Navigation Links
Nearly a century later, new findings support Warburg theory of cancer
Date:1/11/2009

CHESTNUT HILL, MA (January 12, 2009) German scientist Otto H. Warburg's theory on the origin of cancer earned him the Nobel Prize in 1931, but the biochemical basis for his theory remained elusive.

His theory that cancer starts from irreversible injury to cellular respiration eventually fell out of favor amid research pointing to genomic mutations as the cause of uncontrolled cell growth.

Seventy-eight years after Warburg received science's highest honor, researchers from Boston College and Washington University School of Medicine report new evidence in support of the original Warburg Theory of Cancer.

A descendant of German aristocrats, World War I cavalry officer and pioneering biochemist, Warburg first proposed in 1924 that the prime cause of cancer was injury to a cell caused by impairment to a cell's power plant or energy metabolism found in its mitochondria.

In contrast to healthy cells, which generate energy by the oxidative breakdown of a simple acid within the mitochondria, tumors and cancer cells generate energy through the non-oxidative breakdown of glucose, a process called glycolysis. Indeed, glycolysis is the biochemical hallmark of most, if not all, types of cancers. Because of this difference between healthy cells and cancer cells, Warburg argued, cancer should be interpreted as a type of mitochondrial disease.

In the years that followed, Warburg's theory inspired controversy and debate as researchers instead found that genetic mutations within cells caused malignant transformation and uncontrolled cell growth. Many researchers argued Warburg's findings really identified the effects, and not the causes, of cancer since no mitochondrial defects could be found that were consistently associated with malignant transformation in cancers.

Boston College biologists and colleagues at Washington University School of Medicine found new evidence to support Warburg's theory by examining mitocho
'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Restless legs syndrome affects nearly 2 percent of US/UK children
2. Yam bean a nearly forgotten crop
3. NIH awards nearly $23M to University of Chicago for translational research
4. Yam bean a nearly forgotten crop
5. UCR researchers awarded nearly $1.7M to develop improved cowpea varieties
6. Gaining too much weight during pregnancy nearly doubles risk of having a heavy baby
7. Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D
8. 21st-century pack mule: MITs exoskeleton lightens the load
9. St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels
10. Carnivores in recent study help Bergmanns rule reach the 21st century
11. Building the future -- 21st century nano tools to repair the nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nearly a century later, new findings support Warburg theory of cancer
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition ... Report" report to their offering. This report analyzes ... by the following Segments: Face Biometrics, and Voice Biometrics. The report ... , Japan , Europe , ... & Africa , and Latin America ...
(Date:3/23/2015)... -- SoundView Technology Group issues a new research update following ... smart wallet. SoundView was one of the selected user groups to ... Wocket in multiple scenarios and outlets. Soundview ... making both debit and credit card payments.  ... company meets their plans in 2015, it would push our ...
(Date:3/23/2015)... OXFORD, Conn. , Mar. 23, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, announces ... a new advertising campaign on CNBC television starting March 30 ... ads will commence airing in New York ... Executive Officer said: "We are excited about our new ad ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... a well known cell surface protein inhibited prostate cancer ... disease that did not respond to hormone therapy, according ... of Urology and UCLA,s Jonsson Comprehensive Cancer Center. ... up regulated or turned on in prostate cancer that ...
... PHILADELPHIA Molecular biologist Jonathan Brody, Ph.D., ... Goney, Ph.D., research assistant professor, and member of ... in the Department of Pathology, Anatomy and Cell ... University have been awarded a W.W. Smith Charitable ...
... blood "metabolomics" profile of smokers immediately after they ... in cell death, inflammation, and other forms of ... Cancer Center, part of Georgetown University Medical Center. ... the Ninth AACR Frontiers in Cancer Prevention Research ...
Cached Biology News:UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer 2UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer 3Jefferson researchers receive W.W. Smith Charitable Trust 2Jefferson researchers receive W.W. Smith Charitable Trust 3Studying the metabolome of smokers, Lombardi researchers find early signs of damage 2
(Date:4/30/2015)...  Roka Bioscience, Inc. (NASDAQ: ROKA ), a ... for the detection of foodborne pathogens, announced plans to ... 2015 on May 7, 2015 after the close of ... host a conference call at 4:30 p.m. Eastern Time ... financial results. During the conference call, material information concerning ...
(Date:4/30/2015)... 30, 2015 Cytokinetics, Incorporated (Nasdaq: CYTK) reported ... 2015 were $4.4 million, compared to $8.0 million during the ... first quarter was $8.9 million, or $0.23 per basic and ... the same period in 2014, of $8.7 million, or $0.27 ... 2015, cash, cash equivalents and investments totaled $117.5 million. ...
(Date:4/30/2015)... April 30, 2015 Nitto Avecia, ... announces its increased capacity and production capability to ... client variety and service fulfillment continues to drive ... improve process throughput capacities. , In ... installed downstream process equipment at its Milford, MA ...
(Date:4/30/2015)... 30, 2015 The following is an open letter ... China Cord Blood Corp (NYSE: CO ) from Jayhawk ... the independent directors of China Cord Blood Corp (" China ... $6.40 per share from Golden Meditech Holdings Co Ltd ("Golden ... would greatly benefit Golden Med and Mr. Kam, the Chairman ...
Breaking Biology Technology:Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5
... Edinburgh-based company 6S Ltd have launched CueMemories ... retrieve digital media by replicating the simple and effective functions of ... on episodic memory - the memory which stores personal experiences - ... we are used to applying to digital content. ...
... MichBio and KnowledgeWatch today announced the formation of a ... information gathering channel of value to Michigan biosciences companies. ... services to continually aggregate concentrations of bioscience news with ... and harvests information from a wide variety of sources ...
... 2011 BioStorage Technologies, a global provider of ... chain logistics for the bioscience industry, today announced ... include vapor-phase liquid nitrogen preservation at its state-of-the-art ... The expansion of vapor phase liquid nitrogen storage ...
Cached Biology Technology:Digital Media Storage and Retrieval That Replicates the Functions of the Human Brain 2Digital Media Storage and Retrieval That Replicates the Functions of the Human Brain 3MichBio and KnowledgeWatch Announce Strategic Alliance 2BioStorage Technologies Expands Liquid Nitrogen Storage in Germany-based Biorepository Facility 2
... m7G(5')ppp(5')G (Cap Analog) is used for ... in in vitro transcription reactions. Substitution of ... the GTP in an in vitro transcription ... cap structure into a large fraction of ...
... Incubator/Shaker HT is designed for ... Incubator/Shaker HT is ideal for ... and primer extension assays. iEMS ... a one-cabinet model, allowing the ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
...
Biology Products: