Navigation Links
Need for speed
Date:3/18/2012

Like any law-abiding train passenger, a molecule called oskar RNA carries a stamped ticket detailing its destination and form of transport, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. They show that for this molecule, moving in the right direction isn't enough: speed is of the essence. Their study, published online today in Nature Structural & Molecular Biology, also provides clues as to how a single molecule could receive tickets for different destinations, depending on what type of cell it is in.

For a fruit fly embryo to develop properly, oskar RNA produced by the mother has to enter the egg cell, or oocyte, as it matures, and be taken to one of its ends the posterior pole. Researchers in Anne Ephrussi's group at EMBL have now found that this movement is more complicated than it seemed. When oskar is processed for transport by a mechanism called splicing, two different tags SOLE and EJC are attached to it, next to each other, at a specific spot. Ephrussi and colleagues found that both tags have to be in place for oskar to reach the right destination. Together, they seem to form a ticket that marks oskar for transport to the posterior pole, differentiating it from the many other RNAs that enter the oocyte bound for different destinations.

When they genetically altered the SOLE tag, the scientists found that oskar didn't go to the oocyte's posterior pole, as it should. But surprisingly, it did still move, and seemingly in the right direction. The problem, the researchers realised, was that oskar is racing towards a moving target. As the oocyte grows, it becomes longer, in effect taking the posterior pole further and further away as oskar is carried towards it. With a defective SOLE tag, oskar seemed unable to move fast enough to overcome the oocyte's growth. So somehow this 'ticket' affects the speed of transport, too.

Ephrussi and colleagues are now investigating
'/>"/>

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Grass to gas: UGA researchers genome map speeds biofuel development
3. New high-tech wound care products speed healing of ulcers, burns, injuries and surgical wounds
4. NJIT high speed rail expert to address DC conference next week
5. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
6. UCF nanotechnology may speed up drug testing
7. Georgia Tech develops speedy software designed to improve drug development
8. Genome-scale network of rice genes to speed the development of biofuel crops
9. Super-sized muscle made twin-horned dinosaur a speedster
10. Speed limit on babies vision
11. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Need for speed
(Date:7/24/2014)... animal species for food or commercial food sale, has ... the decline of many species of primates and other ... than half of the species being consumed are birds, ... not only the meat made available for sale but ... by hunters and brought to villages for consumption, we ...
(Date:7/24/2014)... where electric cars ply silent freeways, solar panels blanket ... the earth, from howling winds and from the blazing ... it is technically and economically feasible to convert California,s ... energy. Published in Energy , the plan shows ... supply in California that could create tens of thousands ...
(Date:7/24/2014)... of researchers has developed a new nanoscale agent for ... for assessing the function and properties of the GI ... and treatment of gut diseases. , Illnesses ... and inflammatory bowel disease all occur in the intestine ... with diseases such as diabetes and Parkinson,s. , ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4New imaging agent provides better picture of the gut 2
... The evolution of bird bills is related to climate according ... Brock University, Canada. By examining bill sizes of a ... found that birds with larger bills tend to be found ... smaller bills. The study led by Dr Matt Symonds ...
... , In what is believed to be the largest review of ... are more likely to clump faster than others, scientists at Johns ... which they say likely control that bodily function. "Our results ... produced from these genes, to develop tests that could help us ...
... The American Association for Cancer Research recognizes the first ... Act, which was signed into law by President Obama ... the Food and Drug Administration (FDA) to regulate the ... go into effect today include restrictions on youth access ...
Cached Biology News:Birds reduce their heating bills in cold climates 2Genetic septet in control of blood platelet clotting 2Genetic septet in control of blood platelet clotting 3AACR recognizes 1-year anniversary of tobacco law 2
(Date:7/24/2014)... MESA, Calif. , July 24, 2014  Now ... close to home. Rehealth Regenerative Therapies , located ... athletes and other physically active people a new health ... Regardless of age, countless patients suffer from ... sport activities, such as muscle tears, torn rotator cuff, ...
(Date:7/24/2014)... Quantum computers have yet to materialise. Yet, scientists ... making such computers faster. One such approach relies ... controlled by applying an electric field. A new ... coherently coupled quantum dots (TQDs) with electrical impulses ... for example, should TQDs be used as quantum ...
(Date:7/24/2014)... California (PRWEB) July 24, 2014 ... to advances in modeling lithium-ion battery storage capacity. ... benefit from a theoretical model created at ... University that predicts how carbon components will ... energy storage emphasizes the urgent need for higher-performance ...
(Date:7/24/2014)...  Neogen Corporation (Nasdaq: NEOG ) advised ... revenue from new rodenticide research are premature. In its ... July 22, 2014, Neogen,s CEO commented about several new ... "It was my intent Tuesday at our conference ... new type of rodenticide, but certainly not to give ...
Breaking Biology Technology:Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Getting More Life out of Lithium-ion Batteries 2Neogen comments on SenesTech 2
... 2010 Sequenom, Inc. (Nasdaq: SQNM ... describing results from the R&D "locked-assay" verification study ... for Molecular Medicine. (Logo:   ... entitled "Noninvasive Detection of Fetal Trisomy 21 by ...
... 2010 Dr. Russell L. Chapman, former President of ... the research and teaching of algal related science in ... Chairman of its Science Advisory Board including university outreach, ... one of the preeminent scholars in the field of ...
... Dec. 15, 2010 /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc. ("China-Biotics" or ... developer, manufacturer and distributor of probiotics products in China, ... Stockholders (the "Annual Meeting") will be held on Wednesday, ... Annual Meeting will be held at the Company,s executive ...
Cached Biology Technology:Sequenom Announces Publication Acceptance of Manuscript From Trisomy 21 R&D Verification Study 2Sequenom Announces Publication Acceptance of Manuscript From Trisomy 21 R&D Verification Study 3Dr. Russell L. Chapman Joins Aquatic Energy as the Chairman of its Science Advisory Board 2Dr. Russell L. Chapman Joins Aquatic Energy as the Chairman of its Science Advisory Board 3China-Biotics, Inc. to Hold 2010 Annual Meeting of Stockholders on March 9, 2011 2China-Biotics, Inc. to Hold 2010 Annual Meeting of Stockholders on March 9, 2011 3
... ESGRO Complete Derivation Kit is intended ... cells from delayed blastocysts in serum-free ... Clonal Grade ... Blastocyst Incubation Medium Trypsin Solution ...
streptavidin, Alexa Fluor® 750–allophycocyanin conjugate (Alexa Fluor® 750–allophycocyanin streptavidin) *1 mg/mL*...
Template and primers for preparation of internal control spots...
Biotin-OSu is used to label proteins, immunological agents, DNA and synthetic oligonucleotides. Biotin labeling is detected through enzymatically labeled avidin or streptavidin proteins that conforma...
Biology Products: