Navigation Links
Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections
Date:11/23/2008

ral infection of cells. Our data go a step further, providing compelling evidence that exposed PS itself is a promising anti-viral drug target that is involved in the pathogenesis of multiple viruses, suggesting the possibility of achieving broad-spectrum anti-viral effects using a single anti-PS agent. We look forward to further exploring the potential of bavituximab and other anti-PS antibodies against viruses for which there are few or no effective therapeutic options."

In the first study, 100% of mice infected with lethal murine CMV and treated with bavituximab recovered fully, while only 25% of control animals survived. In the second study, guinea pigs were infected with lethal Pichinde virus, which is a model virus for Lassa fever. Fifty percent of the bavituximab-treated group survived, while untreated animals all died. In this study, the anti-viral effect of bavituximab was further augmented by the addition of the standard of care drug ribavirin, with 63% of animals receiving the combination therapy surviving the potentially lethal infection.

"We are extremely pleased to see this research demonstrating the broad anti-viral potential of bavituximab and our anti-PS technology platform published in this highly regarded journal," said Steven W. King, president and CEO of Peregrine. "This new publication is the latest in a series of external validations of our anti-viral program. It follows a recently awarded federal government contract for assessment of anti-PS antibodies to treat viral hemorrhagic fevers, research on the role of PS in viral infections that was published in a leading science journal earlier this year, and a recent presentation on anti-PS antibodies at a global HIV conference."

Mr. King added, "Better prevention and treatment of viral diseases are urgently needed, and we are increasingly optimistic that bavituximab and our other anti-PS antibodies could be valuable contributors to the field."

PS i
'/>"/>

Contact: Barbara Lindheim
blindheim@biocompartners.com
212-918-4650
BioCom Partners
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Nature study demonstrates that bacterial clotting depends on clustering
2. Extreme nature helps scientists design nano materials
3. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
4. Cancer signatures uncovered
5. Nature publishes new evidence about the deep biosphere written by biogeoscientists
6. Dartmouth researchers discover gene signatures for scleroderma
7. Scattered nature of Wisconsins woodlands could complicate forests response to climate change
8. Giving nature a helping hand
9. A molecular switch turns on the flame in natures blowtorch
10. Male seahorses are natures Mr. Mom, Texas A&M researchers say
11. Nature paper describes technique for extracting hierarchical structure of networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... ) -- Scientists at the Houston Methodist Research Institute ... single cells using a pipette -- a common laboratory ... feat and preliminary test results in a recent issue ... . , "Studying single cells and their unique functions ... nanomedicine department. faculty member Lidong Qin, Ph.D., the project,s ...
(Date:8/19/2014)... and other science courses are increasingly being asked ... they have a new textbook to help them ... this month by Princeton Press and co-authored by ... Biological Synthesis (NIMBioS), teaches readers about basic mathematical ... explore and explain biological phenomena. , Suitable for ...
(Date:8/19/2014)... Anyone who has ever had a glass of fizzy ... the air. But in a finding with wide industrial ... push some particles down into the liquid as well. ... aerosol droplets, so we were surprised, and fascinated, to ... the same process injected tiny oil droplets into the ...
Breaking Biology News(10 mins):Moving single cells around -- accurately and cheaply 2New textbook introduces undergraduates to mathematics for the life sciences 2Bubbling down: Discovery suggests surprising uses for common bubbles 2Bubbling down: Discovery suggests surprising uses for common bubbles 3
... ( Lepilemur sahamalazensis ), other than the fact it roosts ... holes, and therefore risks falling victim to predators from both ... kept in any zoo. Prior to this research virtually ... that it has been classified as Critically Endangered, the top ...
... study published today in the journal Gondwana Research ... Antarctic and Indian tectonic plates, demonstrating how they formed ... from Royal Holloway University, The Australian National University and ... how the plates evolved and where they should be ...
... years, pilots flying into combat have jammed enemy radar to ... moths can do it, too. A new study co-authored ... pulses from their genitals to respond to bats producing the ... echolocation ability of their predators. Echolocation research may ...
Cached Biology News:Solitary lemurs avoid danger with a little help from the neighbors 2UF researcher shows hawkmoths use ultrasound to combat bats 2UF researcher shows hawkmoths use ultrasound to combat bats 3
(Date:8/20/2014)... (PRWEB) August 20, 2014 Not long ... E&L studies should be performed late in the development ... known. But current regulatory trends suggest that, like many ... the rise. In recent years, multiple drug sponsors have ... or address specific questions during phase I/II. It’s not ...
(Date:8/20/2014)... Aug. 20, 2014 /PRNewswire-iReach/ -- A case study ... between the school,s bioengineering department and the Intel® ... Intel® Software Academic Program, UCSD,s research focuses on ... human body.  Photo - ... the work of Dr. Todd P. Coleman ...
(Date:8/20/2014)... improve the health of your heart, researchers have discovered. ... a standard TENS machine like those designed to relieve ... the small raised flap at the front of the ... The stimulation changed the influence of the nervous system ... can drive failing hearts too hard. , Professor Jim ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient ... its myPROpad™ ePRO tablet with the addition of a ... most widely used and well-respected Patient Reported Outcome (PRO) ... is used during clinical trials and in other health ... used to demonstrate Health-Related Quality of Life outcomes (HRQoL) ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2'Tickling' your ear could be good for your heart 2EQ-5D™ Assessment Now Available for iPad 2
... Call Tomorrow (Tuesday) at 8:30 am EDT to ... Discuss the Clinical ... (NASDAQ: XTLB ; LSE: XTL; TASE: XTL) today announced,the initiation ... norepinephrine reuptake inhibitor (SNRI) - for the treatment of,diabetic neuropathic pain. ...
... CeloNova BioSciences, Inc.,("CeloNova"), a leading developer of ... fully color-coded line of embolic particles,Embozene(TM) Color-Advanced ... and Interventional Radiology Society of Europe (CIRSE) ... ) Embolic microspheres are used to ...
... 7 Monogram,Biosciences, Inc. (Nasdaq: MGRM ) announced ... to present a corporate overview at the,ThinkEquity Partners, G5: ... p.m. Eastern Time (10:30 a.m. Pacific Time) at the ... the live audio broadcast or the subsequent archived,recording, log ...
Cached Biology Technology:XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 2XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 3XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 4XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 5XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 6XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 7CeloNova BioSciences Announces World's First Line of Fully Color-Coded Embolic Particles at CIRSE: Embozene(TM) Color-Advanced Microspheres 2Monogram Biosciences to Present at the ThinkEquity Partners' Fifth Annual Growth Conference 2
... KitTM allows graphic manipulation of DNA sequences ... an award winning interface design that allows ... to providing sophisticated drawing capabilities for Mac ... "Best Plasmid Mapping Software" by the Biotechnology ...
... ISO 9001:2000 Certified USDA Research Registered OLAW ... Training AALAS Certified Technicians ... GLP Documentation Upon Request Focus ... for all your custom immunology service needs. ...
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
...
Biology Products: