Navigation Links
Nature study reveals loss of essential blood cell gene leads to anemia
Date:11/13/2012

Athens, Ga. Scientists at the University of Georgia, Harvard Medical School and the University of Utah have discovered a new gene that regulates heme synthesis in red blood cell formation. Heme is the deep-red, iron-containing component of hemoglobin, the protein in red blood cells responsible for transporting oxygen in the blood.

The study was published online Nov. 7 and will be in the Nov. 22 print edition of the journal Nature. The findings promise to advance the biomedical community's understanding and treatment of human anemias and mitochondrial diseases, both known and unknown.

The geneknown as mitochondrial ATPase inhibitory factor-1 gene or Atpif1was uncovered from a chemical mutagenesis screen of zebrafish, an organism which shares many of the same genes that regulate blood development in humans.

"With zebrafish, we are able to accelerate natural disease processes and screen for many more mutations in blood than we could ever see in random circumstance of human patients," said study senior co-author Dr. Barry Paw, a hematologist and associate professor of medicine at Harvard Medical School.

"In our case, we were looking for mutants that were bloodless, presumably because whatever gene that was inactivated by the random mutation must be critical for blood development, if one of these embryos were bloodless."

That is what Paw and his team found when they stumbled upon the particular "bloodless" mutant zebrafish called pinotage. The loss of the Atpif1 gene was the cause of the fish's severe anemia.

The next step for the team was to determine if the anemia was a defect of iron metabolism or heme homeostasis. Collaborating with molecular biologist Jerry Kaplan at the University of Utah, the researchers discovered a possible link between Atpif1 and ferrochelatase, the terminal enzyme in heme synthesis.

UGA microbiologist Harry Dailey, a leading authority in the structure and function o
'/>"/>

Contact: Harry Dailey
hdailey@uga.edu
706-542-5922
University of Georgia
Source:Eurekalert

Page: 1 2

Related biology news :

1. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
2. Epigenetic signatures direct the repair potential of reprogrammed cells
3. Nature: Video reveals wave character of particles
4. 2012 ACMG Foundation/Signature Genomic Laboratories Travel Award winner announced
5. Stoneflies mapped across Ohio, with implications for water quality and nature conservation
6. Gene signature helps identify risk of relapse in lung cancer patients
7. Natures billion-year-old battery key to storing energy
8. Can natures beauty lift citizens from poverty?
9. Biosignatures distinguish between tuberculosis and sarcoidosis
10. Nature: Microscope looks into cells of living fish
11. Nature or nurture? It may depend on where you live
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... June 27, 2014  The American Academy of ... of Standards and Technology (NIST) and the Department ... research and forensic science expert members to the ... an element of the NIST,s Organization of Scientific ... the first appointments made to the new FSSB ...
(Date:7/10/2014)...  Unisys Corporation,s (NYSE: UIS ) subsidiary in ... announced that it has been selected by the Dutch Custodial ... Basic Provision Biometrics solution for penitentiaries across The ... with a solution based on its open standards-based LEIDA ... contract is up to seven years, with the new system ...
(Date:7/10/2014)... DUBLIN , July 3, 2014 ... the addition of the "Global Gesture Recognition ... Market - Forecasts to 2020" report to ... Global Gesture Recognition & Touch-Less Sensing ... been around for a while, but the companies ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... involving 74 researchers from 38 research institutes, scientists have ... The research appeared today in Nature Genetics . ... Institute,s Plant Sciences Department were the sole Israeli scientists ... contribution in mapping the genes and gene families responsible ...
... CORVALLIS, Ore. Researchers at Oregon State University ... laying the groundwork for genetic improvements to related fruits ... published today in the journal Nature Genetics . ... improved crops, particularly commercial strawberries," said OSU plant molecular ...
... researchers have determined that heat shock protein 90 (Hsp90) can ... ) by affecting a large portion of the yeast genome. ... has played a key role in shaping the evolutionary history ... RELEVANCE: Over the past several years, Whitehead Member Susan ...
Cached Biology News:Full woodland strawberry genome sequenced 2OSU helps decode strawberry genome in bid to improve fruit 2OSU helps decode strawberry genome in bid to improve fruit 3Heat shock protein drives yeast evolution 2Heat shock protein drives yeast evolution 3Heat shock protein drives yeast evolution 4
(Date:7/12/2014)... (PRWEB) July 12, 2014 ... various reagents used in the life science ... the life science reagents market towards remarkable ... manufacturers and providers of life science reagents. ... Report: http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . , The global ...
(Date:7/11/2014)... 2014 EPFL and the University of  ... of John P. Donoghue . The American neuroscientist ... . The new Wyss Center for ... Geneva , has named as its director ... P. Donoghue , founder of Brown University,s Institute for ...
(Date:7/10/2014)... Toronto, Canada (PRWEB) July 10, 2014 ... often present in very low abundance and are ... quite challenging and time-consuming. , Join presenters Dr. ... Laboratories, and Dr. John Anders, Head of Quality ... mass spectrometer-based approach that can speed detection and ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., ... the relaunch of his highly informative blog, now named Stem ... What are Stem Cells ?” Dr. Harman’s purpose for ... the basics of stem cell therapy so that pet owners ... treatment when considering regenerative medicine. , A veterinarian by trade, ...
Breaking Biology Technology:Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... of the Personal Genome Project and Matthew Trunnell of The Broad ... of Life Sciences ResearchSEATTLE, April 24 Isilon(R) Systems ... scale-out NAS, today announced a unique gathering of industry leaders from ... and Expo 2009 in Boston, Mass. Dr. George Church, ...
... April 24 United Therapeutics Corporation (Nasdaq: ... 2009 first quarter financial results before market open on ... teleconference on Friday, May 1, 2009, at 9:00 a.m. ... 877-718-5092, with international callers dialing 719-325-4795. A rebroadcast ...
... - Strong Product Offerings and ... Nucletron, a global leader in radiation oncology, ... of EUR112.4 million (US $165,million). EBITDA in 2008 ended ... million with a strong fourth quarter contributing significantly to,the ...
Cached Biology Technology:Isilon Hosts Industry Leaders Panel on the Future of Life Sciences and IT at Bio-IT World 2009 2Isilon Hosts Industry Leaders Panel on the Future of Life Sciences and IT at Bio-IT World 2009 3Nucletron Announces 2008 Results 2
... This kit allows for rapid, convenient, and ... simple bind/wash/elute process utilizes a spin column ... beads for concentration of proteins which were ... are strong ion exchangers, offering high binding ...
... angle system, 220-240 V, is used to resolve ... fragments by pulsed field gel electrophoresis (PFGE). The ... pump, 14 x 13 cm casting stand with ... thick comb, screened cap, disposable plug molds, 12 ...
... kit is designed to knockout or alter genes ... than one week. Red/ET recombination allows the exchange ... specific, and faithful manner. An FRT-flanked kanamycin resistance ... can be used to replace a gene on ...
... separation system using the asymmetric flow Field ... easily with Wyatts multi-angle light scattering (MALS) ... the Optilab DSP. The combined system provides ... the particles/molecules separated by the AFFF unit. ...
Biology Products: