Navigation Links
Need for speed
Date:3/18/2012

Like any law-abiding train passenger, a molecule called oskar RNA carries a stamped ticket detailing its destination and form of transport, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. They show that for this molecule, moving in the right direction isn't enough: speed is of the essence. Their study, published online today in Nature Structural & Molecular Biology, also provides clues as to how a single molecule could receive tickets for different destinations, depending on what type of cell it is in.

For a fruit fly embryo to develop properly, oskar RNA produced by the mother has to enter the egg cell, or oocyte, as it matures, and be taken to one of its ends the posterior pole. Researchers in Anne Ephrussi's group at EMBL have now found that this movement is more complicated than it seemed. When oskar is processed for transport by a mechanism called splicing, two different tags SOLE and EJC are attached to it, next to each other, at a specific spot. Ephrussi and colleagues found that both tags have to be in place for oskar to reach the right destination. Together, they seem to form a ticket that marks oskar for transport to the posterior pole, differentiating it from the many other RNAs that enter the oocyte bound for different destinations.

When they genetically altered the SOLE tag, the scientists found that oskar didn't go to the oocyte's posterior pole, as it should. But surprisingly, it did still move, and seemingly in the right direction. The problem, the researchers realised, was that oskar is racing towards a moving target. As the oocyte grows, it becomes longer, in effect taking the posterior pole further and further away as oskar is carried towards it. With a defective SOLE tag, oskar seemed unable to move fast enough to overcome the oocyte's growth. So somehow this 'ticket' affects the speed of transport, too.

Ephrussi and colleagues are now investigating
'/>"/>

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Grass to gas: UGA researchers genome map speeds biofuel development
3. New high-tech wound care products speed healing of ulcers, burns, injuries and surgical wounds
4. NJIT high speed rail expert to address DC conference next week
5. Evolution at warp speed: Hatcheries change salmon genetics after a single generation
6. UCF nanotechnology may speed up drug testing
7. Georgia Tech develops speedy software designed to improve drug development
8. Genome-scale network of rice genes to speed the development of biofuel crops
9. Super-sized muscle made twin-horned dinosaur a speedster
10. Speed limit on babies vision
11. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Need for speed
(Date:6/19/2013)... June 19, 2013 AT&T * ... upcoming launch of the ultimate workhorse among ruggedized ... As one of the most ruggedized phones equipped ... Terrain embodies toughened versatility and business-ready features.  Its ... keep workforces moving forward, while also keeping up ...
(Date:6/19/2013)... Insulin is the most potent physiological anabolic agent ... and synthesis of lipids, protein and carbohydrates, and ... system. It also plays a major role in ... glucose is metabolized and removed from the blood ... precise molecular mechanisms by which insulin regulates glucose ...
(Date:6/19/2013)... 19, 2013  New York College of Health Professions ... Patent and Trademark Office for detecting biometric changes through ... guards have been injured, attacked or killed. ... the Intellectual Properties Agreements of New York College of ... of New York College says, ...
Breaking Biology News(10 mins):AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 2AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 3AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 4AT&T and NEC Introduce Ultra-Rugged Smartphone Designed for Hard Work, Real Life 5Breakthrough research of essential molecule reveals important targets in diabetes and obesity 2New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 2New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 3New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 4
... Aug. 21, 2011 Groundbreaking research encompassing Case Western ... Medical Center, has uncovered a natural defense mechanism that ... Clostridium difficile , or C. diff , an ... settings. The research has immediate implications for developing a ...
... presence of a fetching female rat, a certain region of ... romance. Now Stanford University researchers have discovered that in male ... just as strongly to the odor of cat urine. ... Rachmaninoff for some cross-species canoodling? "Well, we see activity ...
... with a higher pre-pregnancy body mass index (BMI) are fatter ... in September,s issue of the journal Pediatric Research ... the effect of a mother,s BMI on her child,s development ... lifelong metabolic health problems. The research team used magnetic ...
Cached Biology News:Newly discovered cell mechanism uses amplified nitric oxide to fight C. diff 2Newly discovered cell mechanism uses amplified nitric oxide to fight C. diff 3Parasite uses the power of sexual attraction to trick rats into becoming cat food 2Parasite uses the power of sexual attraction to trick rats into becoming cat food 3Mother's BMI linked to fatter babies 2
(Date:6/19/2013)... --  NineSigma , Inc., of Cleveland ... NineSights.com is now the innovation engine for ... community of innovators. From technology developers, to ... stands out for its large community of innovators in ... all vetted by NineSigma. The community is free to ...
(Date:6/19/2013)... BioConvergence team members Curtis Strother and ... BioLogistics Summit in San Francisco earlier this month. ... IQ and IQPC, addressed the increasingly complex logistical ... attributed to current trends of globalization, outsourcing, and ... is an increase in movement, which is often ...
(Date:6/19/2013)... San Diego, CA (PRWEB) June 19, 2013 ... quality pipettes, Pipette.com is now stocked with Simport’s Dropette® ... , all aimed at the customer doing basic biology, ... blood work, and serology). , For over 35 years, ... and disposable plastic labware - products like the Simport ...
(Date:6/18/2013)... Los Angeles, CA (PRWEB) June 18, 2013 (PRWEB) ... of construction’s #1 time and attendance system in ... transfer software that shares employee data and payroll ... , AccountLinx Plus automates ExakTime software ... applications. The software imports employee data from a ...
Breaking Biology Technology:NineSigma Evolves Global Open Innovation through Social Media Platform, NineSights 2NineSigma Evolves Global Open Innovation through Social Media Platform, NineSights 3BioConvergence® Presents at BioLogistics Summit on Risk Matrix for Biosamples during Shipment 2Leading Pipette Distributor Pipette.com Now Stocks Transfer Pipettes: Simport’s Dropette and Heathrow Scientific Disposable Plastic Transfer Pipettes 2ExakTime Introduces AccountLinx Plus 2
... Cincinnati has long been known for its world-record-breaking ... Cincinnati have discovered new uses by spinning carbon ... properties. , Breakthroughs Without Broken Threads ... proven to grow carbon nanotubes of world-record breaking ...
... Inc. (NASDAQ: ONTY ) (TSX: ONY) (the "Company") ... December 31, 2008. , Net income for the year ended ... and $0.36 per diluted share, compared with a net loss ... for the year ended December 31, 2007. The change from ...
... Companies Require Most Dramatic ChangesNEW YORK, March 9 ... rising risk, more than 40 percent of executives surveyed ... say that their companies need to institute significant changes ... according to the results of a new white paper ...
Cached Biology Technology:Spinning carbon nanotubes spawns new wireless applications 2Oncothyreon reports full year and fourth quarter 2008 financial results 2Oncothyreon reports full year and fourth quarter 2008 financial results 3Oncothyreon reports full year and fourth quarter 2008 financial results 4Oncothyreon reports full year and fourth quarter 2008 financial results 5Oncothyreon reports full year and fourth quarter 2008 financial results 6Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 2Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 3Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 4Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 5
... is a fully automated microplate luminescence ... widest possible range of applications based ... assays luciferase, -galactosidase, gene activities with ... Luminescent Immunoassays Cell-based assays ...
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... Double staining is a technique used to ... tissue.(1-6) PicTure™-Double Staining Kit is a Zymed ... two antigens simultaneously in the same human ... The antigens can be identified using two ...
... exciting product for cell-based kinetic assays and ... use of expensive HTS equipment, which lead ... assay development stage. The NOVOstar offers the ... well as any other assay suitable for ...
Biology Products: