Navigation Links
'Natural killer' cells keep immune system in balance
Date:10/1/2009

PROVIDENCE, R.I. [Brown University] Natural killer, or NK cells, are part of our innate immune system. A healthy body produces them to respond early during infection. They are activated and they kill cells infected with a given virus.

It turns out NK cells are even more important to the body than previously thought. Researchers from Brown University and McGill University now know that the cells also help keep T cells major players in cell-mediated immunity from over-responding. Such a balance helps T cells maintain their role in the body's adaptive immune response, rather than becoming too numerous and activated to cause harm.

The discovery, published in the September issue of the Journal of Experimental Medicine, could someday be used to help treat patients with compromised immune systems. Managing NK cell production might help stabilize the immune systems of people with HIV or keep patients from rejecting bone marrow or organ transplants.

The findings place an importance on understanding how to keep NK cells around, because they can be lost, said lead author Christine Biron, professor of medical science at Brown University.

"The work reveals two important aspects of NK cell biology, the first piece being understanding how to keep NK cells instead of losing them," said Biron, the Esther Elizabeth Brintzenhoff Professor in the Department of Molecular Biology, Cell Biology and Biochemistry. "The second is that if you can keep them around, they have an important regulatory function to limit adaptive immune response. If you don't have them during long challenges, your adaptive immune system response could go unregulated and lead to death."

Scientists have known that NK cells have antimicrobial effects. But the newer research focuses on factors that help keep NK cells around. Through studying mice, researchers determined that the ability to keep NK cells around depends on whether they have a particular kind
'/>"/>

Contact: Mark Hollmer
Mark_Hollmer@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Barrow researcher finds natural hydrogel helps heal spinal cord
2. UCR Turfgrass Field Day to focus on water conservation, disease management, & natural turf
3. Natural compounds, chemotherapeutic drugs may become partners in cancer therapy
4. Restoring a natural root signal helps to fight a major corn pest
5. Salt marshes: A natural and unnatural history
6. Scientists link immune systems natural killer cells to infant liver disease
7. Natural compound stops retinopathy
8. Natural-born divers and the molecular traces of evolution
9. Natural seed treatment could drastically cut pesticide use
10. Small molecules mimic natural gene regulators
11. Rabbits on the back foot -- but naturally theyre fighting back
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Natural killer' cells keep immune system in balance
(Date:8/27/2014)... getting effective doses of the HIV drug maraviroc, a ... studies, completed before the drug was licensed in 2007, ... is key to removing maraviroc from the body. The ... the protein including nearly half of African-Americans ... to those who lack the protein even when given ...
(Date:8/27/2014)... easier when it is related to ability that we ... a new melody more easily than learning how to ... Center for the Neural Basis of Cognition (CNBC)a joint ... Universityhave discovered a fundamental constraint in the brain that ... story in the Aug. 28, 2014, issue of ...
(Date:8/27/2014)... An invasive grass species frequently found in forests ... then feed on American toads, a new University of ... accidentally introduced to the U.S. in the early 1900s, ... has spread to more than a dozen states in ... along roads and in forests, it can survive in ...
Breaking Biology News(10 mins):Dosage of HIV drug may be ineffective for half of African-Americans 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3
... May 2, 2008 Wiley-Blackwell, the scientific, technical, medical, ... Sons, Inc. today announced the launch of Journal ... the Chartered Institution of Water and Environmental Management ... exploring the interactions between the diverse fields that ...
... new mechanism of infection for the most fatal bee ... which can kill entire colonies of bees. Every year, ... beekeepers all over the world. The only control measure ... of infection (pathogenic mechanism) was originally thought to be ...
... Moms they take fathering to a whole new level: ... to play the dominant parenting role, male pregnancy is a ... pipefish, seahorses and sea dragons. Texas A&M University evolutionary biology ... the effects of male pregnancy on sex roles and sexual ...
Cached Biology News:Wiley-Blackwell to launch Journal of Flood Risk Management 2Bees disease -- 1 step closer to finding a cure 2Male seahorses are nature's Mr. Mom, Texas A&M researchers say 2Male seahorses are nature's Mr. Mom, Texas A&M researchers say 3Male seahorses are nature's Mr. Mom, Texas A&M researchers say 4
(Date:8/27/2014)... (PRWEB) August 27, 2014 The Global ... in-depth study on the current state of the Trifluoroacetic ... provides a basic overview of the industry, including definitions, ... Chinese domestic market analysis are provided with a focus ... market. A comparison between the international and Chinese situation ...
(Date:8/27/2014)... Aug. 27, 2014 Research and ... "Global Lactic Acid  (Biodegradable Polymer, Food & Beverage, ... Forecasts to 2019" report to their offering. ... acid with an asymmetrical carbon atom. The main ... polymer, food and beverage, personal care product, and ...
(Date:8/27/2014)... MADISON, N.J. , Aug. 27, 2014 /PRNewswire/ ... significant potential to help physicians better identify early-stage ... progression and disability, according to a new study ... from Quest Diagnostics (NYSE: DGX ) ... of the 14-3-3eta protein outperformed conventional antibody-serum testing, ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 Guggenheim ... Guggenheim Partners, today announced the hiring of veteran equity ... senior equity analyst. Mr. Butler will focus on the ... our team a wealth of experience and a broad ... Ferrarie , Senior Managing Director and Head of Equities ...
Breaking Biology Technology:Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2
... SAN DIEGO, May 4 Bio-Matrix Scientific Group Inc. ... ) and Entest BioMedical Inc., its wholly owned subsidiary, ... Report to the U.S. Army Medical Research and Materiel ... therapeutic potential of adipose-derived stem cells (ASCs) harvested from ...
... Inc. ("Senesco" or the "Company") (NYSE Amex: SNT ... 31, 2009. Net loss for the three month period ended ... a net loss of $1,482,217, or $0.08 per share, for the ... net loss was primarily the result of a decrease in operating ...
... Inc. (OTC Bulletin Board: PLMO; Frankfort Borse: PLO) has ... of its Pulmo Science Inc. subsidiary and the originator ... at the 5th International Symposium on Peptide Receptors and ... June 26th to 29th. The paper, which is ...
Cached Biology Technology:Bio-Matrix Scientific Group & Entest BioMedical Submit Research Proposal to U.S. Army for Funding Adipose-Derived Stem Cells to Treat Traumatic Brain Injury 2Senesco Technologies Reports Third Quarter Fiscal 2009 Financial Results 2Senesco Technologies Reports Third Quarter Fiscal 2009 Financial Results 3Senesco Technologies Reports Third Quarter Fiscal 2009 Financial Results 4Senesco Technologies Reports Third Quarter Fiscal 2009 Financial Results 5Senesco Technologies Reports Third Quarter Fiscal 2009 Financial Results 6Senesco Technologies Reports Third Quarter Fiscal 2009 Financial Results 7Pulmo BioTech Inc. Announces Paper to be Presented at Symposium 2Pulmo BioTech Inc. Announces Paper to be Presented at Symposium 3
... Uncover the biological data hidden in your samples ... manufacturing allows you to create your own microarray ... at your own pace and receive delivery of ... eArray is a secure, online array creation application ...
... The high-performance triple quadrupole 1200L ... in today's cost-conscious environment - incorporating ... solutions for all liquid chromatography analytical ... (API) interface and the Transmission Quadrupole ...
C1-inhibitor (C1-INH)...
... ATP-Free using Mo Bio luciferase assay. Mo Bio ... that will allow you to certify your products ... enable you to deliver them to your customers ... detection limit is 3.5 x 10-12 /l, which ...
Biology Products: