. This then loses one of its essential properties: its capacity to form aggregates. As a consequence, some of the bacteria detach themselves from the colony and, little by little, are disseminated. This strategy is used by the bacteria in order to colonize other areas of the throat and to cross the cells lining it. "This phenomena could almost be compared with the formation of metastases in cancer", says Guillaume Dumnil.

This is the first time that scientists have been able to accurately identify the chain of events which controls the bacteria in the bloodstream. It is a first step. "We now know how the Neisseria meningitidis passes from the throat into the blood. We hope to be able to demonstrate that an identical process is involved when the bacteria passes from the blood into the brain, instigating meningitis", concludes Guillaume Dumnil.

Furthermore, if the researchers were able to find molecules which can block this dissemination, they would have both a preventative tool (blocking colonization from the throat and passage into the bloodstream) and a therapeutic tool (limiting colonization from the blood vessels and transmission
'/>"/>

Contact: Sverine Ciancia
severine.ciancia@inserm.fr
33-144-236-086
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps scientists develop first examples of RNA that replicates itself indefinitely
2. Scientists discover how deadly fungus protects itself
3. Biodiversity itself begets a species cascade, researchers say
4. No longer a gray area: Our hair bleaches itself as we grow older
5. A window that washes itself?
6. Your body recycling itself -- captured on film
7. Wildflower armors itself against disease
8. Africa can feed itself in a generation: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014 Research and Markets ... the "iPhone 5S Fingerprint Sensor - Apple/AuthenTec ... to their offering. ... AuthenTec in July 2012, Apple introduced the fingerprint ... currently the only device of Apple incorporating such ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... "Micro Market Monitor: North America Perimeter Security Systems ... http://photos.prnewswire.com/prnh/20130307/600769 The North American ... CAGR of 3.6% from 2014 to 2019. Although the ... Canada is expected to grow ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, ... fine-scale differences in genetic ancestry of individuals from across ... Since immigrants first arrived more than four hundred years ... served as a meeting place for peoples from different ... ongoing mixing of peoples with African, European, and American ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... Researchers report that performing angioplasty (a treatment that involves ... a clogged artery to help widen it) on veins ... an effective way to treat the venous abnormalities found ... The findings were presented at the Society of Interventional ...
... the ocean,s fisheries, solutions can be found in a surprising ... on March 23 in the journal Fish and Fisheries ... seven centuries of human habitation in Hawaii and the Florida ... and evaluated the management strategies associated with periods of sustainability. ...
... and Lawrence Berkeley National Lab have discovered a new route ... electron) can move from one molecule to another a ... is a radically new way by which proton transfer may ... Dornsife College of Letters, Arts and Sciences. Krylov is a ...
Cached Biology News:Interventional radiology: Mitigating symptoms, improving quality of life of MS patients 2Interventional radiology: Mitigating symptoms, improving quality of life of MS patients 3Ancient civilizations reveal ways to manage fisheries for sustainability 2Ancient civilizations reveal ways to manage fisheries for sustainability 3Scientists discover new method of proton transfer 2
(Date:12/19/2014)... December 19, 2014 Bioject Medical ... and manufacturer of needle-free injection technology, today announced ... Immunomic Therapeutics, Inc. (“ITI”) for ITI to use ... its LAMP™ vaccine platform. , In the ... Worldwide license to the Biojector®-2000 that triggers based ...
(Date:12/19/2014)... 2014 Charm Sciences is pleased to ... Detection of Aflatoxin M1 in raw commingled milk is ... party validation. The peer reviewed report of the validation ... for Agricultural and Fisheries Research (ILVO-T&V) has been published ... B1, the most toxic aflatoxin and a known carcinogen, ...
(Date:12/19/2014)... 19, 2014 BioPlus Specialty Pharmacy ... announces the promotion of Nick Maroulis, Pharm.D. to the ... Services. , In this position, Dr. Maroulis will ... managing the directors of our multi-site pharmacies as the ... 1997 and during that time he has served in ...
(Date:12/19/2014)... 2014 Naurex Inc., a biopharmaceutical company leveraging ... of the central nervous system, today announced that ... will present at the 33 rd annual J.P. ... at 3:00 p.m. PST on Tuesday, January 13, 2015, ... Francisco, Calif. About Naurex ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... SEATTLE, Jan. 11 Cell Therapeutics, Inc.,(CTI) (Nasdaq ... per le Societa e la Borsa ("CONSOB") granted ... the procedures set,forth by Article 8 and Article ... offerings of CTI,s common stock representing more than ...
... FDA Warns Pharmacies Not to Compound Commonly-Prescribed Hormone Estriol, ... Not to Use the ... statement regarding,compounded estrogens -- which include estradiol and estriol --,progesterone, ... medical experts in the field of Women,s Hormones," remarks Cheryle,Hart, ...
... CITY, Calif., Jan. 11 Maxygen, Inc.,(Nasdaq: ... development of,improved protein drugs, today announced that it ... Healthcare Conference on Thursday,January 17, 2008 at 7:45 ... will present. A live webcast of the presentation ...
Cached Biology Technology:Cell Therapeutics, Inc. Announces Authorization to Publish Italian Listing Prospectus 2Cell Therapeutics, Inc. Announces Authorization to Publish Italian Listing Prospectus 3Bio-Identical Hormone Menopause Doctor Responds to Outrageous FDA News 2
... yellow solution. In PBS ... and other proprietary stabilizers; ... formulated to stabilize activity ... conjugates at high conjugate ...
... WinMelt software is used ... of any DNA sequence up ... in optimizing placement of primers ... detection by denaturing gradient gel ...
... GT cell and PowerPac basic power supply are ... acids in agarose gels. The Mini-Sub cell GT ... and electrodes, a 7 x 7 cm UV-transparent ... and two 1.5 mm fixed-height combs (8- and ...
... and PowerPac basic power supply are used for ... agarose gels. The mini format cell includes a ... leveling bubble. The PowerPac basic power supply, 100-120 ... 4-400 mA, and 75 W. Power cord and ...
Biology Products: