Navigation Links
Need for speed
Date:3/18/2012

Like any law-abiding train passenger, a molecule called oskar RNA carries a stamped ticket detailing its destination and form of transport, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. They show that for this molecule, moving in the right direction isn't enough: speed is of the essence. Their study, published online today in Nature Structural & Molecular Biology, also provides clues as to how a single molecule could receive tickets for different destinations, depending on what type of cell it is in.

For a fruit fly embryo to develop properly, oskar RNA produced by the mother has to enter the egg cell, or oocyte, as it matures, and be taken to one of its ends the posterior pole. Researchers in Anne Ephrussi's group at EMBL have now found that this movement is more complicated than it seemed. When oskar is processed for transport by a mechanism called splicing, two different tags SOLE and EJC are attached to it, next to each other, at a specific spot. Ephrussi and colleagues found that both tags have to be in place for oskar to reach the right destination. Together, they seem to form a ticket that marks oskar for transport to the posterior pole, differentiating it from the many other RNAs that enter the oocyte bound for different destinations.

When they genetically altered the SOLE tag, the scientists found that oskar didn't go to the oocyte's posterior pole, as it should. But surprisingly, it did still move, and seemingly in the right direction. The problem, the researchers realised, was that oskar is racing towards a moving target. As the oocyte grows, it becomes longer, in effect taking the posterior pole further and further away as oskar is carried towards it. With a defective SOLE tag, oskar seemed unable to move fast enough to overcome the oocyte's growth. So somehow this 'ticket' affects the speed of transport, too.

Ephrussi and colleagues are now investigating
'/>"/>

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Grass to gas: UGA researchers genome map speeds biofuel development
3. New high-tech wound care products speed healing of ulcers, burns, injuries and surgical wounds
4. NJIT high speed rail expert to address DC conference next week
5. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
6. UCF nanotechnology may speed up drug testing
7. Georgia Tech develops speedy software designed to improve drug development
8. Genome-scale network of rice genes to speed the development of biofuel crops
9. Super-sized muscle made twin-horned dinosaur a speedster
10. Speed limit on babies vision
11. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Need for speed
(Date:3/31/2015)... 31, 2015  Elephant Talk Communications Corp. (NYSE MKT: ... of Software Defined Network Architecture (ET Software DNA® 2.0) ... of approximately $20.4 million for the year ended December ... for the year ended December 31, 2013. ... had completed its multi-year transition away from its legacy ...
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... the "Global Gesture Recognition Market in Automotive Sector ... analysts forecast the Global Gesture Recognition market in Automotive ... the period 2013-2018. Gesture recognition is the ... different gestures of an individual. Gesture recognition technology can ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... U.S. Department of Homeland,Security (DHS) announced today ... international visitors arriving at New York,s John ... part of the department,s,upgrade from two- to ... travel by more accurately and efficiently,establishing and ...
... that guide one of the two groups of pathogenic ... defense against the world. The work, they said, ... bacteria, like E. coli and salmonella, that would destroy ... protective coating. "A long-term goal is to find ...
... gene is integral to both fungal invasion of corn and ... lead to ways to control the pathogen and the poison. ... found that it is vital to the process of the ... when the scientists disabled the gene. At certain levels, ...
Cached Biology News:DHS Begins Collecting 10 Fingerprints From International Visitors at New York's John F. Kennedy International Airport 2Ant guts could pave the way for better drugs 2Defining gene's role may lead to prevention of dangerous corn toxin 2Defining gene's role may lead to prevention of dangerous corn toxin 3
(Date:4/16/2015)... 2015  Scientists from Cleave Biosciences will be participating ... at the American Association for Cancer Research Annual Meeting ... Sunday, April 19, 2015 from 3:15pm to 5:15pm ET. ... will present new in vivo and mechanism of action ... p97, a critical enzyme that controls various aspects of ...
(Date:4/16/2015)... LAUSANNE , Switzerland ... Debiopharm International SA (Debiopharm), part of Debiopharm Group ™ ... prescription drugs that target unmet medical needs ... that preclinical data on the investigational compounds ... inhibitor) will be presented at the 2015 ...
(Date:4/16/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ... DCVax® personalized immune therapies for cancer, announced today ... Cancer Immunotherapy Index (LCINDX), a professional index recently ... field within the biotechnology space.  ... companies" in the immunotherapy space, including 6 big ...
(Date:4/16/2015)... 2015 CCI Global Channel Management, the ... planning management software for major tech and telecom vendors, ... survey of channel vendor programs in software, hardware, and ... How the top IT vendors in each segment ... coming year. , Assessment of the state ...
Breaking Biology Technology:Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 2Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 3NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3CCI’s Channel Program Study Reveals 40% of IT Vendor Channel Staff Lack Adequate Access to Program and Partner Data 2CCI’s Channel Program Study Reveals 40% of IT Vendor Channel Staff Lack Adequate Access to Program and Partner Data 3
... what could be a shot in the arm for ... enhancing and controlling the growth of T cells in ... one of the therapy,s drawbacks. The engineers altered ... in which researchers can build new functions into cells ...
... TRIANGLE PARK, N.C. , April 26 Talecris Biotherapeutics Holdings ... results on April 28, 2010 , after the stock market closes ... on April 29, 2010 . , ... Investors and analysts may participate via phone by ...
... Volcano Corporation (Nasdaq: VOLC ), a leading developer and manufacturer ... treatment of coronary and peripheral vascular disease, today announced that it will ... Monday, May 3 . , ... The company will hold a conference call to discuss its financial ...
Cached Biology Technology:New technique reinforces immune cells that seek and destroy cancer, says Stanford researcher 2New technique reinforces immune cells that seek and destroy cancer, says Stanford researcher 3Talecris Biotherapeutics to Report First Quarter 2010 Financial Results 2Volcano Corporation Schedules First Quarter Conference Call, Webcast 2
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
... 1 kit. Facilitates the simple, phenol-free extraction ... hard tissue requiring proteinase K digestion.Each kit ... from 50 preparations of up to 25 ... & Purification, Purification and Amplification of Genomic ...
Request Info...
Ultra-sensitive, non-radioactive measurement of COX-I and COX-II activity...
Biology Products: