Navigation Links
Natural pest control protein effective against hookworm: A billion could benefit
Date:7/23/2013

A benign crystal protein, produced naturally by bacteria and used as an organic pesticide, could be a safe, inexpensive treatment for parasitic worms in humans and provide effective relief to over a billion people around the world. Researchers from the University of California, San Diego, La Jolla, CA, report on this potentially promising solution in a study published ahead of print in the journal Applied and Environmental Microbiology.

Hookworms, and other intestinal parasites known as helminths infect more than 1 billion people in poverty-stricken, tropical nations, sucking the vitality from the body, and leaving hundreds of millions of children physically and mentally stunted. Current drugs are insufficiently effective, and resistance is rising, but little effort has been made to develop better drugs because the relevant populations do not represent a profitable market for drug companies.

"The challenge is that any cure must be very cheap, it must have the ability to be mass produced in tremendous quantities, safe, and able to withstand rough conditions, including lack of refrigeration, extreme heat, and remote locations," says Raffi Aroian, a researcher on the study.

In earlier research, Aroian and his collaborators described a protein, Cry5B, that can kill intestinal nematode parasitessuch as human hookwormsin infected test animals (hamsters). Cry5B belongs to a family of proteins that are generally accepted as safe for humans. These proteins are produced naturally in Bacillus thuringiensis (Bt), a bacterium which is applied to crops as a natural insecticide on some organic farms, and CryB proteins have been engineered into food crops such as corn and rice, to render them pest resistant.

As shown for the first time in this paper, Cry5B can also be expressed in a species of bacterium, Bacillus subtilis, which is closely related to Bacillus thuringiensis, and which is also related to bacteria which are present in some probiotics, says Aroian. In the current research researchers showed that a small dose of Cry5B, expressed in this bacterium can achieve a 93 percent elimination of hookworm parasites from infected hamsters. That, says Aroian, is substantially better than current drugs.

The scientific significance of the research, he says, is that "bacteria similar to those that are food gradewhich are cheap and can readily be mass produced--can be engineered to produce molecules that can cure parasitic diseases."


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Herpes infections: Natural killer cells activate hematopoiesis
2. Natural keystone molecules punch over their weight in ecosystems
3. 3D simulation shows how form of complex organs evolves by natural selection
4. University of Southern California scientists reveal natural process that blocks viruses
5. North Carolina Natural Heritage Program earns 2013 Award for Science and Technical Achievement
6. Methane emissions from natural gas local distribution focus of new study
7. New emissions standards would fuel shift from coal to natural gas
8. Men may have natural aversion to adultery with friends wives
9. The natural ecosystems in the Colombian Orinoco Basin are in danger
10. Walking in the footsteps of 19th and 20th century naturalists
11. Newly identified natural protein blocks HIV, other deadly viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... On Monday, the Department of Homeland Security (DHS) issued ... the Biometric Exit Program. The Request for Information (RFI), ... that CBP intends to add biometrics to confirm when ... , in order to deter visa overstays, to ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... STACS DNA ... Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a ... STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
(Date:6/23/2016)... CA (PRWEB) , ... June 23, 2016 , ... ... software, is exhibiting at the Pennsylvania Convention Center and will showcase its product’s ... conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials ...
Breaking Biology Technology: