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Neanderthal lineages excavated from modern human genomes
Date:1/29/2014

nce of selection. Last year, I would have bet that a Neanderthal/human hybrid would have been as fit as a fully modern human. This was mostly because we haven't been separated from them that long, on an evolutionary scale."

Nevertheless, the Neanderthals were also a probable source for at least a few genetic variations that were adaptive for their human descendants. Neanderthal DNA sequences are found in regions of the genome that have been linked to the regulation of skin pigmentation. The acquisition of these variants by mating with the Neanderthals may have proven to be a rapid way for humans to adapt to local conditions.

"We found evidence that Neanderthal skin genes made Europeans and East Asians more evolutionarily fit," Vernot said, "and that other Neanderthal genes were apparently incompatible with the rest of the modern human genome, and thus did not survive to present day human populations."

The researchers observed that certain chromosomes arms in humans are tellingly devoid of Neanderthal DNA sequences, perhaps due to mismatches between the two species along certain portions of their genetic materials. For example, they noticed a strong depletion of Neanderthal DNA in a region of human genomes that contains a gene for a factor thought to play an important role in human speech and language.

According to the scientists, the "fossil free" method of sequencing archaic genomes not only holds promise in revealing aspects of the evolution of now-extinct archaic humans and their characteristic population genetics, it also might provide insights into how interbreeding influenced current patterns of human diversity.

Additionally, such studies might also help researchers hone in on genetic changes not found in any other species, and learn if these changes helped endow early people with uniquely human attributes.


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Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

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