Navigation Links
Nature Methods study: Using light to control cell clustering
Date:2/12/2013

Troy, N.Y. A new study from engineers at Rensselaer Polytechnic Institute and the University of California, Berkeley, pairs light and genetics to give researchers a powerful new tool for manipulating cells. Results of the study, published in the journal Nature Methods, show how blue light can be used as a switch to prompt targeted proteins to accumulate into large clusters.

This process of clustering, or oligomerization, is commonly employed by nature to turn on or turn off specific signaling pathways used in cells' complex system of communications. The new study details how this process can be replicated with great precision, giving researchers new capabilities to control and influence the process of oligomerization and cell signaling.

Ravi Kane, the P.K. Lashmet Professor in the Howard P. Isermann Department of Chemical and Biological Engineering and faculty member of the Center for Biotechnology and Interdisciplinary Studies at Rensselaer, co-led the study with Professor David Schaffer of the Department of Chemical Engineering at the UC Berkeley. This study was made possible with support from the U.S. Department of Energy's Office of Basic Energy Science.

"Our study shows a new use for using energy, in this case light, as a tool to understand and control cellular function. In this study, we demonstrated a new method for turning specific cell signaling pathways on and off with spatial and temporal precision, and use this to help better understand the dynamics of the pathway. At the same time, our technique can be used to control certain cell functions," Kane and Schaffer said.

Looking ahead, Kane said, it is possible the new process may also one day be able to help optimize cellular function and produce products of interest to energy production, such as biofuels.

Results of the study, titled "Optogenetic protein clustering and signaling activation in mammalian cells," were published online last wee
'/>"/>

Contact: Michael mullaney
mullam@rpi.edu
518-276-6161
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
2. Epigenetic signatures direct the repair potential of reprogrammed cells
3. Nature: Video reveals wave character of particles
4. 2012 ACMG Foundation/Signature Genomic Laboratories Travel Award winner announced
5. Stoneflies mapped across Ohio, with implications for water quality and nature conservation
6. Gene signature helps identify risk of relapse in lung cancer patients
7. Natures billion-year-old battery key to storing energy
8. Can natures beauty lift citizens from poverty?
9. Biosignatures distinguish between tuberculosis and sarcoidosis
10. Nature: Microscope looks into cells of living fish
11. Nature or nurture? It may depend on where you live
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nature Methods study: Using light to control cell clustering
(Date:12/17/2014)... 2014 Research and Markets ( ... "Samsung Galaxy S5 - Home Button Synaptics ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... technology than the iPhone 5S, Samsung introduces for ... product. The Galaxy S5 home button ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader ... PerformTek biometric technology to industry leaders such as Intel, ... clinically validated, biometric wearable products. These products will be ... Las Vegas . ... accurate, flexible and robust – with the clinical data ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... , July 8, 2013 /PRNewswire-iReach/ -- Jade Holding Group, LLC ... plastic surgery and wellness centers, has just added a new ... Lipo procedure. In addition, Tickle Lipo has proven to be ... its special pricing for the procedure. (Photo: ...
... hairlike flagella that extend from their unicellular bodies. Some bacteria, ... living in the human gut, have multiple flagella that rotate ... turn somewhat acrobatically by unbundling their flagella, causing the cell ... But many microbes, including 90 percent of motile marine bacteria, ...
... , July 8, 2013  Fluke Biomedical, a global ... today the debut of its new ProSim 3 ... portability, the light and easy to carry ProSim 3 ... maintenance and repairs in the field. ...
Cached Biology News:Strax Rejuvenation Adds New Page to Website Devoted to Tickle Lipo Procedure 2Buckling up to turn 2Buckling up to turn 3Buckling up to turn 4Fluke Biomedical launches portable, feature-rich ProSim 3 and 2 Vital Signs Simulators 2
(Date:12/17/2014)... 17, 2014  United Therapeutics Corporation (NASDAQ: ... well as changes to Martine Rothblatt , Ph.D,s ... United Therapeutics announced the promotion of ... Officer and David Zaccardelli , Pharm.D. to Executive ... these promotions, Dr. Rothblatt,s title will change from Chairman ...
(Date:12/17/2014)... , Dec. 17, 2014 Tigercat Pharma, ... 2 study evaluating the investigational oral NK-1 receptor ... with severe, chronic itch who are unresponsive or ... including topical steroids and antihistamines. ... Visual Analog Scale (VAS) itch score from baseline, ...
(Date:12/15/2014)... 15, 2014 METTLER TOLEDO is ... tool, ParticleView V19 with PVM technology , ... particle vision and measurement tool continuously captures high-resolution ... ParticleView V19 then automatically prepares a report pairing ... size and concentration changes. This compelling blend of ...
(Date:12/15/2014)... Organovo Holdings, Inc. (NYSE MKT: ONVO) ... breakthrough 3D bioprinting technology,  today celebrated continued positive ... exVive3D TM Human Liver Tissue.  The product, ... release on November 18, has been recognized as ... for innovation. Most recently, on December ...
Breaking Biology Technology:United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3
... in denial, are shunning the subject. Smart ones are coming ... This is a revolution, and the entire model is about ... Explosion , ,The receptacles to receive the conventional TV ... handheld devices or the hundreds of gadgets and screens lying ...
... 2 of a two part interview. Read Part ... experience gives him rare insight into the world of entrepreneurship ... him that to succeed at anything, tenacity is essential. ... from the place Sargeant knew as a child. In June, ...
... Murder Mystery game Madison, Wis. - ... UW-Madison School of Education, hopes to bring a new ... which combine aspects of physical activity, traditional reading and ... the UW System and the Academic ADL Co-Lab ...
Cached Biology Technology:When TV surrenders to Web... 2When TV surrenders to Web... 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 2Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 4Augmented reality brings a new dimension to learning 2Augmented reality brings a new dimension to learning 3
... Imaging Systems offer an optional X-Ray ... researchers to conveniently capture and precisely ... and whole animals with molecular based ... molecular signals that are generated by ...
... vinyl curtains or parting strip ... support frame to form a ... meets cleanliness to Class 10/ISO ... units, lights, and ionizers are ...
... The first high-density serum biomarker chip ... serum proteins. An antibody chip containing 120 ... tool that enables biomarker discovery scientists to ... detection, benefits of therapy and the likelihood ...
... sensitive reagent for the detection of inorganic ... of recombinant E. coli phosphate-binding protein labeled ... to changes in its environment.How it worksBinding ... rapid and tight (Kd ~ 0.1 M), ...
Biology Products: