Navigation Links
Nature study: Jefferson researchers unravel protein's elusive role in embryo and disease development
Date:3/2/2011

PHILADELPHIAReporting in Nature, scientists from Thomas Jefferson University have determined that a single protein called FADD controls multiple cell death pathways, a discovery that could lead to better, more targeted autoimmune disease and cancer drugs.

Twelve years ago, internationally-known immunologist Jianke Zhang, Ph.D., an associate professor in the Department of Microbiology and Immunology at Thomas Jefferson University, realized FADD, which stands for Fas-Associated protein with Death Domain, played an important role in embryonic development and the onset of some diseases, but he didn't know exactly why until now.

In the paper published online March 2, Dr. Zhang and researchers show this protein regulates not one but two types of cell deaths pivotal for embryo and disease development. It is now known that FADD causes apoptosis, the "healthy" cell death, while keeping necrosis, the "toxic" one, at bay.

Understanding this pathway is instrumental in developing drugs with selectivity and fewer side effects, said Dr. Zhang, a member of the Kimmel Cancer Center at Jefferson,

"This work has direct impact on our understanding of diseases: cancer, autoimmune disease, immune-deficiency disease," he said. "This is the one gene that regulates these two processes in cells, so now we can find targeted drugs to control the cell death process."

The research suggests that with the absence or variation in expression of this one protein, an embryo may not develop properly or a person may develop disease later in life.

"This breakthrough is a testimony to Dr. Zhang's research acumen and dogged determination to solve a longstanding mystery regarding the regulation of cell death pathways," said Tim Manser, Ph.D., professor and chair of the Department of Microbiology and Immunology at Jefferson. "It is gratifying to know that Thomas Jefferson University provides the research infrastructure that allows outstanding researchers like Dr. Zhang to make seminal discoveries, such as those reported in the Nature paper."

FADD's importance in embryogenesis and lymphocyte death response has been known, but the mechanism that underlies these functions in FADD has remained elusive.

Researchers found that mice that did not express FADD contained raised levels of RIP1, Receptor-Interacting Protein 1, an important protein that mediates necrosis and the apoptotic processes, and their embryonic development failed due to massive necrosis.

"When the FADD-mediated death process is deregulated, we will produce white bloods cells that will attack our own tissue, which is the cause of auto-immune diseases, such as arthritis and lupus," said Dr. Zhang. "And without the necessary cell deaths that are required for tumor surveillance, humans could develop cancer."

There are drugs currently under development today that activate TNF-a-related apoptosis-inducing ligand (TRAIL) death receptor signaling, which induces apoptosis through FADD in cancer cells specifically, but its mechanisms are not well understood and the treatment not perfected. There are also tumor cells that are resistant to TRAIL-induced apoptosis for unknown causes.

"The killing of these tumor cells is not efficient, and this paper actually figured out why," said Dr. Zhang. "We now know that the FADD protein, while required for apoptotic death, is inhibiting necrotic death in tumor cells."


'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related biology news :

1. Solving the riddle of natures perfect spring
2. Turning to nature for inspiration
3. When nature calls
4. Study identifies new genetic signatures of breast cancer drug resistance
5. Simulations aim to unlock natures process of biomineralization
6. Parascript SignatureXpert Wins Forensic Signature Verification Competition
7. CIC Announces Upcoming Webinar: Business Challenges & Technology Solutions in 2011: What Leading Insurance Carriers are Planning Now; eSignature Implications
8. Brain scans detect autisms signature
9. Nature honors outstanding faculty mentor
10. California pistachios: Dietitian and Mother Nature approved
11. CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... attendance control systems is proud to announce the introduction of fingerprint attendance control software, ... employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - http://photos.prnewswire.com/prnh/20160609/377487 ...
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... the launch of the Supplyframe Design Lab . Located in Pasadena, Calif., ... the future of how hardware projects are designed, built and brought to market. ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
(Date:6/23/2016)... -- On Wednesday, June 22, 2016, the NASDAQ ... Dow Jones Industrial Average edged 0.27% lower to finish at ... Stock-Callers.com has initiated coverage on the following equities: Infinity Pharmaceuticals ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... Learn more about these stocks by accessing their free trade ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
Breaking Biology Technology: