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Nearly 10 million euros ($13.6 million) in ERC grants for 6 Technische Universitaet Muenchen researchers
Date:1/24/2011

ptimization Methods for Computer Vision and Image Analysis," optimization methods will be developed for evaluating a variety of problems in computer vision and image analysis. A particular focus is on convex optimization methods and polynomial algorithms in order to identify the most versatile practical solutions with the shortest possible processing times. Prof. Cremers receives an ERC Starting Independent Researcher Grant.

How a Sick Heart Develops

Among congenital heart defects, the Tetralogy of Fallot is one of the most prevalent severe cardiac diseases. The heart is here malformed in four places so that it cannot function properly. As a result, the lungs receive decreased blood flow, and the body is not adequately supplied with oxygen. In severe forms only an operation during infancy can help. Although the disease has been characterized for over 100 years, scientists have only recently begun to understand the causes. Evidently, a specific group of cells malfunctions during embryonic heart development. With funding from the ERC Starting Grant, Prof. Karl-Ludwig Laugwitz will examine which components of the molecular regulation mechanism of these cardiac precursor cells are defective. The scientific team led by Prof. Laugwitz will gather connective tissue cells from the skin of Tetralogy of Fallot patients (who were operated on during childhood) and re-program these into pluripotent stem cells. These cells have characteristics similar to embryonic stem cells. From these, cardiac precursor cells and mature cells of the cardiovascular system can grow, enabling a study of the molecular mechanisms of heart development. The researchers hope to gain new insights in cardiovascular stem cell biology and use these for future regenerative therapies and tissue replacement in cardiology.

Prof. Karl-Ludwig Laugwitz was appointed to the Associate Professorship W2 of Cardiology at TUM's university hospital "Rechts der Isar" in 2005. He also wo
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Contact: Patrick Regan
regan@zv.tum.de
49-892-891-0515
Technische Universitaet Muenchen
Source:Eurekalert

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