Navigation Links
Natural pain relief from poisonous shrub
Date:7/11/2011

An extract of the poisonous shrub Jatropha curcas acts as a strong painkiller and may have a mode of action different from conventional analgesics, such as morphine and other pharmaceuticals. Details of tests are reported in the current issue of the International Journal of Biomedical Engineering and Technology.

Omeh Yusuf and Ezeja Maxwell of the Micheal Okpara University of Agriculture in Umudike, Nigeria, explain how J. curcas, also known as the "physic nut" is a perennial shrub that grows to 5 meters in height and belongs to the Euphobiaceace family. It is native to Central America but grows widely in other tropical and subtropical countries of Africa and Asia. The plant's fruit is combined with the stem bark of Cochlospermum planchonii in Nigerian medicine for treating diabetes mellitus and is also used traditionally as a painkiller. Other medicinal activities have been reported. The plant's seeds have been used for making soap, candles, detergents, lubricants and dyes and the seed oil is used in biodiesel.

The researchers extracted what they believed to be the physiologically active components of the leaves of J. curcas using methanol as solvent. They compared the effects of this extract at 100, 200 and 400 milligrams per kilogram of body mass, against 400 mg/kg of acetylsalicylic acid (aspirin) in standard laboratory animal tests for assessing the strength of painkillers.

They found that 100 mg/kg was an inadequate dose, however, 200 and 400 mg/kg doses produced analgesia comparable to aspirin, affirming the use of the plant for pain relief in traditional medicine. The team suspect that the extract may be acting through both peripheral and central pain mechanisms. Yusuf and Maxwell are now carrying out more work on isolating and characterizing the active ingredient in the extract and in determining the precise mode of action.

The search for novel analgesic drugs that have a different side-effect profile and lack the tolerance and addiction problems associated with morphine and other opiates is an important avenue of research in drug discovery science. Very few leads from traditional and herbal medicine are successful in generating a new product, but it should be remembered that aspirin and morphine themselves were both originally derived from natural sources.


'/>"/>

Contact: Omeh Yusuf
nduk41@yahoo.com
Inderscience Publishers
Source:Eurekalert

Related biology news :

1. Discovery of natural compounds that could slow blood vessel growth
2. Design of a compound that stabilizes the main natural suppressor of tumors
3. International Council for Science launches major research program on natural disasters
4. Natural and social sciences: ICSU embraces the need to work more closely together
5. Ecologists say metabolism accounts for why natural selection favors only some species
6. Natural Capital Project to develop conservation software
7. Honey adds health benefits, is natural preservative and sweetener in salad dressings
8. New research shows how gene function drives natural selection in important class of genetic elements
9. Apolipoprotein(a): A natural regulator of inflammation
10. Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
11. Particulate emission from natural gas burning home appliances
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... 23, 2016  The Prostate Cancer Foundation (PCF) is pleased to ... faster cures for prostate cancer. Members of the Class of 2016 were selected ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
Breaking Biology Technology: